Jaime L. Hook, M.D.

Assistant Professor of Medicine

Bio

Dr. Hook’s clinical and research career is focused on improving the lives of patients with severe lung diseases. She is an attending physician in the Lung Transplantation Program at the New York Presbyterian Hospital/Columbia University Medical Center, where she cares for patients with severe lung diseases before and after lung transplantation. Since lung infection is a major problem for all patients with lung disease, her research program is designed to understand lung infection mechanisms, particularly the host-pathogen interactions that determine severe lung infection and fatal acute lung injury. New understanding of these interactions is essential to developing new treatments, which is becoming critically important in this era of worsening bacterial resistance to antibiotics.

At all levels of training, Dr. Hook has been strongly committed to building a basic and translational research career in lung disease and lung biology. In medical school she was awarded a Research Fellowship from the University of Wisconsin Institute for Clinical and Translational Research to carry out her clinical research project. She continued her research training during her residency and clinical fellowship, forming a solid foundation in the clinical research of severe lung diseases and lung transplant candidate selection under the mentorship of Dr. David Lederer. She joined the Bhattacharya laboratory in 2013 as a T32 Research Fellow to gain training in the biology of lung infection and acute lung injury. Since then she has garnered a highly competitive 5-year research grant, numerous invited lectures and awards, and favorable national and international attention for her work. Her ongoing project uses real-time optical imaging of live, intact mouse and transplant-declined human lungs in order to learn new mechanisms by which the common and virulent bacteria, Staphylococcus aureus, cause lung injury. It is her hope that, by incorporating both basic and clinical approaches, her research will lead to new treatments for the fatal lung injury caused by severe lung infection.

Education and Training

Undergraduate:
B.S. in Molecular Biology, University of Wisconsin, Madison, WI, 2004
Medical School:
University of Wisconsin School of Medicine and Public Health (UWSMPH), Madison, WI, 2008
Internship:
Department of Medicine, New York University Medical Center, NY, NY, 2008-2009
Residency:
Department of Medicine, Columbia University Medical Center (CUMC), NY, NY, 2009-2011
Fellowships:
Research Fellowship, Institute for Clinical and Translational Research, UWSMPH, 2004
Clinical Fellowship, Pulmonary and Critical Care Medicine, CUMC, 2011-2014
Research Fellowship (T32 HL105323), Lung Biology Laboratory, Columbia University, 2013-2015

Honors and Awards

  • 2016-2021 American Heart Association Fellow-to-Faculty Transition Award (application scored in 0.1 percentile)
  • 2016 Invited Lecture, Gordon Research Conference on the Biology of Acute Respiratory Infection, Galveston, TX
  • 2016 Abstract Scholarship, American Thoracic Society (ATS) Assembly on Respiratory Cell and Molecular Biology
  • 2015-2017 Stony Wold-Herbert Fund, Inc. Research Training Fellowship
  • 2014 Abstract Award, ATS Assembly on Respiratory Cell and Molecular Biology
  • 2014 Travel Award, Federation of American Societies for Experimental Biology (FASEB)
  • 2012 Travel Award, Assembly on Clinical Problems, ATS
  • 2010 Arnold P. Gold Foundation Award for Humanism and Excellence in Teaching, conferred by the Columbia University College of Physicians and Surgeons Class of 2012
  • 2008 Alpha Omega Alpha
  • 2008 Gold Humanism Honor Society
  • 2007 Wisconsin Medical Society Foundation Presidential Scholar Award for Medical Leadership
  • 2006 Wisconsin Medical Alumni Association Scholarship for Leadership
  • 2004 Phi Beta Kappa

Other Experience and Professional Membership

  • 2018 Co-Chair, Gordon Research Seminar on the Biology of Acute Respiratory Infection
  • 2017 Program Committee Member, American Thoracic Society Assembly on Respiratory Cell & Molecular Biology
  • 2017 Early Career Professionals Working Group Member, American Thoracic Society Assembly on Respiratory Cell & Molecular Biology
  • 2017 Member, Columbia Virginia Kneeland Frantz Society for Women Faculty
    2016 Junior Faculty Panelist, Columbia Department of Medicine Academic and Research Career Guidance Seminar for Fellows
  • 2014 Selected Lecturer, FASEB Conference on the Lung Epithelium in Health and Disease, Saxtons River, VT
  • 2012, 2014, 2016 Selected Lecturer, American Thoracic Society Mini Symposia
  • 2006-2007 Member, Wisconsin Medical Society Council on the Health of the Public
  • 2005-2006 Member, Wisconsin Medical Society Board of Directors
  • 2005-2006 President, Medical Student Association, University of Wisconsin School of Medicine and Public Health

Clinical

For appointments: 

