David Lederer, M.D., M.S.

Associate Professor of Medicine and Epidemiology (In Pediatrics)
Associate Division Chief for Clinical and Translational Research
Director, Advanced Lung Disease Program 
Co-director, Interstitial Lung Disease Program and NYP PFF Care Center [ColumbiaILD.org
Director, Pulmonary & Intensive Care Translational Outcomes Research (PICTOR) Group [PictorGroup.org]



Dr. Lederer is an attending physician at New York Presbyterian Hospital/Columbia University Medical Center where he cares for patients with interstitial lung diseases such as idiopathic pulmonary fibrosis. He is the principal investigator of two NHLBI-funded studies: the MESA Lung Fibrosis Study and the Lung Transplant Body Composition Study. He is a deputy editor of the Annals of the American Thoracic Society and sits on the editorial board of the American Journal of Respiratory and Critical Care Medicine and on the statistical editorial board for Thorax. Dr. Lederer is a Senior Medical Advisor for the Pulmonary Fibrosis Foundation and a standing member of the IRAP study section at the Center for Scientific Review at the NIH. He is a member of the Technical Advisory Committee for the Scientific Registry of Transplant Recipients and a member of the Research and Scientific Advisory Board of the American Lung Association. He blogs at www.pfdoc.org for patients with pulmonary fibrosis.

Dr. Lederer's research focuses on two related areas (1) enhancing the understanding of the causes of lung fibrosis in humans, and (2) improving outcomes after lung transplantation by investigating and improving candidacy for the procedure. He leads research efforts in the following areas:

  • Causes of interstitial lung disease
  • Frailty and obesity in lung transplantation
  • Novel therapies for idiopathic pulmonary fibrosis
  • Disparities in deceased donor organ allocation
  • Obesity, sleep apnea, and lung injury

Education and Training

B.S. in Biology, Adelphi University, Garden City, NY, 1995
M.S., Biostatistics, Columbia University Mailman School of Public Health, 2007
Medical School:
SUNY Downstate College of Medicine, Brooklyn, NY, 1999
Department of Medicine, Columbia Presbyterian Medical Center, NY, NY, 1999-2000
Department of Medicine, Columbia Presbyterian Medical Center, 2000-2002
Chief Residency:
Department of Medicine, Columbia Presbyterian Medical Center, 2002-2003
Pulmonary and Critical Care Fellow, Columbia Presbyterian Medical, Center, 2003‑2005
Research Fellow, Columbia Presbyterian Medical Center, New York T32 HL072739, 2005-2006

Honors and Awards

  • 2014 Harold and Golden Lamport Award for Excellence in Clinical Science Research
  • 2014 Ewig Clinical Scholar (CUMC Teaching Award)
  • 2013-2015 New York Super Doctors
  • 2012-2015 Top Doctor: New York Metro Area, US News & World Report/Castle Connolly
  • 2008-2011 Herbert and Florence Irving Scholar
  • 2008-2011 Robert Wood Johnson Physician Faculty Scholar

Other Experience and Professional Membership


  • 2015-2019 NIH/CSR: Standing member, IRAP study section, Center for Scientific Review
  • 2015-2017 Chair, Planning Committee, Clinical Problems Assembly, American Thoracic Society
  • 2015 Member, SRTR Technical Advisory Committee (www.srtr.org/Stac)
  • 02/2015 NIH/NHLBI MPOR-MA study section: K23, K24, K25 Career Development Award
  • 11/2014 VA-ORD RR&D Small Projects in Rehabilitation Research (SPiRE) (I21), RFA: RX-14-009
  • 10/2014 NIH/NHLBI ZHL1 CSR-X (O1) 1: K23, K24, K25 Career Development Award
  • 09/2014 NIH/CSR: IRAP ad hoc reviewer (R01/R03)
  • 07/2014 NIH/CSR ZRG1 RPHB-S (02) M: Member Conflict: Behavioral Interventions, Obesity, and Chronic Pain (R01)
  • 06/2014 NIH/NHLBI ZHL1 CSR-X (O1) 1: K23, K24, K25 Career Development Award
  • 2014 Senior Medical Advisor, Pulmonary Fibrosis Foundation, Education & Awareness
  • 2014 Member, Research and Scientific Advisory Board, American Lung Association
  • 03/2014 NIH/NHLBI ZRG1 PSE-Q (56): PAR-13-009: Secondary Dataset Analyses in Heart, Lung, and Blood Diseases and Sleep (R21)
  • 11/2013 National Health Service (NHS) National Institute for Health Research (NIHR) Clinician Scientist Programme review committee (K equivalent)
  • 11/2013 National Health Service (NHS) Scotland, Chief Scientist Office: Experimental and Translational Medicine Research Committee, Mail reviewer
  • 06/2013 NIH/CSR: IRAP ad hoc reviewer (R01/R03)
  • 02/2013 NIH/NHLBI SEP: Phase II Clinical Trials of Novel Therapies for Lung Diseases (UM1)
  • 11/2012 NIH/NHLBI ZHL1 CSR-P (F1): Maximizing the scientific value of the NHLBI biologic specimen repository: Scientific opportunities (R21) (UM1)
  • 02/2012 NIH/NHLBI ZHL1 CSR-F (M1): Mentoring programs to promote diversity in health research (K01/R25)
  • 2012-2013 Member, NHLBI Workshop, Primary Prevention of Chronic Lung Diseases
  • 2011-2014 American Lung Association Research Training Fellowship Study Section


