O'Donnell Laboratory

Research Overview

Max O'Donnell, MD, MPH
Assistant Professor
Division of Pulmonary, Allergy, and Critical Care Medicine
Department of Epidemiology

Dr. O'Donnell's research interests are in tuberculosis (TB), HIV, respiratory epidemiology, and global health including ethical issues in global health research. Current research areas include drug-resistant tuberculosis where he has funded research that is basic/translational, and in implementation science, global health education working as Research Director at the East Africa Training Initiative and with Columbia Pulmonary, Critical Care Fellows, Residents, and students, and in the epidemiology of influenza and severe acute respiratory illness in Uganda.

Active collaborators include the KwaZulu-Natal Research Institute on TB/HIV (K-RITH), and the Centre for AIDS Programme of Research in South Africa (CAPRISA), the Jacobs' lab at Albert Einstein College of Medicine, and the Uganda Virus Research Institute (UVRI).

Drug-resistant tuberculosis is an important global public health concern because of increasing incidence, low cure rates, and high reported mortality. Nowhere has this increased incidence generated more concern than in South Africa where interactions between TB and generalized HIV/AIDS epidemics are causing explosive increases in TB incidence and TB case-fatality rates. The most drug-resistant form of tuberculosis, extensively drug resistant tuberculosis (XDR-TB), is increasingly prevalent in South Africa.

Current active funding includes: NIH/NIAID, R01AI114900 Novel Reporter Phages to Detect Complex TB Drug Resistance and Persistence, O’Donnell (Co-investigator); NIH/NIAID R01AI124413 Promoting Engagement in the Drug Resistant TB/HIV Care Continuum in South Africa, O’Donnell (PI); Doris Duke Clinical Scientist Development Award, Louis V. Gerstner Scholars Award.

 

Group Members 

Alison Wolf, MPH, MS
Allison has current projects in the molecular epidemiology of tuberculosis transmission. She also has an active role in the PRAXIS study characterizing and designing interventions to improve adherence for drug-resistant TB and HIV working with collaborators at CAPRISA. Department of Epidemiology

Lorenzo Uccelini PhD
Lorenzo’s background is in genomics, bioinformatics, and viral pathogen discovery. His current work is using a reporter phage to identify rare drug-resistant TB subpopulations in clinical isolates in TB patients on treatment working with collaborators at K-RITH.

Matt Cummings MD
Currently Matt is collaborating with researchers at UVRI, the Lipkin lab and the Jeff Shaman research group (both at the Mailman School of Public Health) to characterize influenza epidemiology and isolate and sequence viral genomes from clinical samples of Ugandan patients with severe acute respiratory infection of unknown etiology.

Christina Hwang

Tanashree Kalghatgi

  

Selected Publications

  1. O'Donnell MR, Daftary A, Frick M, Hirsch-Moverman Y, Amico KR, Senthilingam M, Wolf A, Metcalfe JZ, Isaakidis P, Davis JL, Zelnick JR, Brust JC, Naidu N, Garretson M, Bangsberg DR, Padayatchi N, Friedland G. Re-inventing adherence: toward a patient-centered model of care for drug-resistant tuberculosis and HIV. Int J Tuberc Lung Dis. 2016 Apr;20(4):430-4. PMID: 26970149 PMCID: PMC4863995
  2. Desjardins CA, Cohen KA, Abeel T, Manson McGuire A, Munsamy V, Shea TP, Walker BJ, Bantubani N, Almeida DV, Alvarado L, Chapman SB, Mvelase NR, Duffy EY, Fitzgerald MG, Govender P, Gujja S, Hamilton S, Howarth C, Larimer JD, Maharaj K, Pearson MD, Priest ME, Zeng Q, Padayatchi N, Grosset J, Young SK, Wortman J, Mlisana KP, O'Donnell MR, Birren BW, Bishai WR, Earl AM, Pym AS. Genomic and functional analyses of Mycobacterium tuberculosis strains implicate ald in D-cycloserine resistance. Nature Genetics. Accepted for publication April 2016. PMID: 27064254 [PubMed - in process] PMCID: PMC4848111 [Available on 2016-11-01]
  3. Cohen KA, Abeel T, Manson McGuire A, Desjardins CA, Munsamy V, Shea TP, Walker BJ, Bantubani N, Almeida DV, Alvarado L, Chapman SB, Mvelase NR, Duffy EY, Fitzgerald MG, Govender P, Gujja S, Hamilton S, Howarth C, Larimer JD, Maharaj K, Pearson MD, Priest ME, Zeng Q, Padayatchi N, Grosset J, Young SK, Wortman J, Mlisana KP, O'Donnell MR, Birren BW, Bishai WR, Pym AS, Earl AM. Evolution of Extensively Drug-Resistant Tuberculosis over Four Decades: Whole Genome Sequencing and Dating Analysis of Mycobacterium tuberculosis Isolates from KwaZulu-Natal. PLoS Med. 2015 Sep 29;12(9):e1001880. doi: 10.1371/journal.pmed.1001880. PMID: 26418737 PMCID: PMC4587932
  4. O'Donnell MR, Pillay M, Pillay M, Werner L, Master I, Wolf A, et al. Primary Capreomycin Resistance Is Common and Associated With Early Mortality in Patients With Extensively Drug-Resistant Tuberculosis in KwaZulu-Natal, South Africa. Journal of acquired immune deficiency syndromes. 2015;69(5):536-43. PMID: 25886924 PMCID: PMC4501864 [Available on 2016-08-15]
  5. O'Donnell MR, Pym A, Jain P, Munsamy V, Wolf A, Karim F, et al. A Novel Reporter Phage To Detect Tuberculosis and Rifampin Resistance in a High-HIV-Burden Population. Journal of clinical microbiology. 2015;53(7):2188-94. PMID: 25926493 PMCID: PMC4473227
  6. Cummings M, O’Donnell MR. Inverting the pyramid: increasing awareness of mycobacterial sepsis in sub-Saharan Africa. Int J of Tuberc and Lung Dis. 2015; 19(10):1128-1134. PMID: 26459522 [PubMed - in process] PMCID: PMC4864587