Cardoso Laboratory

Research Overview

My research focuses on the regulation of progenitor cell fate and morphogenesis in the developing lung and the contribution of developmental mechanisms to lung disease and regeneration-repair of the adult lung. For nearly two decades my laboratory has been investigating the role of developmental pathways, including retinoic acid, Fgf, Tgf beta and Notch, in the establishment of cell fate and patterning of the embryonic lung. These studies have provided insights into specific gene regulatory networks that control lung progenitor cell fate and expansion, airway branching and differentiation of the lung progenitors into the multiple epithelial cell lineages.

A major effort of my lab has been to understand the mechanisms of induction and diversification of airway epithelial cell phenotypes and the impact of these mechanisms in human health and disease. This research provided opportunity for productive interactions with a multidisciplinary team of investigators during my tenure as Principal Investigator and Director of the Program in Lung Development and Progenitor Cell Biology at the Pulmonary Center, Boston University School of Medicine.

I have recently joined the faculty of the Departments of Medicine and Genetics and Development at Columbia University and became Director of the Columbia Center for Human Development (CCHD). The Center is a new research hub recently established by the Department of Medicine that integrates basic and clinical scientists across the medical campus to advance knowledge on mechanisms of normal development and the understanding of the developmental basis of human disease.

Wellington V. Cardoso, MD, PHD
Professor of Medicine and Genetics & Development Director, Columbia Center for Human Development

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