The Pulmonary & Intensive Care Translational Outcomes Research (PICTOR) Group

 

Overview

The Pulmonary & Intensive Care Translational Outcomes Research (PICTOR) Group is a clinical and translational research group led by David J Lederer, MD, MS and Matthew R Baldwin, MD, MS. Our mission is to identify novel risk factors for interstitial lung disease and to improve the lives of lung transplant recipients, adults with advanced lung diseases, and survivors of critical illness. We also seek to train the next generation of clinical and translational investigators in pulmonary and critical care medicine.

The PICTOR Group has 6 Cores:

  • Pulmonary Core, directed by David J Lederer, MD, MS
  • Critical Care Core, directed by Matthew R Baldwin, MD, MS
  • Data Analytics Core, directed by Arindam RoyChoudhury, PhD
  • Research Coordination and Regulatory Core, directed by Tatiana Blue
  • Translational Research & Biobanking Core, directed by Matthew Lippel
  • Training & Career Development Core, directed by David J Lederer, MD, MS 

We have made novel discoveries about subspecialty care and its role in improving the outcomes of adults living with idiopathic pulmonary fibrosis, disparities in access to subspecialty pulmonary care and lung transplantation, and the impact that body composition and frailty have on older survivors of critical illness and on lung transplantation outcomes.

For more information, please contact Dr. Lederer [dl427@cumc.columbia.edu] or Dr. Baldwin [mrb45@cumc.columbia.edu].

Clinical and Research Infrastructure Integration

PICTOR is integrated into active clinical programs at Columbia University Medical Center, including the New York Presbyterian/Pulmonary Fibrosis Foundation Interstitial Lung Disease Care Center, the NYP Lung Transplant Program, the Medical Intensive Care Unit at Columbia University, and the CUMC/NYP Scleroderma Program (directed by Elana Bernstein, MD, MS).

PICTOR works closely with existing research infrastructure and services at CUMC, including the CTSA-funded Irving Institute for Clinical and Translational Research, the Mailman School of Public Health’s Patient-Oriented Research Master’s degree program, the Office of Clinical Trials, and the CUMC Institutional Review Board.

What We Do

The PICTOR Group conducts clinical and translational research in the following areas:

  1. Using population-based studies, such as the Multi-Ethnic Study of Atherosclerosis (MESA), we are examining the causes of lung injury, inflammation, and fibrosis in humans.
  2. We are examining the roles of obesity, body composition, and frailty in early lung transplant outcomes.
  3. We are performing early work examining obstructive sleep apnea and its contribution to subclinical alveolar epithelial cell injury and consequent fibrosis.
  4. We are examining disparities in access to subspecialty pulmonary care and lung transplantation in the United States.
  5. We are examining the unmet palliative care needs of ICU survivors as they relate to frailty status.
  6. We are examining racial and socioeconomic outcome disparities among older survivors of critical illness.

Who We Are

Leadership
David J Lederer, MD, MS, Director, Pulmonary and Training/Career Development Cores
Matthew R Baldwin, MD, MS, Director, Critical Care Core

Core and Affililated Faculty
Darryl Abrams, MD
Selim Arcasoy, MD, MPH
R Graham Barr, MD, DrPH
Joan Bathon, MD
Elana Bernstein, MD, MS
Daniel Brodie, MD
Jon Giles, MD, MPH
Aimee Layton, PhD
Max O’Donnell, MD, MPH
Dan Rabinowitz, PhD
Kashif Raza, MD
Hilary Robbins, MD
Arindam RoyChoudhury, PhD
Lori Shah, MD
Jeremy Weingarten, MD, MPH
Hans-Willem Snoeck, MD, PhD

PICTOR Fellows & Trainees
Purnema Madahar, MD
Dawn Maldonado
Anna Podolanczuk, MD
Lauren Pollack
Michaela Restivo, MD
Mark Snyder, MD

PICTOR Staff
Tatiana Blue, Director, Research Coordination and Regulatory Core
Imaani Easthausen
Wendy Gonzalez
Matthew Lippel, Director, Translantional Research & Biobanking Core
Amika McBurnie, MPH

Prior Trainees and Staff
Emma KT Benn, DrPH
Jerson Cochancela
Amisha Desai
Madeleine Drusin
Amy Giunta
Bianca Harris, MD, MS
Jaime Hook, MD
Katie Jones
Daniela Lamas, MD
Megan Larkin
Sunny Lim, MD
Wen Liu, PhD
Alessa Messineo
Jeffrey Okun, MD
Eric Peterson, MPH
Armeen Poor, MD
Nisha Philip
Isaac Quintanilla
Debbie Rybak, MD
Shefali Sanyal
Rupal Shah, MD
Jessica Sell, MPH
Ashley Tabah, MPH
Wendy Tang
Jaya Tiwari
Christopher Winterbottom, MD
Min Wu, MPH

Selected Publications

 

