Rachel L. Miller, M.D.

Professor of Medicine (In Pediatrics) and Environmental Health Sciences
Director, Division of Pediatric Allergy, Immunology and Rheumatology
Director, Allergy and Immunology Fellowship Program
 

Bio

Dr. Miller is board certified in Pulmonary Disease and Allergy and Immunology. She has appointments in 3 departments in 2 Columbia schools and is the Director of the Allergy and Immunology Fellowship program and Director of Adult Allergy. She was named as top pulmonologist in the 2011-2013 US News and World Report, designated as a Fellow at the American Academy of Allergy Asthma and Immunology, and honored as a Samberg Scholar in Children's Health. Her clinical office specializes in the treatment of asthma and allergies.

Her research concentrates on the mechanisms for the onset of asthma. One large research focus involves establishing and studying a birth cohort from Northern Manhattan (www.CCCEH.org), determining the importance of environmental allergens, traffic-related pollutants, and phthalate and bisphenol A exposure to the onset of allergies, asthma, and Th2 immune responses. A major emphasis is on the role of prenatal and early postnatal exposure on later pediatric and adolescent asthma risk. Additional areas of research include identifying novel genetic by environment interactions important to the onset of asthma. She also has established several mouse models examining the importance of prenatal and postnatal environmental exposures on asthma risk. More recent initiatives have been to build a program in environmental epigenetics and asthma by studying DNA methylation in cell, mouse and human systems for which she is now internationally recognized.

Education and Training

Undergraduate:
Harvard University: A.B., Magna Cum Laude, 1982-1986
Medical School:
New York University School of Medicine: M.D., 1986-1990
Internship:
NewYork-Prebyterian Hospital/Columbia University Medical Center, 1990-1993
Residency:
NewYork-Prebyterian Hospital/Columbia University Medical Center, 1990-1993
Fellowship(s):
Pulmonary and Critical Care Medicine, NewYork-Prebyterian Hospital/Columbia University Medical Center, 1993-1997;
Allergy and Immunology, NewYork-Prebyterian Hospital/Columbia University Medical Center, 1997-1999

Selected Honors and Awards

  • Harvard College Dean’s List
  • 1985 Collegiate National Rowing Championship, second place
  • 1986 Thomas T. Hoopes Prize for excellent senior honors thesis
  • 1986 Faculty Prize for distinguished senior honors thesis in psychobiology
  • 1987-1988 President of NYU Chapter of American Medical Student Association
  • 1990 Eve Flechner Award in Internal Medicine
  • 1999 Florence and Herbert Irving Clinical Research Career Award
  • 2007 AAAAI Clinical Fellowship Award to Allergy and Immunology Training Program at Columbia to support training of Dr. Kathleen Donohue
  • 2011-13 US News and World Report Top Doctor (pulmonologist)
  • 2015 Samberg Scholar in Children’s Health
  • 2017 Thomas A. Neff Lecturer at the Thomas L. Petty Aspen Lung Conference, 60th Annual Meeting, "Environment and Global Lung Health: Exposure, Susceptibility and Intervention" 

Other Experience and Professional Membership

  • Fellow, American Academy of Allergy, Asthma and Immunology, 6/05-present
  • Director of Allergy, New York Presbyterian Hospital, 7/1/07-present
  • Associate Director, Lead Physician Scientist, P50 Disease Investigation through Specialized Clinically-Oriented Ventures in Environment Research, 7/1/07-2013.
  • Co-Deputy Director, Columbia Center for Children's Environmental Health, 1/1/09-present
  • Editorial Board of the Journal of Allergy and Clinical Immunology 3/12-3/17. Impact Factor 13.08
  • Section Editor, Allergies and the Environment, Current Allergy and Asthma Reports, volume 13, 2014.
  • Associate Editor, Clinical Epigenetics, Allergy and Immunology section, 9/14-present
  • AAAAI grant review committee, Vice Chair, 1/1/16-present
  • Member, Herbert Irving Comprehensive Cancer Center, Cancer Epidemiology Program, 3/5/16-present
  • Associate Director, Columbia University Medical Center and NewYork-Presbyterian/Morgan Stanley Children’s Hospital Food Allergy Research and Education Clinical Network, 7/16-present