Lung Transplantation Program
Columbia University Medical Center
622 West 168th Street, PH-14 Room 104
New York, NY 10032
Phone: 212-305-7771| Fax: 212-342-5382

Specialties

  • Pulmonary Disease Medicine
  • Critical Care Medicine
  • Lung Transplantation

Clinical Expertise

  • Advanced Lung Disease
  • Lung Transplantation

Board Certifications

  • Critical Care Medicine Diplomate, 2014
  • Pulmonary Disease Diplomate, 2013
  • Internal Medicine Diplomate, 2011

Research

Contact Information: 

Lung Transplantation Program
Division of Pulmonary, Allergy, and Critical Care Medicine
Columbia University Medical Center
622 West 168th Street, PH-14 Room 104
New York, NY 10032
Administrative assistant, Maylin Rincon: mer2159@cumc.columbia.edu
Phone: 212-305-7771
Fax: 212-342-5382

Lung Biology Laboratory
Division of Pulmonary, Allergy, and Critical Care Medicine
Columbia University Medical Center
630 West 168th Street, BB 8 Room 812
New York, NY 10032
Laboratory manager, Rashmi Patel: rnp2105@cumc.columbia.edu
Phone: 212-305-7310
Fax: 212-305-6701
 

Research Interests

  • Host-pathogen interactions in lung infection
  • Mechanisms of acute lung injury, alveolar barrier deterioration, and alveolar repair
  • Real-time optical imaging of live, intact mouse and human lungs
  • Use of genetic indicators based on fluorescence resonance energy transfer (FRET) in live lung imaging
  • Clinical prognostication in patients with idiopathic pulmonary fibrosis
  • Candidate selection for lung transplantation

Funding

  • AHA Fellow-to-Faculty Transition Award: Pulmonary microvascular responses to methicillin-resistant Staphylococcus aureus lung infection (PI: Hook; 7/1/16-6/30/21)
  • Stony Wold-Herbert Fund Research Training Fellowship and Renewal (PI: Hook; completed)
  • NHLBI T32 HL105323: Columbia Training Program in Lung Science (PI: Bhattacharya; Fellow: Hook; completed)
  • Research Fellowship, University of Wisconsin Institute for Clinical and Translational Research: Self-rated health as a predictor of future functioning in older adults after a diagnosis of cancer (PI: Hook; completed)

Selected Publications

Peer-reviewed publications

  • Hook JL, Arcasoy SM, Zemmel D, Bartels MN, Kawut SM, Lederer DJ. Titrated oxygen requirement and prognostication in idiopathic pulmonary fibrosis. Eur Respir J. 2012;39(2):359-65. PMID 21885386.
  • Hook JL, Lederer DJ. Socioeconomic barriers to lung transplantation: balancing access and equity. Am J Respir Crit Care Med. 2012;186(10): 937-9. PMID 23155209.
  • Hook JL, Lederer DJ. Selecting lung transplant candidates: where do current guidelines fall short? Expert Rev Respir Med. 2012;6(1):51-61.PMID 22283579.

Published abstracts

  • Hook JL, Islam MN, Gusarova G, Parker D, Prince A, Bhattacharya J. Localized alveolar-bacterial interactions determine global lung injury by Staphylococcus aureus. In: American Thoracic Society International Conference Abstracts, Section B80: Mechanisms and Models of Acute Lung Injury. May 20-24, 2017; Washington, D.C. Abstract A4398.
  • Hook JL and Bhattacharya J. Staphylococcus aureus causes mitochondrial injury in live alveoli. In: ATS International Conference Abstracts, Section B97: Mitochondrial Dysfunction in the Development of Lung Disease. May 14-18, 2016; San Francisco, CA. Abstract A4597.
  • Hook JL, Islam MN, Westphalen K, Parker D, Prince A, Bhattacharya J. Alveolar curvatures determine Staphylococcus aureus-induced lung injury. In: ATS International Conference Abstracts, Section B101: Acute Lung Injury and Inflammation. May 15-20, 2015; Denver, CO. Abstract A3687.
  • Hook JL, Islam MN, Westphalen K, Cohen T, Prince A, Bhattacharya J. Alveolar retention of Staphylococcus aureus. Presented at: FASEB Conference, The Lung Epithelium in Health and Disease. July 27 – August 1, 2014; Saxtons River, VT. Abstract.
  • Hook JL, Islam MN, Westphalen K, Cohen TS, Prince AS, Bhattacharya J. Optical imaging of bacterial clearance in live alveoli. In: ATS International Conference Abstracts, Section C18: Not Just A Job, But An Adventure: Molecular Underpinnings of Acute Lung Injury. May 17-21,2014; San Diego, CA. Abstract A3963.

View Dr. Hook's full list of publications from PubMed