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Innovation in Biological and Medical Sciences Distinguished Lecture

Louisa Gross Horwitz Prize Lecture
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Previous lectures:
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Louisa Gross Horwitz Prize Lectures

The Louisa Gross Horwitz Prize was established under the will of the late S. Gross Horwitz through a bequest to Columbia University, and is named to honor the donor's mother. Louisa Gross Horwitz was the daughter of Dr. Samuel David Gross (1805-1889), a prominent surgeon of Philadelphia, and author of the outstanding Systems of Surgery, who served as President of the American Medical Association.  Each year, since its inception in 1967, the Louisa Gross Horwitz Prize has been awarded by Columbia University for outstanding basic research in the fields of biology or biochemistry. The purpose of this award is to honor a scientific investigator, or group of investigators, whose contributions to knowledge in either of these fields are deemed worthy of special recognition.

The Louisa Gross Horwitz Prize website

2016 Louisa Gross Horwitz Press Release



Available Videos:
Speaker: S. Lawrence Zipursky, PhD
Lecture Date: November 12, 2015
Lecture Title: “Molecular Diversity, Cell Recognition, and the Assembly of Neural Circuits”

The 2016 Louisa Gross Horwitz Prize Lectures

Howard Cedar, MD, PhD

Howard Cedar, MD, PhD
Emeritus Professor, Molecular Biology
Edmond J. Safra Distinguished Professor
Faculty of Medicine
Hebrew University of Jerusalem

Lecture:
"The Secret of DNA Methylation"
Tuesday, November 22, 2016
10:00 a.m.
Davis Auditorium (Rm. 412), Schapiro Center (CEPSR)
530 West 120th Street

Howard Cedar was born in New York in 1943. He received his B.Sc. in mathematics from M.I.T. and then went on to do an MD and PhD in microbiology under the tutelage of Dr. James Schwartz at NYU, graduating in 1970. He carried out postdoctoral research with Dr. Eric Kandel at NYU and then with Dr. Gary Felsenfeld at the NIH in the framework of the Public Health Service. In 1973 he immigrated to Israel where he joined the faculty of the Hebrew University, becoming a full professor in 1981. Dr. Cedar was elected to EMBO in 1982, received the Israel Prize in 1999, and became a member of the Israel Academy of Sciences in 2003. He received the Wolf Prize in Medicine in 2008, the Emet Prize in Life Sciences in 2009, the Gairdner International Award in 2011, and the Rothschild Prize for 2012. Dr. Cedar studies the molecular biology of DNA methylation. His research has provided the foundations for understanding how epigenetic information plays a role in gene regulation, development, and disease.

Dr. Cedar and his wife, Zipora, have six children and 22 grandchildren.

Gary Felsenfeld, PhD

Gary Felsenfeld, PhD
NIH Distinguished Investigator

Lecture:
"Chromatin Structure, Epigenetic Mechanisms, and Long Range Interactions in the Nucleus"
Tuesday, November 22, 2016
3:30 p.m.
Clyde and Helen Wu Auditorium
Roy and Diana Vagelos Education Center
104 Haven Avenue

Gary Felsenfeld is a senior member of the Laboratory of Molecular Biology at the National Institute for Diabetes and Digestive and Kidney Diseases at the NIH and an NIH Distinguished Investigator. He studied theoretical physical chemistry at Cal Tech with Linus Pauling and during a postdoctoral year at Oxford with C.A. Coulson. He joined with Alexander Rich and David Davies in Rich's new laboratory at the NIH. In 1957 Drs. Felsenfeld, Davies, and Rich reported the first triple stranded nucleic acid structure. After three years in the Biophysics Department at the University of Pittsburgh, Dr. Felsenfeld returned to the NIH to help found the Laboratory of Molecular Biology, which brought together several young scientists with similar interests. He extended his previous work to investigations of nucleic acid interactions with small cations, then with synthetic polypeptides, and, finally, with histones. Ultimately that led him to studies of chromatin structure, which particularly addressed questions of the relationship between chromatin structure and gene expression, the role of histone modifications, and, most recently, the nature of chromatin domain boundaries. His current interests are in the structure and function of boundary elements, epigenetic mechanisms, and the large scale organization of chromatin within the nucleus, with a particular focus on biologically significant long range interactions.