  1. Diamond JM, Arcasoy S, McDonnough JA, Sonnett JR, Bacchetta M, D'Ovidio F, Cantu E 3rd, Bermudez CA, McBurnie A, Rushefski M, Kalman LH, Oyster M, D'Errico C, Suzuki Y, Giles JT, Ferrante A, Lippel M, Singh G, Lederer DJ, Christie JD. Adipose gene expression profile changes with lung allograft reperfusion. Am J Transplant. In press. [Abstract] [Full text]
  2. Podolanczuk AJ, Oelsner EC, Barr RG, Hoffman EA, Armstrong HF, Austin JH, Basner RC, Bartels MN, Christie JD, Enright PL, Gochuico BR, Hinckley Stukovsky K, Kaufman JD, Hrudaya Nath P, Newell JD Jr, Palmer SM, Rabinowitz D, Raghu G, Sell JL, Sieren J, Sonavane SK, Tracy RP, Watts JR, WIlliams K, Kawut SM, Lederer DJ. High attenuation areas on chest computed tomography in community-dwelling adults: the MESA study. Eur Respir J. In press. [Abstract] [Full text]
  3. Berning JN, Poor AD, Buckley SM, Patel KR, Lederer DJ, Goldstein NE, Brodie D, Baldwin MR. A novel picture guide to improve spiritual care and reduce anxiety in mechanically ventilated adults in the intensive care unit. Ann Am Thorac Soc. 2016;13(8)1333-42. [Abstract] [Full text]
  4. Sell JL, Bacchetta M, Goldfarb SB, Park H, Heffernan PV, Robbins HA, Shah L, Raza K, D'Ovidio F, Sonnett JF, Arcasoy SM, Lederer DJ. Short stature and access to lung transplantation in the United States: a cohort study. Am J Respir Crit Care Med. 2016;193(6)681-8. [Abstract] [Full text]
  5. Weingarten JA, Dubrovsky B, Basner RC, Redline S, George L, Lederer DJ. Polysomnographic measurement of sleep duration and bodily pain perception in the sleep heart health study. Sleep. 2016;39(8)1583-9. [Abstract] [Full text]
  6. Singer JP, Diamond JM, Gries CJ, McDounnough J, Blanc PD, Shah R, Dean MY, Hersh B, Wolters PJ, Tokman S, Arcasoy SM, Ramphal K, Greenland JR, Smith N, Heffernan P, Shah L, Shrestha P, Golden JA, Blumenthal NP, Huang D, Sonett J, Hays S, Oyster M, Katz PP, Robbins H, Brown M, Leard LE, Kukreja J, Bacchetta M, Bush E, D'Ovidio F, Rushefski M, Raza K, Christie JD, Lederer DJ. Frailty phenotypes, disability, and outcomes in adult candidates for lung transplantation. Am J Respir Crit Care Med 2015;192(11)1325-34. [Abstract] [Full text]
  7. Bernstein EJ, Peterson ER, Sell JL, D'Ovidio F, Arcasoy SM, Bathon JM, Lederer DJ. Survival of adults with systemic sclerosis following lung transplantation: A nationwide cohort study. Arthritis Rheumatol 2015; 67(5):1314-22. [Abstract] [Full text]
  8. Singer JP, Peterson ER, Snyder ME, Katz PP, Golden JA, D'Ovidio F, Bacchetta M, Sonett JR, Kukreja J, Shah L, Robbins H, Van Horn K, Shah RJ, Diamond JM, Wickersham N, Sun L, Hays S, Arcasoy SM, Palmer SM, Ware LB, Christie JD, Lederer DJ. Body Composition and Mortality after Adult Lung Transplantation in the United States. Am J Respir Crit Care Med 2014;190(9):1012-21. [Abstract] [Full text
  9. Baldwin MR, Reid MC, Westlake AA, Rowe JW, Granieri EC, Wunsch H, Dam T, Rabinowitz D, Goldstein N, Maurer MS, Lederer DJ. The feasibility of measuring frailty to predict disability and mortality in older medical-ICU survivors. J Crit Care. 2014 Jun;29(3):401-8. [Abstract] [Full text
  10. Baldwin MR, Wunsch H, Reyfman PA, Narain WR, Blinderman CD, Schluger NW, Reid MC, Maurer MS, Goldstein N, Lederer DJ, Bach P. High burden of palliative needs among older ICU survivors transferred to post-acute care facilities: A single center study. Ann Am Thorac Soc. 2013. Oct;10(5): 458-65. PMID: 23987743; PMCID: 3960912. [Abstract] [Full text
  11. Baldwin MR, Narain WR, Wunsch H, Schluger NW, Cooke JT, Maurer MS, Rowe JW, Lederer DJ, Bach PB. A prognostic model for 6-month mortality in elderly survivors of critical illness. Chest. 2013;143(4):910-9. PMID: 23632902; PMCID: 3616685. [Abstract] [Full text
  12. Baldwin MR, Peterson ER, Easthausen I, Quintanilla I, Colago E, Sonett JR, D'Ovidio F, Costa J, Diamond JM, Christie JD, Arcasoy SM, Lederer DJ. Donor age and early graft failure after lung transplantation: a cohort study. Am J Transplant 2013;13(10):2685-95. [Abstract] [Full text
