Jaime L. Hook, M.D.

Assistant Professor of Medicine

Bio

Dr. Jaime Hook’s clinical and research career is focused on improving the lives of patients with severe lung diseases. She is an attending physician in the Lung Transplantation Program at the New York Presbyterian Hospital/Columbia University Medical Center, where she cares for patients with severe lung diseases before and after lung transplantation. Since lung infection is a major problem for all patients with lung disease, her research program is designed to understand lung infection mechanisms, particularly the host-pathogen interactions that determine severe lung infection and fatal acute lung injury. New understanding of these interactions is essential to developing new treatments, which is becoming critically important in this era of worsening bacterial resistance to antibiotics.

At all levels of training, Dr. Hook has been strongly committed to building a basic and translational research career in lung disease and lung biology. In medical school, she was awarded a Research Fellowship from the University of Wisconsin Institute for Clinical and Translational Research to carry out her research project. She continued her research training during her residency and clinical fellowship, forming a solid foundation in the clinical research of severe lung diseases and lung transplant candidate selection under the mentorship of Dr. David Lederer. She joined the Bhattacharya laboratory in 2013 as a T32 Research Fellow to gain training in the biology of lung infection and acute lung injury. Since then she has garnered a highly competitive 5-year research grant, numerous invited lectures and awards, and national attention for her work. Her ongoing projects use real-time optical imaging of live, intact mouse and human lungs to gain new understanding as to how influenza and Staphylococcus aureus cause lung injury. It is her hope that, by incorporating both basic and clinical approaches, her research will lead to new treatments for the fatal lung injury caused by severe lung infection.

Please refer to Dr. Hook’s CV and NIH Biosketch for further information.

Education and Training

Undergraduate:
B.S. in Molecular Biology, University of Wisconsin, Madison, WI, 2004
Medical School:
University of Wisconsin School of Medicine and Public Health (UWSMPH), Madison, WI, 2008
Internship:
Department of Medicine, New York University Medical Center, NY, NY, 2008-2009
Residency:
Department of Medicine, Columbia University Medical Center (CUMC), NY, NY, 2009-2011
Fellowships:
Research Fellowship, Institute for Clinical and Translational Research, UWSMPH, 2004
Clinical Fellowship, Pulmonary and Critical Care Medicine, CUMC, 2011-2014
Research Fellowship (T32 HL105323), Lung Biology Laboratory, Columbia University, 2013-2015

Honors and Awards

  • 2018 Jo Rae Wright Award in recognition of outstanding scientific achievement by a young investigator, Respiratory Cell and Molecular Biology (RCMB) Assembly, American Thoracic Society (ATS)
  • 2018 Science and Innovation Center Abstract Award, RCMB Assembly, ATS
  • 2016 Abstract Scholarship, RCMB Assembly, ATS
  • 2012, 2014, 2015 Abstract and Travel Awards, ATS and FASEB
  • 2010 Arnold P. Gold Foundation Award for Humanism and Excellence in Teaching
  • 2008 Alpha Omega Alpha
  • 2008 Gold Humanism Honor Society Membership
  • 2007 Wisconsin Medical Society Foundation Presidential Scholar Award for Medical Leadership
  • 2006 Wisconsin Medical Alumni Association Scholarship for Leadership
  • 2004 Phi Beta Kappa

Other Experience and Professional Membership

  • 2018 Program Committee Member, RCMB Assembly, ATS
  • 2018 Co-Chair, Gordon Research Seminar on the Biology of Acute Respiratory Infection
  • 2016 Invited Junior Faculty Panelist, CUMC Academic and Research Career Guidance Seminar for Department of Medicine Fellows
  • 2014, 2016, 2018 Speaker, FASEB and Gordon Conferences
  • 2012, 2014, 2016, 2018 Speaker, ATS Conference Mini Symposia
  • 2005-2006 Member, Wisconsin Medical Society Board of Directors
  • 2005-2006 President, Medical Student Association, UWSMPH

Clinical

For appointments: 

Lung Transplantation Program
Columbia University Medical Center
622 West 168th Street, PH-14 Room 104
New York, NY 10032
Phone: 212-305-7771| Fax: 212-342-5382

Specialties

  • Pulmonary Disease Medicine
  • Critical Care Medicine
  • Lung Transplantation

Clinical Expertise

  • Advanced Lung Disease
  • Lung Transplantation

Board Certifications

  • Critical Care Medicine Diplomate, 2014
  • Pulmonary Disease Diplomate, 2013
  • Internal Medicine Diplomate, 2011

Research

Contact Information: 

Lung Biology Laboratory
Division of Pulmonary, Allergy, and Critical Care Medicine
Columbia University Medical Center

630 West 168th Street, BB 8 Room 812
New York, NY 10032
Lab manager, Rashmi Patel: rnp2105@cumc.columbia.edu
Phone: 212-305-7310

Lung Transplantation Program
Division of Pulmonary, Allergy, and Critical Care Medicine
Columbia University Medical Center

622 West 168th Street, PH-14 Room 104
New York, NY 10032
Admin assistant, Maylin Rincon: mer2159@cumc.columbia.edu
Phone: 212-305-7771

Research Interests

  • Host-pathogen interactions in lung infection
  • Mechanisms of acute lung injury, alveolar barrier deterioration, and alveolar repair
  • Real-time optical imaging of live, intact mouse and human lungs
  • Use of genetic indicators based on fluorescence resonance energy transfer (FRET) in live lung imaging
  • Clinical prognostication in patients with idiopathic pulmonary fibrosis
  • Candidate selection for lung transplantation

Funding

  • Columbia University Irving Institute/Clinical Trials Office Pilot Award: Novel mechanisms of post-influenza staphylococcal lung injury (PI:Hook; 7/1/18-6/30/19)
  • AHA Fellow-to-Faculty Transition Award: Pulmonary microvascular responses to methicillin-resistant Staphylococcus aureus lung infection (PI: Hook; 7/1/16-6/30/21)
  • Stony Wold-Herbert Fund Research Training Fellowship and Competitive Renewal (PI: Hook; completed)
  • NHLBI T32 HL105323: Columbia Training Program in Lung Science (PI: Bhattacharya; Fellow: Hook; completed)
  • Research Fellowship, University of Wisconsin Institute for Clinical and Translational Research: Self-rated health as a predictor of future functioning in older adults after a diagnosis of cancer (PI: Hook; completed)

Selected Publications

Hook JL, Islam MN, Parker D, Prince AS, Bhattacharya S, Bhattacharya J. Disruption of staphylococcal aggregation protects against lethal lung injury. J Clin Invest. 2018;128(3):1074-86. PMID 29431734

Benvenuto LJ, Anderson DR, Kim HP, Hook JL, Shah L, Robbins HY, D’Ovidio F, Bacchetta M, Sonett JR, Arcasoy SM. Geographic disparities in donor lung supply and lung transplant waitlist outcomes: a cohort study. Am J Transplant. 2017. In press. PMID 29266733.

Hook JL, Arcasoy SM, Zemmel D, Bartels MN, Kawut SM, Lederer DJ. Titrated oxygen requirement and prognostication in idiopathic pulmonary fibrosis. Eur Respir J. 2012;39(2):359-65. PMID 21885386

Hook JL, Lederer DJ. Socioeconomic barriers to lung transplantation: balancing access and equity. Am J Respir Crit Care Med. 2012;186(10): 937-9. PMID 23155209

Hook JL, Lederer DJ. Selecting lung transplant candidates: where do current guidelines fall short? Expert Rev Respir Med. 2012;6(1):51-61. PMID 22283579

View Dr. Hook's full list of publications from PubMed