Jining Lu, PhD

Assistant Professor of Medical Sciences (in Medicine)

Bio

Dr. Jining Lu, Ph.D. Assistant Professor of Medicine. Dr. Lu has been a developmental biologist for about twenty years. His long-term research objective is to understand the gene regulatory networks required for proper lung development and homeostasis, focusing on the roles of small non-coding RNAs. After graduated from Zhejiang Jinhua Medical School, P.R. China, Dr. Lu worked as a clinical biochemist at College of Medicine Zhejiang University for four years. He then studied at Shanghai Second Medical University for a master degree in clinical biochemistry. He obtained a Ph.D. from Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Science in 1996, and then completed his postdoctoral training at the Laboratory of Cellular and Developmental Biology, NIDDK, NIH, USA. Dr. Lu joined the Pulmonary Center at Boston University School of Medicine and began his work focusing on lung development. Dr. Lu’s research has been supported by NIH funding and he has served on NHLBI study sections as ad hoc member. He has given invited lectures and serves as reviewer for multiple journals. Dr. Lu has won awards including the Prof. Mai Jieqian (The Chinese University of Hong Kong) Life Science Scholarship and Robert Dawson Evans Junior Faculty Merit Award, Boston University School of Medicine. Currently, Dr. Lu’s group is investigating microRNAs or components of microRNA pathway as critical posttranscriptional regulators in airway epithelial or lung mesenchymal cell differentiation during development or in response to injury or stress.

Education and Training

Undergraduate:
B.S., Zhejiang Jinhua Medical School, 1985
Medical School:
M.S., Shanghai Second Medical University, 1992
Graduate School:
D. Phil, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, 1996
Fellowship(s):
Postdoctoral fellow, The National Institute of Diabetes and Digestive and Kidney Diseases (NIH), University of Chicago Hospitals, Chicago, IL, 1996-2001

Selected Honors and Awards

  • 1995 Prof. Mai Jieqian (The Chinese University of Hong Kong) Life Science Scholarship
  • 2008 Robert Dawson Evans Junior Faculty Merit Award, Boston University School of Medicine
  • 2010 Boston University Ignition Award

Research

Contact Information: 

Columbia Center for Human Development-Lu Laboratory
650 West 168th Street
BB 8-810
New York, NY 10032

Laboratory
P: (212) 342-4416
E: jl4211@columbia.edu

Research Interests

  • miRNA-mediated posttranscriptional regulation in airway epithelial cell differentiation
  • miRNA components in the airway epithelial cells in response to stress or injury, such as RSV infection
  • miRNA in respiratory disorders, such as fibrosis
  • Developmental genomics of lung development

Selected Funding

  • MicroRNA Pathway in Proximal-Distal Differentiation during Mouse Lung Principal investigator of project 2: Jining Lu. National Heart, Lung, and Blood Institute P01( HL4749), 2008-2013
  • MicroRNA-mediated Gene Regulation in Lung Development Principal investigator: Jining Lu National Heart, Lung, and Blood Institute R01( HL081800), 2006-2011
  • MicroRNA-mediated Gene Regulation in Lung Development Principal investigator: Jining Lu National Heart, Lung, and Blood Institute R01( HL081800), 2006-2011

Selected Publications

  1. Lü J, Andrews J, Pauli D, Oliver B. Drosophila OVO zinc-finger protein regulates ovo and ovarian tumor target promoters. Dev Genes Evol. 1998 Jun; 208(4):213-22.
  2. Lü J, Oliver B. Developmentally regulated OVO transcription factors mediate enhancer/promoter compatibility in the Drosophila germline. Development 2001; 128: 1671-1686.
  3. Lü J, Qian J, Izvolsky KI, Cardoso WV (2004). Global analysis of genes differentially expressed in branching and non-branching regions of the mouse embryonic lung. Dev. Biol. 273, 418-435.
  4. Lü J, Izvolsky KI, Qian J, and Cardoso WV . Identification of FGF10 targets in the embryonic lung epithelium during bud morphogenesis. J Biol Chem. 2005 Feb 11;280(6):4834-41.
  5. Cardoso WV, Lü J. Regulation of early lung morphogenesis: questions, facts and controversies. Development. 2006 May;133(9):1611-24. review article.
  6. Lü J, Qian J, Keppler D, Cardoso WV. Cathespin H is an FGF10 Target Involved in BMP4 Degradation during Mouse Lung Branching Morphogenesis. J. Biol Chem 282:22176–22184, 2007.
  7. Schembri F, Sridhar S, Perdomo C, Gustafson AM, Zhang X, Ergun A, Lü J, Liu G, Zhang X, Bowers J, Vaziri C, Sensinger K, Collins JJ, Brody JS, Getts R, Lenburg ME, Spira A. MicroRNAs as modulators of smoking-induced gene expression changes in human airway epithelium. Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2319-24.
  8. Wu J, Qian J, Li C, Kwok L, Cheng F, Liu P, Perdomo C, Kotton D, Vaziri C, Anderlind C, Spira A, Cardoso WV, Lü J. miR-129 regulates cell proliferation by downregulating Cdk6 expression. Cell Cycle. 2010 May 15;9(9).
  9. Cushing L, Kuang PP, Qian J, Shao F, Wu J, Little F, Thannickal VJ, Cardoso WV, Lü J. miR-29 is a Major Regulator of Genes Associated with Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2010 Oct 22.
  10. Jiang Z, Yu N, Kuang P, Chen M, Martin G, Chui DHK, Wellington V. Cardoso, Ai X, Lü J. GW182-mediated microRNA function is required for the development of yolk sac endoderm. J Biol Chem. 2012 Feb 17;287(8):5979-87.
  11. Jiang Z, Yu N, Wellington V. Cardoso, Ai X, Lü J. miR-326 is downstream of SHH pathway with negative feedback activity in developing lung. Am J Respir Cell Mol Biol. 2014 Aug; 51(2):273-83.
  12. Cushing L, Costinean S, Xu W, Jiang Z, Madden L, Kuang P, Huang J, Weisman A, Hata A, Croce CM, Lü J. Disruption of miR-29 Leads to Aberrant Differentiation of Smooth Muscle Cells Selectively Associated with Distal Lung Vasculature. PLoS Genet. 2015 May 28.

View Dr. Lu's full list of publications from PubMed