Academic Appointments
- Russell Berrie Foundation Professor of Diabetes (in Medicine)
Dr. Domenico Accili is Professor of Medicine at Columbia University and Director of the Columbia University Diabetes and Endocrinology Research Center in New York City. A graduate of the University of Rome, his training in Internal Medicine was served at the University Hospital Gemelli, also in Rome. Following a Fogarty Fellowship in the Diabetes Branch of the National Institute of Diabetes and Digestive Kidney Diseases, he became Chief of the Section on Genetics and Hormone action of the National Institute of Child Health at the National Institutes of Health in Bethesda, Maryland. Since 1999, he has served on the faculty at Columbia University College of Physicians & Surgeons and as an Attending Physician at Columbia-Presbyterian Hospital.&
Dr. Accili's research has delved into the pathogenesis of diabetes, the integrated physiology of insulin action and mechanisms of pancreatic beta dysfunction. He is best known for the identification of a family of DNA-binding proteins that collectively regulate diverse pathophysiological processes, including liver glucose and lipid production, food intake, insulin production and adipogenesis. He has received numerous awards, including the 2003 Lilly Award for Outstanding Scientific Achievement by the American Diabetes Association. His work has been published in leading medical research journals. He has served on several editorial boards, including the Journal of Clinical Investigation and Diabetes. He is a member of numerous advisory panels for academia, government and industry. He is an elected member of the Association of American Physicians and the American Society for Clinical Investigation. His work is supported by the National Institutes of Health, the American Diabetes Association, the Russ Berrie Foundation, and the Brehm Coalition.
Departments and Divisions
- Department of Medicine
Division of Endocrinology
Education and Training
- University of Cattolica, Italy
- Fellowship: National Institutes of Health
Lab Locations
CUMC/Russ Berrie Medical Science Pavilion
1150 St. Nicholas Avenue
New York, NY 10032
Committees / Societies / Memberships
Advisory Board, Diabetes Gene Discovery Group, Genome Canada
Honors and Awards
- Association of American Physicians
- American Society for Clinical Investigation
- Member, Metabolism Study Section
- Advisory Board, NIDDK Beta Cell Biology Consortium
- Advisory Board, Congressional Special Statutory Funding Program for Type 1 Diabetes Research
- Molecular and Cellular Endocrinology Study Section
- Chair, Beta Cell Group, Diabetes Research Strategic Plan, NIDDK
- Member, NIDDK Council
- MERIT Award, NIDDK, NIH
Research Interests
- Mechanism of insulin action and pathogenesis of diabetes, focusing on pancreatic beta cell failure
NIH Grants
MECHANISMS OF ATHEROGENESIS IN INSULIN RESISTANCE (Federal Gov)
Aug 1 2018 - Jun 30 2023
COLUMBIA DIABETES RESEARCH CENTER (Federal Gov)
Jul 6 2018 - Jan 31 2023
ANALYSIS OF BETA CELL DEDIFFERENTIATION USING SCRNA-SEQ OF HUMAN T2D (Federal Gov)
Aug 1 2018 - Jul 31 2021
TRAINING PROGRAM IN ENDOCRINOLOGY AND METABOLISM (Federal Gov)
Jul 1 2015 - Jun 30 2021
CAUSES AND TREATMENT OF -CELL DEDIFFERENTIATION IN DIABETES (Private)
Jul 1 2018 - Jun 30 2021
MECHANISMS OF BETA CELL FAILURE (Federal Gov)
Jun 15 2017 - May 31 2021
ROLE OF FORKHEAD PROTEINS IN INSULIN ACTION (Federal Gov)
Jan 1 2016 - Dec 31 2020
CHARACTERIZING THE DEDIFFERENTIATING BETA CELL IN DIABETES (Federal Gov)
Sep 15 2016 - Sep 14 2020
MOUSE MODELS OF INSULIN RESISTANCE (Federal Gov)
Sep 1 2015 - Aug 31 2020
MOUSE MODELS OF INSULIN RESISTANCE (Federal Gov)
Sep 1 2015 - Aug 31 2020
MOUSE MODELS OF INSULIN RESISTANCE (Federal Gov)
Sep 1 2015 - Aug 31 2020