Clinical

For appointments: 

622 West 168th Street, 8 Center
New York, NY 10032

P: (212) 305-1544
F: (212) 305-2277

Specialties

  • Allergy & Immunology
  • Pulmonary Disease Medicine

Clinical Expertise

  • Asthma
  • Allergy
  • Anaphylaxis
  • Clinical Immunology

Clinical Centers

Board Certifications

  • Internal Medicine, Diplomate, 1993; 2002
  • Pulmonary Disease, Diplomate, 1996; 2005; 2017
  • Critical Care Medicine, Diplomate, 1997; 2006
  • Allergy and Immunology, Diplomate, 1999; 2009

Research

Contact Information: 

Columbia University
College of Physicians & Surgeons
Miller Laboratory
630 W. 168th Street
P&S 8-430
New York, NY, 10032

Academic Office
P: (212) 305-7759
F: (212) 305-2277

Laboratory
P: (212) 342-1671

Email: rlm14@columbia.edu

Research Interests

  • Environmental epigenetics and asthma, allergy
  • Air pollution exposure and asthma
  • Chemical (phthalates, pesticides, bisphenol A) exposure and asthma

Selected Funding

  • 2 P50 ES09600
  • 2R01ES13163-06A1
  • 1R01HL118612A1
  • 1U01ES026122
  • R21 ES024718
  • 1UG3OD023282

Selected Publications (from total list of 137 publications)

