The Pulmonary & Intensive Care Translational Outcomes Research (PICTOR) Group
The Pulmonary & Intensive Care Translational Outcomes Research (PICTOR) Group is a clinical and translational research group led by David J Lederer, MD, MS and Matthew R Baldwin, MD, MS. Our mission is to identify novel risk factors for interstitial lung disease and to improve the lives of lung transplant recipients, adults with advanced lung diseases, and survivors of critical illness. We also seek to train the next generation of clinical and translational investigators in pulmonary and critical care medicine.
The PICTOR Group has 6 Cores:
- Pulmonary Core, directed by David J Lederer, MD, MS, email
- Critical Care Core, directed by Matthew R Baldwin, MD, MS
- Data Analytics Core, directed by Jessica Sell, MPH
- Research Coordination and Regulatory Core, directed by Tatiana Blue
- Translational Research & Biobanking Core, directed by Wen Liu, PhD
- Training & Career Development Core, directed by David J Lederer, MD, MS and Jessica Sell, MPH
We have made novel discoveries about subspecialty care and its role in improving the outcomes of adults living with idiopathic pulmonary fibrosis, disparities in access to subspecialty pulmonary care and lung transplantation, and the impact that body composition and frailty have on older survivors of critical illness and on lung transplantation outcomes.
Clinical and Research Infrastructure Integration
PICTOR is integrated into active clinical programs at Columbia University Medical Center, including the New York Presbyterian/Pulmonary Fibrosis Foundation Interstitial Lung Disease Care Center, the NYP Lung Transplant Program, the Medical Intensive Care Unit at Columbia University, and the CUMC/NYP Scleroderma Program (directed by Elana Bernstein, MD, MS).
PICTOR works closely with existing research infrastructure and services at CUMC, including the CTSA-funded Irving Institute for Clinical and Translational Research, the Mailman School of Public Health’s Patient-Oriented Research Master’s degree program, the Office of Clinical Trials, and the CUMC Institutional Review Board.
What We Do
The PICTOR Group conducts clinical and translational research in the following areas:
- Using population-based studies, such as the Multi-Ethnic Study of Atherosclerosis (MESA), we are examining the causes of lung injury, inflammation, and fibrosis in humans.
- We are examining the roles of obesity, body composition, and frailty in early lung transplant outcomes.
- We are performing early work examining obstructive sleep apnea and its contribution to subclinical alveolar epithelial cell injury and consequent fibrosis.
- We are examining disparities in access to subspecialty pulmonary care and lung transplantation in the United States.
- We are examining the unmet palliative care needs of ICU survivors as they relate to frailty status.
- We are examining racial and socioeconomic outcome disparities among older survivors of critical illness.
Who We Are
David J Lederer, MD, MS, Director, Pulmonary and Training/Career Development Cores
Matthew R Baldwin, MD, MS, Director, Critical Care Core
Darryl Abrams, MD
Selim Arcasoy, MD, MPH
R Graham Barr, MD, DrPH
Joan Bathon, MD
Elana Bernstein, MD, MS
Daniel Brodie, MD
Jon Giles, MD, MPH
Max O’Donnell, MD, MPH
Dan Rabinowitz, PhD
Kashif Raza, MD
Hilary Robbins, MD
Lori Shah, MD
Jeremy Weingarten, MD, MPH
Hans-Willem Snoeck, MD, PhD
PICTOR Fellows & Trainees
Purnema Madahar, MD
Anna Podolanczuk, MD
Armeen Poor, MD
Michaela Restivo, MD
Mark Snyder, MD
Ashley Tabah, MPH candidate
Min Wu, MPH candidate
Tatiana Blue, Director, Research Coordination and Regulatory Core
