Rachel L. Miller, M.D.

Professor of Medicine (In Pediatrics) and Environmental Health Sciences
Director, Division of Pediatric Allergy and Immunology
Director, Allergy and Immunology Fellowship Program
Director, Asthma Project
Co-Deputy Director, CCCEH


Dr. Miller is board certified in Internal Medicine, Pulmonary Disease, Critical Care Medicine and Allergy and Immunology. She has appointments in 3 departments in 2 Columbia schools and is the Director of the Allergy and Immunology Fellowship program and Director of Adult Allergy. She was named as top pulmonologist in the 2011 US News and World Report report and is a Fellow at the American Academy of Allergy Asthma and Immunology. Her clinical office specializes in the treatment of asthma and allergies at the John Edsall-John Wood Asthma Center.

In addition, Dr. Miller is the Co-Deputy Director of the Columbia Center for Childrens Environmental Health (CCCEH), and Associate Director and Lead Physician Scientist for the Disease Investigation through Specialized Clinically-Oriented Ventures in Environment Research (DISCOVER). Her research concentrates on the mechanisms for the onset of asthma. One large research focus involves establishing and studying a birth cohort from Northern Manhattan (www.CCCEH.org), determining the importance of environmental allergens, traffic-related pollutants, and phthalate exposure to the onset of allergies, asthma, and Th2 immune responses. A major emphasis is on the role of prenatal and early postnatal exposure on later pediatric and adolescent asthma risk. Additional areas of research include identifying novel genetic by environment interactions important to the onset of asthma. She also has established several mouse models examining the importance of prenatal and postnatal environmental exposures on asthma risk. More recent initiatives have been to build a program in environmental epigenetics and asthma by studying DNA methylation in cell, mouse and human systems. Recent work on antigen-specific immune responses to influenza vaccine in utero was cited by the journals Nature and Science on their websites.

Education and Training

Harvard University: A.B., Magna Cum Laude, 1982-1986
Medical School:
New York University School of Medicine: M.D., 1986-1990
NewYork-Prebyterian Hospital/Columbia University Medical Center, 1990-1993
NewYork-Prebyterian Hospital/Columbia University Medical Center, 1990-1993
Pulmonary and Critical Care Medicine, NewYork-Prebyterian Hospital/Columbia University Medical Center, 1993-1997;
Allergy and Immunology, NewYork-Prebyterian Hospital/Columbia University Medical Center, 1997-1999

Selected Honors and Awards

  • Harvard College Dean’s List
  • 1985 Collegiate National Rowing Championship, second place
  • 1986 Thomas T. Hoopes Prize for excellent senior honors thesis
  • 1986 Faculty Prize for distinguished senior honors thesis in psychobiology
  • 1987-1988 President of NYU Chapter of American Medical Student Association
  • 1990 Eve Flechner Award in Internal Medicine
  • 1999 Florence and Herbert Irving Clinical Research Career Award
  • 2007 AAAAI Clinical Fellowship Award to Allergy and Immunology Training Program at Columbia to support training of Dr. Kathleen Donohue
  • 2011-12 US News and World Report Top Doctor (pulmonologist)


Other Experience and Professional Membership

Director, Asthma Project, Columbia Center for Children;s Environmental Health
Fellow, American Academy of Allergy, Asthma and Immunology
Editorial Board of Clinical Medicine: Respiratory and Pulmonary Medicine
Director of Allergy, New York Presbyterian Hospital
Associate Director, Lead Physician Scientist, P50 Disease Investigation through Specialized Clinically-Oriented Ventures in Environment Research
Editorial Board of the Open Allergy Journal
Co-Deputy Director, Columbia Center for Children's Environmental Health
Co-Investigaror/Lab Supervisor for ICAC (Inner City Asthma Consortium) Ureca study
Editorial Board of the Journal of Allergy and Clinical Immunology, Impact factor 11.003


For appointments: 

622 West 168th Street, 8 Center
New York, NY 10032

P: (212) 305-0631
F: (212) 305-2277


  • Allergy & Immunology
  • Critical Care Medicine
  • Pulmonary Disease Medicine

Clinical Expertise

  • Asthma
  • Allergy
  • Anaphylaxis
  • Clinical Immunology

Clinical Centers

Board Certifications

  • Internal Medicine, Diplomate, 1993; 2002
  • Pulmonary Disease, Diplomate, 1996; 2005
  • Critical Care Medicine, Diplomate, 1997; 2006
  • Allergy and Immunology, Diplomate, 1999; 2009


Contact Information: 

Columbia University
College of Physicians & Surgeons
Miller Laboratory
630 W. 168th Street
P&S 8-430
New York, NY, 10032

Academic Office
P: (212) 305-7759
F: (212) 305-2277

P: (212) 342-1671

Email: rlm14@columbia.edu

Research Interests

  • Environmental epigenetics and asthma, allergy
  • Air pollution exposure and asthma
  • Chemical (phthalates, pesticides, bisphenol A) exposure and asthma

Selected Funding

  • 2R01ES13163-6A1
  • 5P01ES09600/RD-83214101
  • P50ES015905
  • 1R01 ES020424
  • RO1ES020425
  • RO1 ES020926
  • R21 AI101296