DIABETES AND ENDOCRINOLOGY RESEARCH CENTER (Federal Gov)
Mar 15 2013 - May 9 2020
ROLE OF FORKHEAD PROTEINS IN INSULIN ACTION (Federal Gov)
Jun 1 2000 - Dec 31 2019
BETA CELL DIFFERENTIATION AS A DIABETES TREATMENT (Private)
Sep 1 2015 - Jun 30 2018
MECHANISMS OF ATHEROGENESIS IN INSULIN RESISTANCE (Federal Gov)
Feb 1 2013 - Jan 31 2018
MECHANISMS OF ATHEROGENESIS IN INSULIN RESISTANCE (Federal Gov)
Feb 1 2013 - Jan 31 2018
DIABETES AND ENDOCRINOLOGY RESEARCH CENTER (Federal Gov)
Mar 15 2013 - Jan 31 2018
DIABETES AND ENDOCRINOLOGY RESEARCH CENTER (Federal Gov)
Mar 15 2013 - Jan 31 2018
MECHANISMS OF ATHEROGENESIS IN INSULIN RESISTANCE (Federal Gov)
Feb 1 2013 - Jan 31 2018
THE ROLE OF FOXO1 IN THE REGULATION OF THE ADIPOCYTE BROWNING RESPONSE (Federal Gov)
Aug 1 2013 - Jul 31 2017
DIACOMPSUMMER STUDENT FUNDING PROGRAM (Federal Gov)
May 1 2017 - Jul 31 2017
THE ROLE OF FOXO1 IN THE REGULATION OF THE ADIPOCYTE BROWNING RESPONSE (Federal Gov)
Aug 1 2013 - Jul 31 2017
MECHANISMS OF BETA CELL FAILURE (Federal Gov)
Jun 1 2013 - Apr 30 2017
MECHANISMS OF BETA CELL FAILURE (Federal Gov)
Jun 1 2013 - Apr 30 2017
MECHANISMS OF BETA CELL FAILURE (Federal Gov)
Jun 1 2013 - Apr 30 2017
MERCK-COLUMBIA (ACCILI) INSULIN SENSITZER AND BETA CELL DEDIFFERENTIATION COLLABORATION (Private)
Dec 14 2015 - Dec 13 2016
GPR17 FUNCTION IN METABOLISM AND SATIETY CONTROL (Federal Gov)
Sep 1 2014 - Aug 31 2016
GPR17 FUNCTION IN METABOLISM AND SATIETY CONTROL (Federal Gov)
Sep 1 2014 - Aug 31 2016
GPR17 FUNCTION IN METABOLISM AND SATIETY CONTROL (Federal Gov)
Sep 1 2014 - Aug 31 2016
DIACOMP SUMMER STUDENT FUNDING PROGRAM (Federal Gov)
Jun 1 2016 - Aug 28 2016
BROWN REMODELING OF WHITE ADIPOSE TISSUE BY PPARGAMMA DEACETYLATION (Federal Gov)
Aug 15 2013 - Aug 14 2016
BROWN REMODELING OF WHITE ADIPOSE TISSUE BY PPARGAMMA DEACETYLATION (Federal Gov)
Aug 15 2013 - Aug 14 2016
SERVIER FELLOWSHIP IN INNOVATIVE DIABETES RESEARCH (Private)
Jul 16 2015 - Jul 15 2016
USE OF HUMAN IPS-DERIVED GUT ORGANOIDS TO CARRY OUT PHENOTYPIC SCREENS FOR INDUCTION OF HORMONE-PRODUCING CELLS (Private)
Apr 1 2014 - Dec 31 2015
AZ IDENTIFY FOX01 INHIBITORS/BLOCKERS THAT PROMOTE ENTEROENDOCRINE CELL DIFFERENTIATION INTO INSULIN-PRODUCING CELLS (Private)
Apr 30 2014 - Dec 31 2015
DIACOMPSUMMER STUDENT FUNDING PROGRAM (Federal Gov)
Jun 1 2015 - Sep 30 2015
DIACOMPSUMMER STUDENT FUNDING PROGRAM (Federal Gov)
Jun 1 2015 - Sep 30 2015
BETA CELL DIFFERENTIATION AS A DIABETES TREATMENT (Private)
Jan 1 2013 - Aug 31 2015
EPGENETIC,PROTEIN, AND CELLULAR BIOMARKERS OF BETA CELL FUNCTION IN T1D (Federal Gov)
Sep 18 2014 - Aug 31 2015
BETA CELL DIFFERENTIATION AS A DIABETES TREATMENT (Private)
Jan 1 2013 - Aug 31 2015
MERCK-COLUMBIA INSULIN SENSITIZER NEW TARGET COLLABORATION (Private)
Jul 8 2014 - Jul 7 2015
ROLE OF GLUT4-EXPRESSING NEURONS IN DIABETES (Private)
Jul 1 2011 - Jun 30 2015
MERCK-COLUMBIA INSULIN SENSITIZER NEW TARGET COLLABORATION (Private)
Dec 3 2012 - Dec 2 2014
MERCK-COLUMBIA INSULIN SENSITIZER NEW TARGET COLLABORATION (Private)
Dec 3 2012 - Dec 2 2014
DIACOMPSUMMER STUDENT FUNDING PROGRAM (Federal Gov)
Jun 1 2014 - Sep 30 2014
DIACOMPSUMMER STUDENT FUNDING PROGRAM (Federal Gov)
Jun 1 2014 - Sep 30 2014
AMGEN RESEARCH COLLABORATION AGREEMENT (Private)
Dec 6 2012 - Dec 5 2013
BREHM COALITION AWARD (Private)
Dec 1 2008 - Nov 30 2013
INSULIN ACTION ON GLUT4 AND FOXO1 IN THE BRAIN (Federal Gov)
Sep 1 2012 - Aug 31 2013
REPROGRAMMING GUT INSULIN-PRODUCING CELLS (Private)
Mar 1 2010 - Feb 29 2012
NOTCH1-FOX01 INTERACTION IN REGULATION OF HEPATIC GLUCONEOGE NESIS (Federal Gov)
Jul 1 2009 - Jul 2 2011
TRANSCRIPTIONAL REGULATION IN DIABETS (Private)
Jul 1 2007 - Jun 30 2011
ROLE OF HEPATIC FOXO1 IN ATHEROSCLEROSIS (Federal Gov)
Sep 13 2010 - May 15 2011