Aharon Razin, PhD

Aharon Razin, PhD
Emeritus Professor, Biochemistry
Dr. Jacob Grunbaum Chair of Medical Science
Faculty of Medicine
Hebrew University of Jerusalem

Aharon Razin was born in 1935 in Tel Aviv, Israel. He received his B.Sc. from the Hebrew University in 1962 and then went on to do an M.Sc. and Ph.D. in the laboratory of Prof. Yaakov Mager on the subject of nucleotide metabolism. He did postdoctoral research in the laboratory of Dr. Robert Sinsheimer and since 1971 has been on the faculty of the Hebrew University where he is currently a full professor in biochemistry. Prof. Razin is an elected member of EMBO, received the Israel Prize for 2004, and became a member of the Israel Academy of Sciences in 2008. He received the Wolf Prize in Medicine in 2008, the Emet Prize in Life Sciences in 2009, and the Gairdner International Award in 2011.



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PAST LOUISA GROSS HORWITZ PRIZE WINNERS

2015 Lawrence Zipursky, PhD
Howard Hughes Medical Institute
University of California, Los Angeles
2014 James P. Allison, PhD
University of Texas
MD Anderson Cancer Center
2013 John Michael O'Keffe, PhD
University College London
Edvard I. Moser II, PhD
Norwegian University of Science and Technology
May-Britt Moser, PhD
Norwegian University of Science and Technology
2012 Joe Lutkenhaus, PhD
University of Kansas Medical School
Richard Losick, PhD
Harvard University
Lucy Shapiro, PhD
Stanford University School of Medicine
2011 Jeffery C. Hall, Ph.D.
Brandeis University
Michael Rosbash, Ph.D.
Brandeis University
Michael W. Young, Ph.D.
The Rockefeller University
2010 Thomas J. Kelly, M.D., Ph.D.
Memorial Sloan-Kettering Cancer Center
Bruce Stillman, Ph.D.
President, Cold Spring Harbor Laboratory
2009 Victor R. Ambrose, Ph.D.
University of Massachusetts Medical School
Gary Ruvkun, Ph.D. Harvard Medical School
2008 F. Ulrich Hartl, M.D., Max-Planck-Institute of Biochemistry Martinsried, Germany
Arthur Horwich, M.D., Yale University School of Medicine
2007 Joseph G. Gall, Carnegie Institution
Elizabeth H. Blackburn, University of California, San Francisco
Carol W. Greider, The Johns Hopkins University School of Medicine
2006 Roger D. Kornberg, Stanford School of Medicine
2005 Ada Yonath, Helen and Milton A. Kimmelman Center for Biomolecular Structure and Assembly of the Weizmann Institute of Science
2004 Tony Hunter, Salk Institute for Biological Studies
Anthony Pawson, University of Toronto
2003 Roderick MacKinnon, Rockefeller University
2002 James E. Rothman, Sloan-Kettering Institute
Randy W. Schekman, University of California, Berkeley
2001 Avram Hershko, Technion-Israel Institute of Technology, Israel
Alexander Varshavsky, California Institute of Technology, CA
2000 H. Robert Horvitz, Massachusetts Institute of Technology, Cambridge, MA
Stanley J. Korsmeyer, Harvard Medical School, Boston, MA
1999 Pierre Chambon, Institute Génétique et de Biologie Moleculaire et Cellulaire,
Université L. Pasteur, Illkirch-Strasbourg, France; Collége de France, Paris
Robert Roeder, Rockefeller University, New York, NY
Robert Tijan, Howard Hughes Medical Institute;University of California at Berkeley
1998 Arnold J. Levine, Rockefeller University, New York, NY
Bert Vogelstein, Johns Hopkins University, Baltimore, MD
1997 Stanley B. Prusiner, University of California, San Francisco
1996 Clay M. Armstrong, University of Pennsylvania, Philadelphia, PA
Bertil Hille, University of Washington, Seattle, WA
1995 Leland H. Hartwell, University of Washington, Seattle, WA
1994 Philippa Marrack, University of Colorado Health Sciences Center
John W. Kappler, University of Colorado Health Sciences Center
1993 Nicole Le Douarin, Institut d'Embryologie Cellulaire et Moléculaire, Nogent-sur-Marne, France