Selected Publications

  1. Rastogi, D., Chaodong Wang, Xia Mao, Cynthia Lendor, Paul B. Rothman, Rachel L. Miller. Antigen-specific immune responses to influenza vaccine in utero, Journal of Clinical Investigation, 117 (6):1637-46, 2007.
  2. Liu, Jinming, Manisha Ballaney, Umaima Al-alem, Chunli Quan, Ximei Jin, Frederica Perera, Lung-Chi Chen, Rachel L. Miller. Combined inhaled diesel exhaust particles and allergen exposure alter methylation of T helper genes and IgE production in vivo, Toxicological Sciences, 102 (1), 76-81, 2008
  3. Donohue, Kathleen M., Umaima Al-alem, Matthew S. Perzanowski, Ginger L. Chew, Alina Johnson, Adnan Divjan, Elizabeth A. Kelvin, Lori A. Hoepner, Frederica P. Perera, Rachel L. Miller. Anti-cockroach, mouse IgE is associated with early wheeze and atopy in an inner-city birth cohort, Journal of Allergy and Clinical Immunology, 122(5):914-20, 2008.
  4. Miller, Rachel L and Shuk-mei Ho Environmental epigenetics and asthma: Current concepts and call for studies, American Journal of Respiratory and Critical Care Medicine, 177:567-573, 2008.
  5. Miller, Rachel L. Prenatal maternal diet and asthma risk. The Journal of Clinical Investigation, 118(10):3265-3268, 2008.
  6. Perera F, W-Y Tang W-Y, JB Herbstman, DT Tang, L Levin, RL Miller and S-M Ho. Relation of DNA methylaton status of a 5’ island of ACSL3 to transplacental exposure to airborne polycyclic aromatic hydrocarbons and childhood asthma. PlosOne, 4(2) February 2009.
  7. Patel, Molini M., Lori Hoepner, Robin Garfinkel, Steven Chillrud, Andria Reyes, Frederica Perera, Rachel L. Miller. Ambient metals and elemental carbon in fine particulate matter predict wheeze and cough in very young urban children, American Journal of Respiratory and Critical Care Medicine, 180 (11):1107-1113. 2009.
  8. Marilyn Reyes , Matthew S. Perzanowski, Robin M. Whyatt, Elizabeth A. Kelvin, Andrew G. Rundle, Diurka Diaz, Beatriz Plaza, Lori Hoepner, Frederica P. Perera, Virginia Rauh, Rachel L. Miller. Maternal demoralization is associated with childhood wheeze, but not IgE, at age five years in an inner-city cohort, Annals of Allergy, Asthma and Immunology, 107 (1): 42-49, 2011.
  9. Phillip Factor, Alexander Akhmedov, Jake MacDonald, Anna Xu, Jie Wu, Trisha Das, Raymond Panettieri, Frederica Perera, and Rachel L. Miller. Polycyclic aromatic hydrocarbons impair b2AR function in airway epithelial and smooth muscle cells, The American Journal of Respiratory Cell and Molecular Biology, 45: 1045-1049, 2011.
  10. Unnur S. Bjornsdottir, Stephen T. Holgate, Padmalatha S. Reddy…Rachel L. Miller…et. al. Pathways activated during human asthma exacerbation as revealed by gene expression patterns in blood. PlosOne. 6(7): e21902, 2011.
  11. Molini M. Patel, James W. Quinn, Kyung Hwa Jung, Lori Hoepner, Diurka Diaz, Matthew Perzanowski, Andrew Rundle, Patrick L. Kinney, Frederica P. Perera, and Rachel L. Miller. Traffic density and point sources of air pollution associated with asthma and allergy from birth to age 5 years among New York City children, Environmental Research, 111(8): 1222-29, 2011.
  12. Rachel L. Miller and Cara L. Agerstrand. Targeting indoor air pollution: Interpreting the RESPIRE trial, The Lancet, 378:1682-83, 2011.
  13. Allan C. Just, Robin M. Whyatt, Matthew S. Perzanowski, Antonia M. Calafat, Frederica P. Perera, Inge F. Goldstein, Qixuan Chen, Andrew G. Rundle, Rachel L. Miller. Prenatal exposure to butylbenzyl phthalate and early eczema in an urban cohort, Environmental Health Perspectives, 120 (10):1475-80, 2012.
  14. Miller, Rachel L. Asthma epigenetics: Emergence of a new paradigm? In: Michels KB (ed). Epigenetic Epidemiology.New York, Springer Publishing, Chapt 16: 307-320, 2012.
  15. Matthew S. Perzanowski, Ginger L. Chew, Adnan Divjan, Kyung Hwa Jung, Robert Ridder, Deliang Tang, Diurka Diaz, Inge F. Goldstein, Patrick L. Kinney, Andrew G. Rundle, David E. Camann, Frederica P. Perera, Rachel L. Miller. Early-life cockroach allergen and polycyclic aromatic hydrocarbon exposures predict cockroach sensitization among inner-city children. J. Allergy and Clinical Immunology, 2013, in press

*Please see CV for complete list of publications