Jeanine D'Armiento, M.D., Ph.D.

Associate Professor of Medicine
Associate Dean for Gender Equity and Career Development for CUMC

Bio

Education and Training

Undergraduate:
BA, Rutgers College, Rutgers University (Biochemistry - Honors), 1985
Graduate:
PhD, UMDNJ-Robert Wood Johnson Medical School, "Murine Analog of Emphysema in Transgenic Mice" (Sponsor - Richard Berg, Rutgers University), 1990
Medical School:
UMDNJ-Robert Wood Johnson Medical School, 1992
Internship:
Internal Medicine, Columbia Presbyterian Medical Center
Residency:
Internal Medicine, Columbia Presbyterian Medical Center
Fellowship(s):
Pulmonary and Critical Care, Columbia Presbyterian Medical Center

Honors and Awards

  • 1985 Henry Rutgers Scholar Honors
  • 1993 Research Award for Trainees, National Institutes of Health
  • 1996 Burroughs Welcome Career Award
  • 1997 Dewitt S. Goodman Fellowship
  • 2000 UMDNJ Distinguished Alumni Award
  • 2003 American Society of Clinical Investigation
  • 2007-2012 Established Investigator Award-American Heart Association

Clinical

For appointments: 

622 West 168th Street
PH-8 Center
New York, NY 10032

Herbert Irving Pavilion
161 Fort Washington Avenue, 3rd Floor Rm. 312
New York, NY 10032

P: (212) 305-3745

Specialties

  • Pulmonary Disease Medicine

Clinical Expertise

  • Lymphangioleiomyomatosis (LAM)
  • Pulmonary Disease Medicine

Research

Contact Information: 

D'Armiento Lab
630 W. 168th Street
P&S 9-449
New York, NY 10032
P: (212) 305-7757

Research Interests

  • Role of matrix metalloproteinases in tissue destruction during disease processes
  • Transgenic mouse models of emphysema, heart failure and arthritis
  • Role of HMGA2 in pathogenesis of Lymphangioleiomyomatosis

Funding

  • "Smoke Induced Airway Injury in COPD" NIH-R01 HL086936
  • "Inducible Macrophage Specific Gene Expression in Diseases" NIH-ARRA-Challenge Grant RC HL 100384
  • "Novel Mechanisms of MMP Induction in Vascular Smooth Muscle Cells" American Heart Association-Established Investigator Award

Selected Publications

  1. D’Armiento J, Dalal SS, Okada Y, Berg RA, Chada K. Collagenase expression in the lungs of transgenic mice causes pulmonary emphysema. Cell. 1992;71:955-61.
  2. Imai K, Dalal SS, Chen ES, Downey R, Schulman LL, Ginsburg M, D’Armiento J. Human collagenase (matrix metalloproteinase-1) expression in the lungs of patients with emphysema. American Journal of Respiratory and Critical Care Medicine. 2001;163(3 Pt 1):786-91.
  3. Lemaitre V, O’Byrne TK, Borczuk AC, Okada Y, Tall AR, D’Armiento J. ApoE knockout mice expressing human matrix metalloproteinase-1 in macrophages have less advanced atherosclerosis. The Journal of Clinical Investigation. 2001;107:1227-34.
  4. Mercer BA, Kolesnikova N, Sonett J, D’Armiento J. Extracellular regulated kinase/mitogen activated protein kinase is up-regulated in pulmonary emphysema and mediates matrix metalloproteinase-1 induction by cigarette smoke. The Journal of Biological Chemistry. 2004;279:17690-6.
  5. D’Armiento J, Imai K, Schiltz J, Kolesnekova N, Sternberg D, Benson K, Pardo A, Selman M, Smolarek T, Vundavalli M, Sonnet J, Szabolcs M, Chada K. Identification of the benign mesenchymal tumor gene HMGA2 in lymphangiomyomatosis. Cancer Research. 2007;67:1902-9.
  6. Foronjy R, Imai K, Shiomi T, Mercer B, Sklepkiewicz P, Thankachen J, Bodine P, D’Armiento J. The divergent roles of secreted frizzled related protein-1 (SFRP1) in lung morphogenesis and emphysema. The American Journal of Pathology. 2010;177:598-607.
  7. Elkington P, Shiomi T, Breen R, Nuttall RK, Ugarte-Gil CA, Walker NF, Saraiva L, Pedersen B, Mauri F, Lipman M, Edwards DR, Robertson BD, D’Armiento J, Friedland JS. MMP-1 drives immunopathology in human tuberculosis and transgenic mice. The Journal of Clinical Investigation. 2011;121:1827-33.
  8. Geraghty P, Dabo AJ, D’Armiento J. TLR4 protein contributes to cigarette smoke-induced matrix metalloproteinase-1 (MMP-1) expression in chronic obstructive pulmonary disease. The Journal of Biological Chemistry. 2011;286:30211-8.

*Please see CV for complete list of publications