Baldwin's Laboratory

Matthew R. Baldwin, MD, MS Assistant Professor of Medicine at Columbia University Medical Center Division of Pulmonary, Allergy, and Critical Care Medicine

Dr. Baldwin’s research is in critical care outcomes with a focus on examining frailty in older ICU survivors of respiratory failure. The overall hypothesis of his research is that outcomes of critical illness in older adults could be dramatically improved by understanding the determinants of those outcomes and patients’ palliative care needs and treatment preferences, and then by designing personalized interventions based on that understanding during the post-ICU care period (which includes post-ICU acute care, post-acute facility care, or home care after hospital discharge).

Dr. Baldwin has received a KL2 award from the Columbia CTSA, a pilot study and a K23 award from the NIA, and was recently received a research fellowship from the Columbia Aging Center at the Columbia University Mailman School of Public Health. Currently, he is recruiting for a prospective cohort study that seeks to determine whether frailty and other measures of neuromuscular function measured near hospital discharge in older ICU survivors are associated independently with post-discharge disability, mortality, and recovery. Future studies will examine palliative care needs of older ICU survivors and the feasibility of a post-ICU palliative care consultation intervention in the week prior to hospital discharge. In addition, Dr. Baldwin collaborates with Dr. Lederer to study associations between potential measures of frailty in lung transplant candidates and post-transplant outcomes. Dr. Baldwin also mentors trainees and advises on clinical research for Columbia University’s Center for Acute Respiratory Failure Extracorporeal Membrane Oxygenation (ECMO).


Selected Peer-Reviewed Publications

  • Baldwin MR, Reid MC, Westlake AA, Rowe JW, Granieri EC, Wunsch H, Dam T, Rabinowitz D, Goldstein N, Maurer MS, Lederer DJ. The feasibility of measuring frailty to predict disability and mortality in older medical-ICU survivors. J Crit Care. 2014 Jun;29(3):401-8.
  • Baldwin MR, Narain WR, Wunsch H, Schluger NW, Cooke JT, Maurer MS, Rowe JW, Lederer DJ, Bach PB. A prognostic model for 6-month mortality in elderly survivors of critical illness. Chest. 2013;143(4):910-9.
  • Berning JB, Poor AD, Buckley SM, Patel KR, Lederer DJ, Goldstein NE, Brodie D, Baldwin MR. A Novel Picture Guide to Improve Spiritual Care and Reduce Anxiety in Mechanically Ventilated Intensive Care Unit Adults. Ann Am Thorac Soc. 2016 April 20. [Epub ahead of print].
  • Baldwin MR, Wunsch H, Reyfman PA, Narain WR, Blinderman CD, Schluger NW, Reid MC, Maurer MS, Goldstein N, Lederer DJ, Bach P. High burden of palliative needs among older ICU survivors transferred to post-acute care facilities: A single center study. Ann Am Thorac Soc. 2013. Oct;10(5): 458-65.
  • Abrams D*, Baldwin MR*, Champion M, Agerstrand C, Eisenberger A, Bacchetta M, Brodie D. Thrombocytopenia and extracorporeal membrane oxygenation in adults with acute respiratory failure: a cohort study. Intensive Care Med. 2016 May;42(5):844-52 *Co-first authors
  • Baldwin MR, Peterson ER, Easthausen I, Quintanilla I, Colago E, Sonett JR, D'Ovidio F, Costa J, Diamond JM, Christie JD, Arcasoy SM, Lederer DJ. Donor age and early graft failure after lung transplantation: A cohort study. Am J Transplant. 2013 Oct; 13(10):2685-95.
  • Baldwin MR, Arcasoy SM, Shah A, Schulze PC, Sze J, Sonett JR, Lederer DJ. Hypoalbuminemia and early mortality after lung transplantation: a cohort study. Am J Transplant. 2012;12(5):1256-67. PMID: 22335491; PMCID: 3628840.