Wellington V. Cardoso, M.D., PhD

Professor of Medicine and Genetics & Development
Director, Columbia Center for Human Development

Cardoso's Laboratory
650 West 168th Street
BB 8-812
New York, NY 10032
P: (212) 342-3971

Dr. Cardoso's C.V.

Bio

Wellington V. Cardoso, MD, PhD, is the Director of the Columbia Center for Human Development, Professor of Medicine at the Division of Pulmonary and Critical Care Medicine, Department of Medicine, and Professor of Genetics and Development at Columbia University Medical Center.

Dr. Cardoso’s research focuses on the mechanisms that control lung development, regeneration-repair and the role of developmental signaling in pulmonary diseases. For nearly two decades his laboratory has been making relevant contributions to the field, providing insights into how regulators, such as retinoic acid, Fgf, Hippo-Yap and Notch influence lung progenitor cell fate, morphogenesis and epithelial differentiation. These studies identified developmental signals crucial for progenitor cell expansion and differentiation of lung epithelial cell types, the molecular mechanisms associated with lung agenesis in vitamin A deficiency, the Notch-mediated mechanisms that balance the distinct cell types in developing and adult airways shown to be abnormal in chronic respiratory diseases, and the impact of prenatal fetal exposures to low Vitamin A levels in the susceptibility of the adult lung to asthma-like hyperresponsiveness. Current interests include enhanced understanding of the ontogeny and molecular events that lead to lineage commitment of basal cells to an airway–specific program, the identification of novel components of the endogenous airway progenitor/stem cell pool in mice and humans and their role in pulmonary diseases. Over the course of his career as a Principal Investigator, Dr. Cardoso has received multiple NIH R01 and Program Project grants. Recent awards include a R35-NHLBI Outstanding Investigator grant and the Columbia University Medical Center Irene & Arthur Fishberg Prize 2017, for his leadership and contributions to the field. He has served as Chair and reviewer in multiple NIH study section committees and as an invited speaker in national and international research conferences world-wide.

Education and Training

Medical School:
University of Brasilia, Brazil, 1981
Residency:
Pathology, University of Brasilia, Brazil, 1981
PhD Degree:
University of Sao Paulo, Brazil, 1984
Postdoctoral Fellowship:
University of British Columbia, Vancouver (Canada), 1991
Pulmonary Center, Boston University, Boston, MA,1993

Professional Experience & Honors

  • 2017 Irene and Arthur Fishberg Prize, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY
  • 2013 – Present Director, Columbia Center for Human Development Columbia University Medical Center, New York, NY
  • 2008 – 2013 Director, Program in Lung Development & Progenitor Cell Biology, Pulmonary Center, Boston University School of Medicine Boston, MA
  • 2008 – 2009 Associate Director, Pulmonary Center, Boston Univ. School of Medicine
  • 2007-2013 Executive Committee, Pulmonary Center, Boston University School of Medicine
  • 2012 Chair-Elect organizer FASEB Summer Research Conference: “The Lung Epithelium in Health and Disease,” Saxton Rivers VT
  • 2013-present NIH-NHLBI – Lung Injury Repair Regeneration (LIRR) – Study section member
  • 2013 Session Chair: Gordon Research Conference on Lung Development, Injury & Repair. “Building the Lung,” Andover, NH
  • 2010-2014 NIH-NHLBI Progenitor Cell Biology Consortium, External Advisory Committee
  • 2010-12 American Thoracic Society, Respiratory Cell Molecular Biology Assembly Planning Committee
    2011 Co-Chair, NIH-NHLBI - Workshop on “Molecular Determinants of Lung, Development,” Bethesda, MD
  • 2011 Chair, Session: “Genetic Programs Driving Lung Development and Regeneration”, American Thoracic Society Meeting, Denver, CO
  • 2010 Session Chair: FASEB Summer Research Conference: Symposium: “Molecular Regulation of Lung Development and Other Programmatic Signals” Saxton Rivers, VT

Research

Contact Information: 

Cardoso's Laboratory
650 West 168th Street
BB 8-812
New York, NY 10032
P: (212) 342-3971
wvc2104@columbia.edu

Lab Manager: Rashmi Patel
P: (212) 305-7310
F: (212) 305-6701
E: rnp2105@columbia.edu

Assistant: Kathryn Kennedy
P: (212) 305-1731

Research Interests

Research in the Cardoso’s lab focuses on the regulation of lung development, regeneration-repair and developmental signaling in lung diseases. Current studies include:

  • Analyses of the molecular and cellular events leading to the ontogeny of the airway stem cell compartment.
  • Identification of novel components of the endogenous airway progenitor/stem cell pool in mice and humans and their potential role in pulmonary disease pathogenesis.
  • Control of differentiation and diversification of multiciliated cells in developing airways and in adult pulmonary diseases.
  • Identification of biomarkers and regulators of early biological changes in the lung parenchyma leading to interstitial lung disease - pulmonary fibrosis.
  • Hippo-Yap regulation of lung development and disease.
     