Wen Liu, PhD, Director, Translational Research & Biobanking Core
Amika McBurnie, MPH
Jessica Sell, MPH, Director, Data Analytics Core & Co-Director, Training & Career Development
Prior Trainees and Staff
Emma KT Benn, DrPH
Bianca Harris, MD, MS
Jaime Hook, MD
Daniela Lamas, MD
Sunny Lim, MD
Jeffrey Okun, MD
Eric Peterson, MPH
Debbie Rybak, MD
Rupal Shah, MD
Christopher Winterbottom, MD
- Singer JP, Diamond JM, Gries CJ, McDonnough J, Blanc PD, Shah R, Dean MY, Hersh B, Wolters PJ, Tokman S, Arcasoy SM, Ramphal K, Greenland JR, Smith N, Heffernan P, Shah L, Shrestha P, Golden JA, Blumenthal N, Huang D, Sonett J, Hays S, Oyster M, Katz PP, Robbins H, Brown M, Leard LE, Kukreja J, Bacchetta M, Bush E, D'Ovidio F, Rushefski M, Raza K, Christie JD, Lederer DJ. Frailty phenotypes, disability, and outcomes in adult candidates for lung transplantation. Am J Respir Crit Care Med. In press. [Abstract]
- Bernstein EJ, Peterson ER, Sell JL, D'Ovidio F, Arcasoy SM, Bathon JM, Lederer DJ. Survival of adults with systemic sclerosis following lung transplantation: A nationwide cohort study. Arthritis Rheumatol 2015; 67(5):1314-22. [Abstract]
- Singer JP, Peterson ER, Snyder ME, Katz PP, Golden JA, D'Ovidio F, Bacchetta M, Sonett JR, Kukreja J, Shah L, Robbins H, Van Horn K, Shah RJ, Diamond JM, Wickersham N, Sun L, Hays S, Arcasoy SM, Palmer SM, Ware LB, Christie JD, Lederer DJ. Body Composition and Mortality after Adult Lung Transplantation in the United States. Am J Respir Crit Care Med 2014;190(9):1012-21. [Abstract] [Full text]
- Baldwin MR, Reid MC, Westlake AA, Rowe JW, Granieri EC, Wunsch H, Dam T, Rabinowitz D, Goldstein N, Maurer MS, Lederer DJ. The feasibility of measuring frailty to predict disability and mortality in older medical-ICU survivors. J Crit Care. 2014 Jun;29(3):401-8. [Abstract] [Full text]
- Baldwin MR, Wunsch H, Reyfman PA, Narain WR, Blinderman CD, Schluger NW, Reid MC, Maurer MS, Goldstein N, Lederer DJ, Bach P. High burden of palliative needs among older ICU survivors transferred to post-acute care facilities: A single center study. Ann Am Thorac Soc. 2013. Oct;10(5): 458-65. PMID: 23987743; PMCID: 3960912. [Abstract] [Full text]
- Baldwin MR, Narain WR, Wunsch H, Schluger NW, Cooke JT, Maurer MS, Rowe JW, Lederer DJ, Bach PB. A prognostic model for 6-month mortality in elderly survivors of critical illness. Chest. 2013;143(4):910-9. PMID: 23632902; PMCID: 3616685. [Abstract] [Full text]
- Baldwin MR, Peterson ER, Easthausen I, Quintanilla I, Colago E, Sonett JR, D'Ovidio F, Costa J, Diamond JM, Christie JD, Arcasoy SM, Lederer DJ. Donor age and early graft failure after lung transplantation: a cohort study. Am J Transplant 2013;13(10):2685-95. [Abstract] [Full text]
- Ventetuolo C, Kawut SM, Lederer DJ. Plasma endothelin-1 and vascular endothelial growth factor levels and their relationship to hemodynamics in idiopathic pulmonary fibrosis. Respiration 2012;84(4):299-305. [Abstract] [Full text]
- Weingarten JA, Lederer DJ, Ozturk E, Milite F, Mooney AM, Thomashow BM, Basner RC. A comparison of single breath and re-breathe diffusing capacity in emphysema patients and controls. Respir Physiol Neurobiol 2012;183(1):15-9. [Abstract]
- Baldwin, MR, Arcasoy SM, Shah A, Sze J, Sonett JR, Lederer DJ. Hypoalbuminemia and early mortality after lung transplantation: a cohort study. Am J Transplant 2012;12(5):1256-67. [Abstract] [Full text]
- Hook JL, Arcasoy SM, Zemmel D, Bartels M, Kawut SM, Lederer DJ. Titrated oxygen requirement and prognostication in idiopathic pulmonary fibrosis. Eur Respir J 2012;39(2):359-65. [Abstract] [Full text]
