Kristin Burkart, M.D., M.Sc.

Assistant Professor of Clinical Medicine
Program Director, Pulmonary & Critical Care Fellowship
Director, Chest Clinic

Bio
Clinical
Research

Bio

Dr. Burkart is an Assistant Professor of Clinical Medicine at Columbia University and the Program Director of the Pulmonary and Critical Care Medicine Fellowship. She is also the Director of the Chest Clinic. Dr. Burkart graduated AOA from Albany Medical College, completed her residency and chief residency at the University of Colorado Health Sciences Center and completed her fellowship in Pulmonary and Critical Care Medicine at Boston University School of Medicine. She has a Master of Science in Epidemiology from Boston University School of Public Health. Dr. Burkart attends in the MICU, on the pulmonary consultative service, the ICU consultative service and the chronic ventilator management service. She is committed to providing quality palliative care at end-of-life and is an active member of the Ethics Committee. Dr. Burkart is dedicated to providing high-quality care for the diverse, under-served patient population cared for in the Chest Clinic.

Dr. Burkart’s research focuses on the genetics of COPD and emphysema. She is involved in two genome-wide association studies of lung function among European-American and African-American participants in a large consortium of NHLBI cohorts. Additional areas of interest include the epidemiology of COPD/emphysema, and pulmonary vascular disease associated with COPD/emphysema. Dr. Burkart works with Graham Barr on the Multi-Ethnic Study of Atherosclerosis (MESA) investigating associations between candidate genes related to vascular endothelial pathways and COPD/emphysema as well as genetic and epidemiologic investigations of lung function and CT percent emphysema in MESA.

Education and Training

Undergraduate:: Bachelor of Science in Biology, Villanova University, 1988-1992
Graduate School:: Master in Science in Epidemiology, Boston University School of Public Health, 2003-2006
Medical School:: Albany Medical College, 1992-1996
Internship:: Internal Medicine, University of Colorado Health Sciences, 1996-1997
Residency:: Internal Medicine, University of Colorado Health Sciences, 1996-1999
Chief Residency:: Internal Medicine, University of Colorado Health Sciences Center, 1999-2000
Fellowship(s):: Clinical Fellow, Pulmonary and Critical Care, Boston University School of Medicine, 2001-2004; Research Fellow, Pulmonary Medicine, Boston University School of Medicine, 2004-2005

Selected Honors and Awards

1990 Phi Sigma, Biology Honor Society
1991 Alpha Epsilon Delta, Pre-Med Honor Society
1992 Cum Laude, Villanova University
1994 Hematology Summer Clinical & Research Award
1995 Alpha Omega Alpha
1996 Fredrick H. Hesser Prize for clinical excellence in Neurology, Albany Medical College
1996 Richard A. Barnett Award for clinical excellence in Internal Medicine, Albany Medical College
2008 AAMC Professional Development Seminar for Early Career Women Faculty Travel Award from College of Physicians & Surgeons of Columbia University
2011 Fellow American College of Chest Physicians

Clinical

For appointments:

To initate a transfer request, physicians should call 1-800-NYP-STAT which is available 24 hours a day, 7 days a week.

Specialties

Pulmonary Disease Medicine
Critical Care Medicine
Medical Ethics

Clinical Expertise

Respiratory failure / acute respiratory Distress syndrome
ECMO-refractory hypoxemic respiratory failure
ECMO-PH crisis/Right ventricular failure
Sepsis
Critical illness
General pulmonary medicine
Medical ethics & palliative care
COPD/emphysema

Clinical Centers

Board Certifications

Internal Medicine Diplomate, 2009
Pulmonary Disease Diplomate, 2003
Critical Care Medicine Diplomate, 2004

Research

Research Interests

Genetics of COPD & emphysema
Pulmonary vascular disease associated with COPD & emphysema
ECMO for hypercapneic respiratory failure
Outcomes in patients on ECMO for hypoxemic respiratory failure