  1. Rastogi, D., Chaodong Wang, Xia Mao, Cynthia Lendor, Paul B. Rothman, Rachel L. Miller. Antigen-specific immune responses to influenza vaccine in utero, Journal of Clinical Investigation, 117 (6):1637-46, 2007.
  2. Donohue, Kathleen M., Umaima Al-alem, Matthew S. Perzanowski, Ginger L. Chew, Alina Johnson, Adnan Divjan, Elizabeth A. Kelvin, Lori A. Hoepner, Frederica P. Perera, Rachel L. Miller. Anti-cockroach, mouse IgE is associated with early wheeze and atopy in an inner-city birth cohort, Journal of Allergy and Clinical Immunology, 122(5):914-20, 2008.
  3. Miller, Rachel L and Shuk-mei Ho Environmental epigenetics and asthma: Current concepts and call for studies, American Journal of Respiratory and Critical Care Medicine, 177:567-573, 2008.
  4. Miller, Rachel L. Prenatal maternal diet and asthma risk. The Journal of Clinical Investigation, 118(10):3265-3268, 2008.
  5. Patel, Molini M., Lori Hoepner, Robin Garfinkel, Steven Chillrud, Andria Reyes, Frederica Perera, Rachel L. Miller. Ambient metals and elemental carbon in fine particulate matter predict wheeze and cough in very young urban children, American Journal of Respiratory and Critical Care Medicine, 180 (11):1107-1113. 2009.
  6. Rachel L. Miller and Cara L. Agerstrand. Targeting indoor air pollution: Interpreting the RESPIRE trial, The Lancet, 378:1682-83, 2011.
  7. Allan C. Just, Robin M. Whyatt, Matthew S. Perzanowski, Antonia M. Calafat, Frederica P. Perera, Inge F. Goldstein, Qixuan Chen, Andrew G. Rundle, Rachel L. Miller. Prenatal exposure to butylbenzyl phthalate and early eczema in an urban cohort, Environmental Health Perspectives, 120 (10):1475-80, 2012.
  8. Matthew S. Perzanowski, Ginger L. Chew, Adnan Divjan, Kyung Hwa Jung, Robert Ridder, Deliang Tang, Diurka Diaz, Inge F. Goldstein, Patrick L. Kinney, Andrew G. Rundle, David E. Camann, Frederica P. Perera, Rachel L. Miller. Early-life cockroach allergen and polycyclic aromatic hydrocarbon exposures predict cockroach sensitization among inner-city children. J. Allergy and Clinical Immunology, 131(3):886-893, 2013.
  9. Kyung Hwa Jung, Matthew Perzanowski, Andrew Rundle, Kathleen Moors, Beizhan Yan, Steven N. Chillrud, Robin Whyatt, David Camann, Frederica P. Perera, Rachel L. Miller. Polycyclic aromatic hydrocarbon exposure, obesity and childhood asthma in an urban cohort, Environmental Research, 128:35-41, 2014.
  10. Robin M. Whyatt, Matthew S. Perzanowski, Allan C. Just, Andrew G. Rundle, Kathleen M. Donohue, Antonia M. Calafat, Lori Hoepner, Frederica P. Perera, Rachel L. Miller. Asthma in inner-city children at 5-11 years of age and prenatal exposure to phthalates: The Columbia Center for Children’s Environmental Health Cohort, Environmental Health Perspectives, 122:1141-1146, 2014.
  11. Zhonghai Yan, Hanjie Zhang, Christina Maher, Emilio Arteaga-Solis, Frances A. Champagne, Licheng Wu, Jacob D. McDonald, Beizhan Yan, Gary J. Schwartz, Rachel L. Miller. Prenatal polycyclic aromatic hydrocarbon, adiposity, peroxisome proliferator-activated receptor (PPAR) γ methylation in offspring, grand-offspring mice, PLOSOne, 9(10):e110706, 2014.
  12. Kyung Hwa Jung, Stephanie Lovinsky-Desir, Matthew Perzanowski, Xinhua Liu, Christina Maher, Eric Gil, David Torrone, Andreas Sjodin, Zheng Li, Frederica P. Perera, Rachel L. Miller. Repeatedly high polycyclic aromatic hydrocarbon exposure and cockroach sensitization among inner-city children, Environmental Research, 140: 649-56, 2015, PMCID: PMC4492866.
  13. Rachel L. Miller. Environmental medical epigenetics: A review of epigenetically-induced medical risks generated from exposures in our air, food, and personal products. Medical Epigenetics. Trygve Tollesfsbol editor, Elsevier, chapter 7, p. 103-127, 2016.
  14. Elizabeth C. Matsui, Matthew Perzanowski, Roger D. Peng, Robert A. Wise, Susan Balcer-Whaley, Michelle Newman, Amparito Cunningham, Adnan Divjan, Mary E. Bollinger, Shuyan Zhai,, Ginger Chew, Rachel L. Miller, Wanda Phipatanakul. Effect of an integrated pest management intervention on asthma symptoms among mouse-sensitized children and adolescents with asthma: A randomized clinical trial, JAMA, 317(10):1027-36, 2017.
  15. Kyung Hwa Jung, David Torrone, Stephanie Lovinsky-Desir, Matthew Perzanowski, Joshua Bautista, Jacqueline R. Jezioro, Lori Hoepner, Jamie Ross, Frederica P. Perera, Steven N. Chillrud, Rachel L. Miller. Short-term exposure to PM2.5 and vanadium and changes in asthma gene DNA methylation and lung function decrements among urban children. Respiratory Research, 18(1):63, 2017. PMCID: PMC5397738.
  16. Kyung Hwa Jung, Stephanie Lovinsky-Desir, Beizhan Yan, David Torrone, Jennifer Lawrence, Jacqueline R. Jezioro, Matthew Perzanowski, Frederica P. Perera, Steven N. Chillrud, Rachel L. Miller. Effect of personal exposure to black carbon on changes in allergic asthma gene methylation measured five days later in urban children: Importance of allergic sensitization. Clinical Epigenetics, 9:61, 2017. PMCID: PMC5457544.

View Dr. Miller's list of publications