- Lederer DJ, Kawut S, Wikersham N, Winterbottom C, Bhorade S, Palmer S, Lee J, Diamond J, Wille K, Weinacker A, Lama V, Crespo M, Orens J, Sonett J, Arcasoy S, Ware L, Christie J. Obesity and primary graft dysfunction after lung transplantation: the LTOG Obesity Study. Am J Respir Crit Care Med 2011;184:1055-61. [Abstract] [Full text]
- Lamas DJ, Kawut SM, Bagiella E, Philip N, Arcasoy SM, Lederer DJ. Delayed access and survival in idiopathic pulmonary fibrosis: a cohort study. Am J Respir Crit Care Med 2011;184:842-7. [Abstract] [Full text]
- Lederer DJ, Enright PL, Kawut SM, Hoffman EA, Hunninghake G, van Beek EJR, Austin JHM, Jiang R, Lovasi GS, Barr RG. Cigarette smoking is associated with subclinical parenchymal lung disease: The MESA-Lung Study. Am J Respir Crit Care Med 2009;180(5):407-14. [Abstract] [Full text]
- Lederer DJ, Wilt JS, D'Ovidio F, Bacchetta M, Shah L, Ravichandran S, Lenoir J, Klein B, Sonett JR, Arcasoy SM. Obesity and underweight are associated with an increased risk of death after lung transplantation. Am J Respir Crit Care Med 2009;180(9):887-95. [Abstract] [Full text]
- Lederer DJ, Jelic S, Basner RC, Ishizaka A, Bhattacharya J. Circulating KL-6, a biomarker of lung injury, in obstructive sleep apnea. Eur Respir J 2009;33(4):793-6. [Abstract] [Full text]
- Lederer DJ, Benn EKT, Barr RG, Wilt JS, Reilly G, Sonett JR, Arcasoy SM, Kawut SM. Racial differences in waiting list outcomes in COPD. Am J Respir Crit Care Med 2008;177(4):450-454. [Abstract] [Full text]
- Lederer DJ, Arcasoy SM, Barr RG, Wilt JS, Bagiella E, D'Ovidio F, Sonett JR, Kawut SM. Racial and ethnic disparities in idiopathic pulmonary fibrosis: A UNOS/OPTN database analysis. Am J Transplant 2006;6(10):2436-42. [Abstract] [Full text]
- Lederer DJ, Arcasoy SM, Wilt JS, D'Ovidio F, Sonett JR, Kawut SM. Six-minute walk distance predicts waiting list survival in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2006;174(6):659-64. [Abstract] [Full text]
PICTOR is funded by the National Institutes of Health, multiple industry sponsors, and private donors, including the following generous support:
- R01 HL114626: Obesity, Inflammation, and Lung Injury after Lung Transplantation (PI: Lederer/Christie)
- R01 HL087115: Clinical Risk Factors for Primary Graft Dysfunction (PI: Christie; site PI: Lederer)
- R01 HL114468: Foxp3+ Treg Cells & Primary Graft Dysfunction in Clinical Lung Tx Recipients (PI: Hancock; site PI: Lederer)
- R01 HL103676: Subclinical Interstitial Lung Disease in MESA (PI: Lederer)
- U54 HL127672: Rare Lung Disease Consortium: Molecular Pathway-Driven Diagnostics & Therapeutics for Rare Lung Diseases, Hermansky-Pudlak Syndrome Project (overall PI: Trapnell; subproject PI: Young; site PI: Lederer)
- American Federation for Aging Research/NIA Medical Student Training in Aging Research (MSTAR) Program at Weill Cornell Medical College (PI: Reid; Mentor: Baldwin; Recipient: Pollack)
Columbia Physicians & Surgeons Dean’s Research Fellowship (Mentor: Baldwin; Recipient: Pollack)
Although we have been fortunate enough to receive support from the National Institutes of Health and from non-profit foundations, we rely heavily on support from individuals. Your support helps us in our journey to identify the causes of pulmonary fibrosis, make lung transplantation safer, and improve the lives of adults who survive critical illness.
Please consider making a donation. Checks can be made out to “The Trustees of Columbia University in the City of New York” and mailed to:
Columbia University Medical Center
Division of Pulmonary, Allergy, and Critical Medicine
622 W 168th Street, PH 9-215
New York, NY 10032
Please note “PICTOR research” in the memo line. You can always reach out to us directly to discuss a donation or gift at 212-342-4167.