Selected Publications

S Nowbar, KM Burkart, R Gonzales, A Fedorowicz, W Gozansky, J Gaudio, M Taylor, C Zwillich. Obesity-associated hypoventilation in hospitalized patients: prevalence, effects, and outcome. Am J Med. 116 (1):1-7; 2004
KM Burkart, S Barton, J Holloway, I Yang, J Cakebread, W Cruikshank, F Little, MD, Xi Jin, L Farrer, J Clough, Tm Keith, S Holgate, D Center, G O’Connor. Association of asthma with a functional promoter polymorphism in the Interleukin-16 gene. Journal of Allergy & Clinical Immunology.117(1):86-91, 2006
EK Silverman, J Vestbo, A Agusti, W Anderson, PS Bakke, KC Barnes, RG Barr, ER Bleecker, HM Boezen, KM Burkart, BR Celli, MH Cho, WOC Cookson, T Croxton, D Daley, DL DeMeo, W Gan, J Garcia-Aymerich, P Hall, NN Hansel, CP Hersh, N Kalsheker, J P Kiley, WJ Kim, D Lambrechts, S Lee, AA Litonjua, DA Lomas, SJ London, M Nishimura, BG Nørdestgaard, C O’Donnell, DS Postma, MA Puhan, Y Tesfaigzi, MD Tobin, C Vogelmeier, JB Wilk, E Wouters, RP Young, L Ziegler-Heitbrock, Wi MacNee, JD Crapo. Opportunities and Challenges in Genetics of COPD 2010: An International COPD Genetics Conference Report. Journal of Chronic Obstructive Pulmonary Disease, 8:121-135; 2011.
Hancock DB*, Soler Artigas M*, Gharib SA*, Henry A*, Manichaikul A*, Ramasamy A*, Loth DW*, Imboden M, Koch B, McArdle WL, Smith AV, Smolonska J, Sood A, Tang W, Wilk JB, Zhai G, Zhao JH, Aschard H, Burkart KM, Curjuric I, Eijgelsheim M, Elliott P, Gu X, Harris TB, Janson C, Homuth G, Hysi PG, Liu JZ, Loehr LR, Lohman K, Loos RJF, Manning AK, Marciante KD, Obeidat M, Postma DS, Aldrich MC, Brusselle GG, Chen T-H, Eiriksdottir G, Franceschini N, Heinrich J, Rotter JI, Wijmenga C, Williams OD, Bentley AR, Hofman A, Laurie CC, Lumley T, Morrison AC, Joubert BR, Rivadeneira F, Couper DJ, Kritchevsky SB, Liu Y, Wjst M, Wain LV, Vonk JM, Uitterlinden AG, Rochat T, Rich SS, Psaty BM, O’Connor GT, North KE, Mirel DB, Meibohm B, Launer LJ, Khaw K-T, Hartikainen A-L, Hammond CJ, Gläser S, Marchini J, Kraft P, Wareham NJ, Völzke H, Stricker BHC, Spector TD, Probst-Hensch NM, Jarvis D, Jarvelin M-R, Heckbert SR, Gudnason V, Boezen HM, Barr RG, Cassano PA†, Strachan DP†, Fornage M†, Hall IP†, Dupuis J†, Tobin MD†, and London SJ† (2012). Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. PLoS Genetics, 8(12): e1003098 2012. *These authors contributed equally to this work. †These authors jointly directed the work
Oelsner, E., Pottinger, T., Burkart, KM., Allison, M., Buxbaum, S., Hansel, N., Kumar, R., Larkin, E., Lange, L., Loehr, L., London, S., O'Connor, G., Papanicolaou, G., Petrini, M., Rabinowitz, D., Raghavan, S., Redline, S., Thyagaran, B., Tracy, R., Wilk, J., White, W., Rich, S. & Barr R.G.. Adhesion molecules, endothelin-1 and lung function in seven population-based cohorts: the Candidate Gene Association Resource (CARe). Biomarkers. (ID: 762805 DOI:10.3109/1354750X.2012.762805)
KM Burkart, J Ma, C Hedrick, E Hoffman, R Jiang, J Mychaleckyj, L Raffel, S Rich, R G Barr. Association of lung function with polymorphisms of candidate genes in a vascular endothelial cell pathway in a multiethnic population. The MESA-Lung Study. Am. J. Respir. Crit. Care Med. 2009;179:A3003
KM Burkart, F Ahmed, K Watson, E Hoffman, R. G Barr. Association between High Density Lipoproteins (HDL) Cholesterol and CT Percent Emphysema. The Multi-Ethnic Study of Atherosclerosis (MESA) Lung Study. Am. J. Respir. Crit. Care Med.2010;181 A2878
KM Burkart, J Wilk, P Enright, F Ahmed, N Hansel, D Haynes, S Heckbert, L Loehr, S London, H Lyon, G O’Connor, E Oelsner, M Petrini, S Redline, L Smith, W White, S Rich, RG Barr. Candidate-Wide Association Study of Lung Function among European-and African-Americans in 8 Population-Based Cohorts. The Candidate-gene Association Resource (CARe). European Respiratory Society 2010
KM Burkart, M Aldrich, JWilk, R Powel, S Buxbaum, P Enright, N Hansel, D Haynes, S Heckbert, L Loehr, S London, H Lyon, A Manichaiku, M Petrini, S Redline, L Smith, W White, S Rich, RG Barr. Genome-Wide Association Study (GWAS) Of Lung Function Among African-Americans In 5 National Heart, Lung, and Blood Institute (NHLBI) Cohorts. The Candidate-gene Association Resource (CARe). Am. J. Respir. Crit. Care Med.2011;183:A1752
Powell RE, Manichaikul A, Burkart KM, Mychaleckyj J, Raffel LJ, Rich SS, Barr RG. A genome-wide association study to assess loci associated with lung function among Hispanic and Asian Americans: The MESA Lung SHARe Study (poster). Am. J. Respir. Crit. Care Med.2011;183:A1756
JB Wilk, NG Shrine, LR Loehr, JHZhao, A Manichaikul, LM Lopez, AV Smith, SR Heckbert, J Smolonska, W Tang, DW Loth, I Curjuric, J Hui, MH Cho, JC Latourelle, AP Henry, M Aldrich, P Bakke, TH. Beaty, AR. Bentley, IB Borecki, GG Brusselle, KM Burkart, T Chen, D Couper, JD Crapo, G Davies, J Dupuis, N Franceschini, A Gulsvik, DB Hancock, TB. Harris, A Hofman, M Imboden, AL James, K Khaw, L Lahousse, LJ Launer, A Litonjua, Y Liu, KK Lohman, DA Lomas, T Lumley, KD Marciante, WL McArdle, B Meibohm, AC Morrison, AW Musk, RiH Myers, KE North, DS Postma, BM Psaty, SS Rich, F Rivadeneira, T Rochat, JI Rotter, M Soler Artigas, JM. Starr, AG Uitterlinden, NJ Wareham, C Wijmenga, P Zanen, MA Province, EK. Silverman, IJ Deary LJ Palmer, PA Cassano, V Gudnason, RG Barr, RJ Loos, DP Strachan, SJ London, H Boezen, N Probst-Hensch, SA Gharib, I.P Hall, GT O’Connor, MD Tobin, BH Stricker. Genome wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction. American Journal Respiratory and Critical Care Medicine in press, July 26, 2012.

*Please see CV for complete list of publications

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