Taub Institute: Genomics Core
AN NIA-FUNDED ALZHEIMER'S DISEASE RESEARCH CENTER

 

Columbia University
Medical Center
Neurological Institute

710 West 168th Street, 3rd floor
(212) 305-1818


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Clinical Trials

Clinical Trials Currently Enrolling Participants



Study of Tolcapone for Frontotemporal Dementia
This study will test if a medication called tolcapone (Tasmar®) can improve the symptoms of frontotemporal dementia (FTD). It will also test the utilitywith FTD.scan called fMRI for detecting changes that occur in the brain when a medication reduces symptoms and the effect of a common genetic variant on the symptoms of FTD. Men and women who have been diagnosed with FTD and are 40 to 85 years old may be eligible to participate.
For more information, please contact Masood Manoochehri at (212) 305-5710.

Citalopram for Agitation in Alzheimer's Disease (CitAD)
This is a research study, funded by the NIH, for people ages 50-99 who have Alzheimer's Disease and also have symptoms of agitation and/or aggression. The study includes medical evaluation by physicians who specialize in memory disorders and treatment with medication. Each eligible participant must have a family member or caregiver who can provide information during the research study.
Website information at: http://clinicaltrials.gov/ct2/show/NCT00898807.
For more information, please contact Corazon de la Pena at (212) 543-6132.

ENROLL
ENROLL-HD is a world-wide initiative to learn more information about Huntington's disease by evaluating individuals who are part of an HD family. Ultimately, information learned from this study may help in the development of future experimental drug studies aimed at slowing or postponing HD disease onset and progression. All individuals diagnosed with HD, and individuals age 18 and older from an HD family, regardless of genetic testing status are eligible to participate. 
For more information, please contact Paula Wasserman at (212) 305-4597 or email pl2032@columbia.edu.

CHAMPS
In this observational study, people with a diagnosis of Huntington's disease or at-risk for Huntington's disease are asked to perform three motor tasks: grasping an object, tapping on a computer keyboard and walking. The purpose of this study is to learn more about motor and functional changes in individuals with HD. The study visit will take approximately 1.5 hours, once every year for three years. 
For more information, please contact Dr. Ashwini Rao at (212) 305-1647.

Other Studies


Ameliorating age-related memory decline
In this study we are testing whether exercise or a derivative of chocolate ameliorates memory decline that occurs with aging. Individuals who are 55 years old and older are eligible.
For more information, please contact Scott Small (212) 305-1269.

Risk Factors for Frontotemporal Dementia
This study hopes to learn about genetic and non-genetic factors that may be involved in FTD. We will use information from clinical testing, neuropsychological testing, blood DNA, and MRI imaging to ascertain subtypes of FTD, and to find genes that might be associated with these subtypes. This study invites persons diagnosed with FTD or related disorders, as well as unaffected family members, to participate.
For more information, please contact Masood Manoochehri at (212) 305-5710.

Alzheimer's Disease Neuroimaging Initiative (ADNI-2)
This purpose of this study is to determine if brain imaging can help predict the onset and monitor the progression of Alzheimer's disease. The study will also use lumbar punctures and blood draws to determine if biomarkers can predict and monitor the disease. English and Spanish speaking people with memory complaints who are in good general health and between the ages of 55 and 90 may be eligible to participate.
For more information, please contact PhilipYeung: (212) 342-0522.

African American Genetics Study
The purpose of this study is to look at genetic risk factors for Alzheimer's disease among African Americans for people over the age of 60. The study involves an interview consisting of memory and thinking tests, questions about your heath and experiences, and a blood draw.
For more information, please contact Steven Philemond (212) 305-1893.

Late Onset Alzheimer Disease Study (LOAD)
The purpose of this study is to identify genes that may increase the risk for developing Alzheime's disease (AD). We are seeking families with at least two living siblings diagnosed with AD who are 60 years or older.
For more information, please contact Pedro Mena (212) 305-2309.

Dominantly Inherited Alzheimer Network (DIAN)
The main objective of this study is to learn about brain changes that may occur on people who carry a genetic mutation which causes early onset Alzheimer disease. These participants will receive an annual follow up before they present any symptoms and includes evaluations, mental status testing, MRI and PET scans, blood assays with genetic studies and assays of cerebrospinal fluids.
For more information, please contact Dolly Reyes-Dumeyer (212) 305-5953.

The study of Alzheimer Disease in Caribbean Hispanic Families
The purpose of this study is to identify genes that may increase the risk for developing Alzheime's disease (AD). We are seeking families and/or individuals who are 60 years or older, with or without memory problems.
For more information, please contact Angel Piriz (212) 305-2309.

Antidepressant Treatment Studies for Combined Depression and Memory Complaints
We are conducting medication treatment research studies for individuals age 55+ with both depression and mild memory and/or concentration difficulties. The studies offer neuropsychological testing for memory and psychiatric evaluation of mood. Treatment is provided for eligible individuals at no cost for at least 6 months.
For more information, please contact Kristina D’Antonio (212) 543-5956.

Genetic Linkage Study
We are seeking families of all nationalities and backgrounds for a study that seeks to identify genes that may increase the risk for developing Alzheimer's disease (AD). If your family has at least two living siblings diagnosed with AD who are 60 years old or older.
For more information, please contact Amanda Sena at (212) 305-5097.

Brain Donation Program: “Give the Gift of Knowledge”

Brain donation allows valuable information to be obtained regarding normal aging and diseases that affect memory. This information may be useful towards the goal of developing more effective treatment strategies. If you or a family member wish to learn more about this program.
For more information, please contact Arlene Lawton, RN at (212) 305-9086.

Lucy G. Moses Center for Memory and Behavioral Disorders
Changes in memory and thinking abilities can occur from a variety of conditions, not just Alzheimer’s disease.Taub Institute specialists offer a thorough multidisciplinary evaluation of memory and thinking difficulties. We are located at The Neurological Institute, Columbia University Medical Center, 710 West 168th Street, New York.
For appointments, please call (212) 305-6939.


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