George Gallos, MD
Assistant Professor of Anesthesiology
My research interests includes mechanisms of smooth muscle relaxation, in particular the role GABAA channels may play in modulating airway smooth muscle and uterine smooth muscle relaxation.
Ruth Landau, MD
Professor in Anesthesiology at CUMC
Director of the Center for Precision Medicine, within the Department of Anesthesiology
As a clinician dedicated to help women better endure labor pain and childbirth, I am investigating the influence of genetics on pain and it’s relief. Applying precision medicine will allow us to predict one’s individual susceptibility to develop post-operative and chronic pain, pregnancy-related disorders such as preterm labor and preeclampsia and their outcomes.
I am convinced that Anesthesia and Pain Relief are complex bio-psycho-social phenomena that require in addition to genotyping, robust dynamic phenotyping. I strongly feel that tomorrow’s challenges are to identify clinically meaningful outcomes while performing translational research, with the intent to provide patients personalized, tailored, safe and effective care.
Laurence Ring, MD
Assistant Professor of Anesthesiology
Dr. Laurence Ring’s research focuses on acute lung injury that may be caused by invasive positive pressure ventilation. About one third of critically ill patients require invasive ventilatory support and about a quarter of those patients are thought to develop ventilator associated lung injury (VALI). In the time since the significance of this injury was recognized (ARDSNet Trial, 2000), strategies to treat or avoid the injury, namely the use of positive end expiratory pressure and a low tidal volume approach to ventilation, have become engrained in critical care and intraoperative medicine. However, despite these interventions, the disease still persists. In an attempt to gain a better understanding of the molecular biology underlying VALI, Dr. Ring’s current research centers on the development of a mouse model of ventilator associated lung injury. The mouse model will serve to identify novel pathways activated in VALI which may serve as therapeutic or prophylactic targets. We eventually hope to begin testing protocols and compounds in ventilated mice which will have the potential to reduce morbidity and mortality from VALI in humans.
Richard M. Smiley, MD, PhD
Professor of Clinical Anesthesiology (in Obstetrics and Gynecology)
Chief of Obstetric Anesthesia
Dr. Smiley's recent areas of research interest have been in the general area of pharmacogenetics. He has shown that a common genetic polymorphism (arginine 16) of the beta-2 adrenergic receptor has a significant protective effect on the incidence or outcome of preterm labor. Other recently published work has demonstrated that genetic variation of this receptor affects the hemodynamic response to spinal anesthesia and vasopressor use during cesarean section. In research on another receptor system, a common genetic variant of the mu-opioid receptor has been shown to significantly affect the analgesic response to spinal fentanyl in labor. Another investigation of altered drug and hormonal responses involves studying the response of the vascular system to vasoconstrictors and dilators during pregnancy compared to the non-pregnant state. This is being studied in humans using a mini-dose venous infusion technique and linear variable differential transformer ("LVDT") sensor. Dr. Smiley helped initiate and is participating in a multi-center study of the development of chronic or persistent pain after cesarean or vaginal delivery (the PAD study). Other clinical research projects and interest include studies of various drugs and strategies of use of spinal and epidural analgesia for the relief of labor, postoperative and postpartum pain.