Selected Publications

  1. van Soldt BJ, Qian J, Li J, Tang N, Lu J, Cardoso WV. Yap and its subcellular localization have distinct compartment-specific roles in the developing lung. Development. 2019, 146(9). pii: dev175810. doi: 10.1242/dev.175810.
    PMID: 30944105
  2. Yang Y, Riccio P, Schotsaert M, Mori M, Lu J, Lee DK, García-Sastre A, Xu J, Cardoso WV. Spatial-Temporal Lineage Restrictions of Embryonic p63+ Progenitors Establish Distinct Stem Cell Pools in Adult Airways. Developmental Cell. 2018 Mar 26;44(6):752-761.e4. doi:10.1016/j.devcel.2018.03.001. PMID: 29587145.
  3. Yang Y, Cardoso WV. Stem Cells Sheltered from Air-Raids Repair Airways. Cell Stem Cell. 2018 May 3;22(5):613-614. Doi: 10.1016/j.stem.2018.04.010. PMID:29727674.
  4. Mori M, Hazan R, Danielian PS, Mahoney JE, Li H, Lu J, Miller ES, Zhu X, Lees JA, Cardoso WV. Cytoplasmic E2f4 forms organizing centres for initiation of centriole amplification during multiciliogenesis. Nature Communications. 2017 Jul 4;8:15857. Doi: 10.1038/ncoms 15857. PMID: 28675157.
  5. Guha A, Deshpande A, Jain A, Sebastiani P, Cardoso WV. Uroplakin 3a+ Cells Are a Distinctive Population of Epithelial Progenitors that Contribute to Airway Maintenance and Post-injury Repair. Cell Reports. 2017 Apr 11;19(2):246-254. Doi: 10.1016/j.celrep.2017.03.051. PMID: 28402849.
  6. Tsao PN, Matsuoka C, Wei SC, Sato A, Sato S, Hasegawa K, Chen HK, Ling TY, Mori M, Cardoso WV, Morimoto M. Epithelial Notch signaling regulates lung alveolar morphogenesis and airway epithelial integrity. Proc Natl Acad Sci, USA. 2016 Jun 30. Pii: 201511236 PMID: 27364009
  7. Chen F, Marquez, H, Kim YK, , Qian J, Shao F, Cruikshank K, Quadro L, Cardoso WV. Prenatal retinoid deficiency leads to airway hyperresponsiveness in adult mice. J. Clinical Investigation. 124:801-11. 2014. PMID: 24401276
  8. Guha A, Vasconcelos M. Cai Y, Yoneda M, Hinds, Qian J, Li G, Dickel L, Johnson JE, Kimura S, Guo J, McMahon J, McMahon AP, Cardoso WV. The neuroepithelial body microenvironment is a niche for a distinct subset of Clara-like precursors in the developing airways. Proc. Natl. Acad. Sci. USA. 109:12592-12597, 2012
  9. Tsao PN, Wei SC, Wu MF, Huang MT, Lin HY, Lee MC, Lin KMC, Wang IJ, Kaartinen V, Yang LT, Cardoso WV. Notch signaling prevents mucous metaplasia in mouse conducting airways during postnatal development. Development, 138:3533-43, 2011. PMID: 21791528.
  10. Chen F, Cao Y, Qian J, Shao F, Niederreither K, Cardoso WV. A retinoic acid-dependent network in the foregut controls formation of the mouse lung primordium. J. Clinical Investigation.120:2040-8. 2010 PMID: 20484817
  11. Tsao PN, Vasconcelos M, Izvolsky KI, Qian J, Lu J, Cardoso WV. Notch signaling controls the balance of ciliated and secretory cell fates in developing airways. Development 136: 2297-2307, 2009. PMID: 19502490
  12. Cardoso, WV and Lu, J. Regulation of early lung development: questions, facts and controversies. Development 133: 1161-1624, 2006. PMID: 16613830

View Dr. Cardoso's full list of publications from PubMed