The CCTI at the 2018 Transplantation Society's 28th International Congress

CCTI Director Dr. Megan Sykes will be giving three lectures, beginning with "Utilizing TCR & BCR-Seq to Study Antigen-Specific Immune Responses" in the Basic Science: T Cells session, Saturday, June 30th, 14:15-16:15.  Dr. Sykes will also present a State-of-the-Art Session talk, "Novel Immune Allorecognition Pathways", Monday, July 2nd, 14:45 - 16:15 during the Cutting Edge of Allorecognition Session, and "Xenograft Tolerance" at the Lunch and Learn 2 session, Tuesday, July 3rd from 13:30-14:15.

Also from Dr. Sykes' lab, Dr. Jianing Fu has had all three of her submitted abstracts selected for oral presentation! Her first, "Phenotypic and Clonal Analysis of Recipient B cells and Plasma Cells Entering Graft Mucosa Reveals an Association with Rejection and Evolution towards a Resident Memory Phenotype after Human Intestinal Transplantation" will be presented July 2nd, 8:30-9:30 a.m. (CCTI Director Dr. Megan Sykes presenting) in the B Cell Biology Session. Dr. Fu will then present the other two abstracts in the Chimerism and GVHD Session, July 5th, 9:45-11 a.m. First will be "Role of Graft-derived Graft-versus-Host T cells in Facilitating Multilineage Blood Chimerism after Human Intestinal Transplantation", followed immediately by "Clonal and Functional Analysis Reveals the Capacity of Allograft T cells to Join the Circulating Pool after Human Intestinal Transplantation".

Principal Investigator, Dr. Kazuhiko Yamada will present "Issues relating to clinical xenotransplantation: Is pig genetic engineering essential for the success of xenotransplantation?" Tuesday, July 3, 8:30 a.m. during the Early Morning Symposia on Xenotransplantation. Dr. Yamada will also chair the Campfire Session on "New Approaches in Xenotransplantation" Monday, July 2, 16:30 - 17:30.

The following concurrent oral sessions will be presented by research fellows in Dr. Yamada's lab: 

  • During the Xenotransplantation- Solid Organ session, Hironosuke Watanabe will present, "Transgenic Expression of hCD47 on Vessels in Porcine GalTKO Lung Grafts in Baboons May Mitigate Acute Vascular Rejection in Baboons: Up to 13 Days Graft Survival in Baboons" on July 4th from 09:45 to 10:45 a.m. Dr. Watanabe will also present "Durable Macrochimerism (>8 weeks) and Pig-Specific T and B Cell Unresponsiveness Following hCD47+ Transgenic GalTKO Pig Intra-Bone Bone Marrow Transplantation in Baboons" during the Xenotransplantation: Cell/Tissue and Immune Regulation session the next day, July 5th at 8:30-9:30 a.m.
  • Shunichiro Nomura will present "Transgenic expression of hCD47 minimizes the development of proteinuria following pig-to-baboon kidney transplantation and reduces phagocytosis of porcine endothelial cells and podocytes" also at the Xenotransplantation - Solid Organ session, July 4, from 09:45 to 10:45 a.m.;
  • And Christian Schuetz will speak on "Specific Immunomodulation of Alloantibody Responses", on Junly 2nd at 9:45 a.m

Erik Berglund and Paula Alonso-Guallart of the Griesemer lab will present, respectively, "Induction of Tolerance for Long-Term Liver Allograft Survival Without Immunosuppression in Cynomolgus Monkeys" and "Megadose Bone Marrow and Regulatory T cells for the Induction of Immune Tolerance in Non-Human Primates Through Durable Mixed Hematopoietic Chimerism Across MHC-barriers" during the Preclinical Studies Session, Wednesday, July 4th 8:30-9:30 a.m. Nathaly Llore also of the Griesemer lab, will offer "Recipient T Regulatory Cells Enhance Chimerism and Prolong Galt-KO pig Skin Graft Survival in Baboons", in the Chimerism and GvHD session, July 5th at 9:45 a.m.