The Pulmonary & Intensive Care Translational Outcomes Research (PICTOR) Group
The Pulmonary & Intensive Care Translational Outcomes Research (PICTOR) Group is a clinical and translational research group led by David J Lederer, MD, MS and Matthew R Baldwin, MD, MS. Our mission is to identify novel risk factors for interstitial lung disease and to improve the lives of lung transplant recipients, adults with advanced lung diseases, and survivors of critical illness. We also seek to train the next generation of clinical and translational investigators in pulmonary and critical care medicine.
The Group has 7 Cores:
- Pulmonary Core, directed by David J Lederer, MD, MS
- Critical Care Core, directed by Matthew R Baldwin, MD, MS
- Autoimmune Lung Disease Core, directed by Elana Bernstein, MD MS
- Research Coordination and Regulatory Core, directed by Tatiana Blue
- Training & Career Development Core, directed by David J Lederer, MD, MS
We have made novel discoveries about subspecialty care and its role in improving the outcomes of adults living with idiopathic pulmonary fibrosis, disparities in access to subspecialty pulmonary care and lung transplantation, and the impact that body composition and frailty have on older survivors of critical illness and on lung transplantation outcomes.
For more information, please contact Dr. Lederer [dl427@.columbia.edu] or Dr. Baldwin [mrb45@.columbia.edu].
Clinical and Research Infrastructure Integration
is integrated into active clinical programs at Columbia University Medical Center, including the New York Presbyterian/Pulmonary Fibrosis Foundation Interstitial Lung Disease Care Center, the NYP Lung Transplant Program, the Medical Intensive Care Unit at Columbia University, and the NYP Scleroderma Program (directed by Elana Bernstein, MD, MS).
works closely with existing research infrastructure and services at, including the CTSA-funded Irving Institute for Clinical and Translational Research, the Mailman School of Public Health’s Patient-Oriented Research Master’s degree program, the Office of Clinical Trials, and the Institutional Review Board.
What We Do
The PICTOR group conducts clinical and translational research in the following areas:
- Using population-based studies, such as the Multi-Ethnic Study of Atherosclerosis (MESA), we are examining the causes of lung injury, inflammation, and fibrosis in humans.
- We are examining the roles of obesity, body composition, and frailty in early lung transplant outcomes.
- We are performing early work examining obstructive sleep apnea and its contribution to subclinical alveolar epithelial cell injury and consequent fibrosis.
- We are examining disparities in access to subspecialty pulmonary care and lung transplantation in the United States.
- We are examining the unmet palliative care needs of ICU survivors as they relate to frailty status.
- We are examining racial and socioeconomic outcome disparities among older survivors of critical illness.
Who We Are
David J Lederer, MD, MS, Director, Pulmonary and Training/Career Development Cores |
Darryl Abrams, MD |
Jon Giles, MD, MPH |
Hilary Robbins, MD |
Michaela Restivo, MD |
|
Tatiana Blue, Director, Research Coordination and Regulatory Core |
Emma KT Benn, DrPH |
Matthew Lippel |
Debbie Rybak, MD |
Selected Publications
-
Diamond JM, Arcasoy S, McDonnough JA, Sonnett JR, Bacchetta M, D'Ovidio F, Cantu E 3rd, Bermudez CA, McBurnie A, Rushefski M, Kalman LH, Oyster M, D'Errico C, Suzuki Y, Giles JT, Ferrante A, Lippel M, Singh G, Lederer DJ, Christie JD. Adipose gene expression profile changes with lung allograft reperfusion. Am J Transplant. In press. [Abstract] [Full text]
-
Podolanczuk AJ, Oelsner EC, Barr RG, Hoffman EA, Armstrong HF, Austin JH, Basner RC, Bartels MN, Christie JD, Enright PL, Gochuico BR, Hinckley Stukovsky K, Kaufman JD, Hrudaya Nath P, Newell JD Jr, Palmer SM, Rabinowitz D, Raghu G, Sell JL, Sieren J, Sonavane SK, Tracy RP, Watts JR, WIlliams K, Kawut SM, Lederer DJ. High attenuation areas on chest computed tomography in community-dwelling adults: the MESA study. Eur Respir J. In press. [Abstract] [Full text]
-
Singer JP, Diamond JM, Gries CJ, McDounnough J, Blanc PD, Shah R, Dean MY, Hersh B, Wolters PJ, Tokman S, Arcasoy SM, Ramphal K, Greenland JR, Smith N, Heffernan P, Shah L, Shrestha P, Golden JA, Blumenthal NP, Huang D, Sonett J, Hays S, Oyster M, Katz PP, Robbins H, Brown M, Leard LE, Kukreja J, Bacchetta M, Bush E, D'Ovidio F, Rushefski M, Raza K, Christie JD, Lederer DJ. Frailty phenotypes, disability, and outcomes in adult candidates for lung transplantation. Am J Respir Crit Care Med 2015;192(11)1325-34. [Abstract] [Full text]
-
Singer JP, Peterson ER, Snyder ME, Katz PP, Golden JA, D'Ovidio F, Bacchetta M, Sonett JR, Kukreja J, Shah L, Robbins H, Van Horn K, Shah RJ, Diamond JM, Wickersham N, Sun L, Hays S, Arcasoy SM, Palmer SM, Ware LB, Christie JD, Lederer DJ. Body Composition and Mortality after Adult Lung Transplantation in the United States. Am J Respir Crit Care Med 2014;190(9):1012-21. [Abstract] [Full text]
-
Baldwin MR, Wunsch H, Reyfman PA, Narain WR, Blinderman CD, Schluger NW, Reid MC, Maurer MS, Goldstein N, Lederer DJ, Bach P. High burden of palliative needs among older ICU survivors transferred to post-acute care facilities: A single center study. Ann Am Thorac Soc. 2013. Oct;10(5): 458-65. PMID: 23987743; PMCID: 3960912. [Abstract] [Full text]
-
Lederer DJ, Kawut S, Wikersham N, Winterbottom C, Bhorade S, Palmer S, Lee J, Diamond J, Wille K, Weinacker A, Lama V, Crespo M, Orens J, Sonett J, Arcasoy S, Ware L, Christie J. Obesity and primary graft dysfunction after lung transplantation: the LTOG Obesity Study. Am J Respir Crit Care Med 2011;184:1055-61. [Abstract] [Full text]
Funding
-
R01 HL114626: Obesity, Inflammation, and Lung Injury after Lung Transplantation (PI: Lederer/Christie)
-
R01 HL087115: Clinical Risk Factors for Primary Graft Dysfunction (PI: Christie; site PI: Lederer)
-
R01 HL114468: Foxp3+ Treg Cells & Primary Graft Dysfunction in Clinical Lung Tx Recipients (PI: Hancock; site PI: Lederer)
-
U54 HL127672: Rare Lung Disease Consortium: Molecular Pathway-Driven Diagnostics & Therapeutics for Rare Lung Diseases, Hermansky-Pudlak Syndrome Project (overall PI: Trapnell; subproject PI: Young; site PI: Lederer)
-
American Federation for Aging Research/NIA Medical Student Training in Aging Research (MSTAR) Program at Weill Cornell Medical College (PI: Reid; Mentor: Baldwin; Recipient: Pollack)
-
Columbia Physicians & Surgeons Dean’s Research Fellowship (Mentor: Baldwin; Recipient: Pollack)
Donate
Columbia University Medical Center
Division of Pulmonary, Allergy, and Critical Medicine
622 W 168th Street, PH 9-215
New York, NY 10032