  13. Ventetuolo C, Kawut SM, Lederer DJ. Plasma endothelin-1 and vascular endothelial growth factor levels and their relationship to hemodynamics in idiopathic pulmonary fibrosis. Respiration 2012;84(4):299-305. [Abstract] [Full text
  14. Weingarten JA, Lederer DJ, Ozturk E, Milite F, Mooney AM, Thomashow BM, Basner RC. A comparison of single breath and re-breathe diffusing capacity in emphysema patients and controls. Respir Physiol Neurobiol 2012;183(1):15-9. [Abstract] [Full text]
  15. Baldwin, MR, Arcasoy SM, Shah A, Sze J, Sonett JR, Lederer DJ. Hypoalbuminemia and early mortality after lung transplantation: a cohort study. Am J Transplant 2012;12(5):1256-67. [Abstract] [Full text
  16. Hook JL, Arcasoy SM, Zemmel D, Bartels M, Kawut SM, Lederer DJ. Titrated oxygen requirement and prognostication in idiopathic pulmonary fibrosis. Eur Respir J 2012;39(2):359-65. [Abstract] [Full text
  17. Lederer DJ, Kawut S, Wikersham N, Winterbottom C, Bhorade S, Palmer S, Lee J, Diamond J, Wille K, Weinacker A, Lama V, Crespo M, Orens J, Sonett J, Arcasoy S, Ware L, Christie J. Obesity and primary graft dysfunction after lung transplantation: the LTOG Obesity Study. Am J Respir Crit Care Med 2011;184:1055-61. [Abstract] [Full text
  18. Lamas DJ, Kawut SM, Bagiella E, Philip N, Arcasoy SM, Lederer DJ. Delayed access and survival in idiopathic pulmonary fibrosis: a cohort study. Am J Respir Crit Care Med 2011;184:842-7. [Abstract] [Full text
  19. Lederer DJ, Enright PL, Kawut SM, Hoffman EA, Hunninghake G, van Beek EJR, Austin JHM, Jiang R, Lovasi GS, Barr RG. Cigarette smoking is associated with subclinical parenchymal lung disease: The MESA-Lung Study. Am J Respir Crit Care Med 2009;180(5):407-14. [Abstract] [Full text
  20. Lederer DJ, Wilt JS, D'Ovidio F, Bacchetta M, Shah L, Ravichandran S, Lenoir J, Klein B, Sonett JR, Arcasoy SM. Obesity and underweight are associated with an increased risk of death after lung transplantation. Am J Respir Crit Care Med 2009;180(9):887-95. [Abstract] [Full text
  21. Lederer DJ, Jelic S, Basner RC, Ishizaka A, Bhattacharya J. Circulating KL-6, a biomarker of lung injury, in obstructive sleep apnea. Eur Respir J 2009;33(4):793-6. [Abstract] [Full text
  22. Lederer DJ, Benn EKT, Barr RG, Wilt JS, Reilly G, Sonett JR, Arcasoy SM, Kawut SM. Racial differences in waiting list outcomes in COPD. Am J Respir Crit Care Med 2008;177(4):450-454. [Abstract] [Full text
  23. Lederer DJ, Arcasoy SM, Barr RG, Wilt JS, Bagiella E, D'Ovidio F, Sonett JR, Kawut SM. Racial and ethnic disparities in idiopathic pulmonary fibrosis: A UNOS/OPTN database analysis. Am J Transplant 2006;6(10):2436-42. [Abstract] [Full text
  24. Lederer DJ, Arcasoy SM, Wilt JS, D'Ovidio F, Sonett JR, Kawut SM. Six-minute walk distance predicts waiting list survival in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2006;174(6):659-64. [Abstract] [Full text

View all publications by Dr. Lederer and Dr. Baldwin

Funding

PICTOR is funded by the National Institutes of Health, multiple industry sponsors, and private donors, including the following generous support:

Donate

Although we have been fortunate enough to receive support from the National Institutes of Health and from non-profit foundations, we rely heavily on support from individuals. Your support helps us in our journey to identify the causes of pulmonary fibrosis, make lung transplantation safer, and improve the lives of adults who survive critical illness.

Please consider making a donation. Checks can be made out to “The Trustees of Columbia University in the City of New York” and mailed to:

    Tatiana Blue
    Columbia University Medical Center
    Division of Pulmonary, Allergy, and Critical Medicine
    622 W 168th Street, PH 9-215
    New York, NY 10032

Please note “PICTOR research” in the memo line. You can always reach out to us directly to discuss a donation or gift at 212-342-4167.