Donald Metcalf, The Walter and Eliza Hall Institute of Medicine, Victoria, Australia
1992 Christiane Nüsslein-Volhard, Max-Planck-Institut für Entwicklungbiologie, Tübingen, Germany
Edward B. Lewis, California Institute of Technology, Pasadena, CA
1991 Richard Ernst, Laboratorium für Physikalische Chemie, Zurich, Switzerland
Kurt Wuthrich, Swiss Federal Institute of Technology, Institut für Molekularbiologie und Biophysik, Zurich, Switzerland
1990 Stephen Harrison, Howard Hudges Medical Institute, Harvard University, Cambridge, MA
Michael G. Rossmann, Purdue University, West Lafayette, IN
Don C. Wiley, Howard Hughes Medical Center, Harvard Univ., Cambridge, MA
1989 Alfred G. Gilman, The University of Texas Southwestern Medical Ctr., Dallas, TX
Edwin G. Krebs, Howard Hughes Medical Institute Research Laboratories, University of Washington, Seattle, WA
1988 Thomas R. Cech, University of Colorado, Boulder, CO
Philip A. Sharp, Massachusetts Institute of Technology, Cambridge, MA
1987 Günter Blobel, The Rockefeller University, New York, NY
1986 Erwin Neher, Max-Planck Institute for Biophysical Chemistry, Gottingen, Germany
Bert Sakmann, Max-Planck Institute for Biophysical Chemistry, Gottingen, Germany
1985 Donald D. Brown, Carnegie Institution of Washington, Baltimore, MD
Mark Ptashne, Harvard University, Cambridge, MA
1984 Michael S. Brown, University of Texas Health Sciences Center, Dallas, TX
Joseph Goldstein, The University of Texas Southwestern Medical Center, Dallas, TX
1983 Stanley Cohen, Vanderbilt University School of Medicine, Nashville, TN
Vitkor Hamburger, Washington University, St. Louis, MO
Rita Levi-Montalcini, Instituto di Biologia Cellulare, Rome, Italy
1982 Barbara McClintock, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
Susumu Tonegawa, Massachusetts Institute of Technology, Cambridge, MA
1981 Aaron Klug, Medical Research Council, Laboratory of Molecular Biology, Cambridge, England
1980 Cesar Milstein, Medical Research Council, Laboratory of Molecular Biology, Cambridge, England
1979 Walter Gilbert, Harvard University, Cambridge, MA
Frederick Sanger, Medical Research Council of Molecular Biology, Cambridge, England
1978 David Hubel, Harvard University School of Medicine, Boston, MA
Vernon Mountcastle, Johns Hopkins Univ. School of Medicine, Baltimore, MD
Torsten Wiesel, Rockefeller University, New York, NY
1977 Michael Heidelberger, New York University School of Medicine, New York, NY
Elvin A. Kabat, Columbia University, New York, NY
Henry G. Kunkel, Columbia University, New York, NY
1976 Seymour Benzer, California Institute of Technology, Pasadena, CA
Charles Yanofsky, Stanford University, Stanford, CA
1975 K. Sune D. Bergstrom, Nobel Foundation, Stockholm, Sweden
Bengt Samuelsson, Karolinska Institute, Stockholm, Sweden
1974 Boris Ephrussi, Paris, France
1973 Renato Dulbecco, The Salk Institute, San Diego, CA
Harry Eagle, Albert Einstein College of Medicine
Theodore T. Puck, University of Colorado Medical Ctr., Denver, CO
1972 Stephen W. Kuffler
1971 Hugh E. Huxley, Medical Research Council, Laboratory of Molecular Biology,
Cambridge, England
1970 Albert Claude
George E. Palade, Yale University School of Medicine, New Haven, CT
Keith R. Porter, University of Maryland-Baltimore County, Catonsville, MD
1969 Max Delbrück, California Institute of Technology, Pasadena, CA
Salvador E. Luria, Massachusetts Institute of Techn., Cambridge, MA
1968 H. Gobind Khorana, Massachusetts Institute of Technology, Cambridge, MA
Marshall Warren Nirenberg, National Heart, Lung & Blood Institute, Bethesda, MD
1967 Luis F. Leloir, Instituto de Investigaciones Bioquimicas, Buenos Aires, Argentina


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