  • 2015 Statistical Editorial Board, Thorax
  • 2013 Editorial Board, American Journal of Respiratory and Critical Care Medicine
  • 2012 Deputy Editor, Annals of the American Thoracic Society


For appointments: 

Columbia ILD and PFF Care Center
Columbia University Medical Center
161 Fort Washington Ave, Room 3-321A
New York, NY 10032
Phone: 212-305-8203 | Fax: 212-305-8426


  • Pulmonary Disease Medicine
  • Lung Transplantation

Clinical Expertise

  • Interstitial lung disease
  • Idiopathic pulmonary fibrosis
  • Lung transplantation

Clinical Centers

Board Certifications

  • Internal Medicine Diplomate, 2002
  • Pulmonary Disease Diplomate, 2005
  • Critical Care Medicine Diplomate, 2006


Contact Information: 

Tatiana Blue
Research Coordination and Regulatory Core Director, (PICTOR) Group
Columbia University Medical Center
622 W. 168th Street | PH9-215 | New York | NY | 10032
Email: tjb2134@columbia.edu
Phone: 212.342.4167
Fax: 212.342.4525

Research Interests

  • Subclinical interstitial lung disease
  • Body composition and lung transplantation
  • Disparities in access to subspecialty pulmonary services and lung transplantation
  • Obstructive sleep apnea and alveolar injury

Visit PictorGroup.org for more information on Dr. Lederer's research.


Selected Publications

  1. Singer JP, Diamond JM, Gries CJ, McDonnough J, Blanc PD, Shah R, Dean MY, Hersh B, Wolters PJ, Tokman S, Arcasoy SM, Ramphal K, Greenland JR, Smith N, Heffernan P, Shah L, Shrestha P, Golden JA, Blumenthal N, Huang D, Sonett J, Hays S, Oyster M, Katz PP, Robbins H, Brown M, Leard LE, Kukreja J, Bacchetta M, Bush E, D'Ovidio F, Rushefski M, Raza K, Christie JD, Lederer DJ. Frailty phenotypes, disability, and outcomes in adult candidates for lung transplantation. Am J Respir Crit Care Med. In press. [Abstract]
  2. Bernstein EJ, Peterson ER, Sell JL, D'Ovidio F, Arcasoy SM, Bathon JM, Lederer DJ. Survival of adults with systemic sclerosis following lung transplantation: A nationwide cohort study. Arthritis Rheumatol 2015; 67(5):1314-22. [Abstract]  
  3. Singer JP, Peterson ER, Snyder ME, Katz PP, Golden JA, D'Ovidio F, Bacchetta M, Sonett JR, Kukreja J, Shah L, Robbins H, Van Horn K, Shah RJ, Diamond JM, Wickersham N, Sun L, Hays S, Arcasoy SM, Palmer SM, Ware LB, Christie JD, Lederer DJ. Body Composition and Mortality after Adult Lung Transplantation in the United States. Am J Respir Crit Care Med 2014;190(9):1012-21. [Abstract] [Full text
  4. Baldwin, MR, Arcasoy SM, Shah A, Sze J, Sonett JR, Lederer DJ. Hypoalbuminemia and early mortality after lung transplantation: a cohort study. Am J Transplant 2012;12(5):1256-67.  [Abstract] [Full text
  5. Hook JL, Arcasoy SM, Zemmel D, Bartels M, Kawut SM, Lederer DJ. Titrated oxygen requirement and prognostication in idiopathic pulmonary fibrosis. Eur Respir J 2012;39(2):359-65. [Abstract] [Full text
  6. Lederer DJ, Kawut S, Wikersham N, Winterbottom C, Bhorade S, Palmer S, Lee J, Diamond J, Wille K, Weinacker A, Lama V, Crespo M, Orens J, Sonett J, Arcasoy S, Ware L, Christie J. Obesity and primary graft dysfunction after lung transplantation: the LTOG Obesity Study. Am J Respir Crit Care Med 2011;184:1055-61. [Abstract] [Full text
  7. Lamas DJ, Kawut SM, Bagiella E, Philip N, Arcasoy SM, Lederer DJ. Delayed access and survival in idiopathic pulmonary fibrosis: a cohort study. Am J Respir Crit Care Med 2011;184:842-7. [Abstract] [Full text
  8. Lederer DJ, Enright PL, Kawut SM, Hoffman EA, Hunninghake G, van Beek EJR, Austin JHM, Jiang R, Lovasi GS, Barr RG. Cigarette smoking is associated with subclinical parenchymal lung disease: The MESA-Lung Study. Am J Respir Crit Care Med 2009;180(5):407-14. [Abstract] [Full text
  9. Lederer DJ, Wilt JS, D'Ovidio F, Bacchetta M, Shah L, Ravichandran S, Lenoir J, Klein B, Sonett JR, Arcasoy SM. Obesity and underweight are associated with an increased risk of death after lung transplantation. Am J Respir Crit Care Med 2009;180(9):887-95. [Abstract] [Full text
  10. Lederer DJ, Jelic S, Basner RC, Ishizaka A, Bhattacharya J. Circulating KL-6, a biomarker of lung injury, in obstructive sleep apnea. Eur Respir J 2009;33(4):793-6. [Abstract] [Full text
  11. Lederer DJ, Benn EKT, Barr RG, Wilt JS, Reilly G, Sonett JR, Arcasoy SM, Kawut SM. Racial differences in waiting list outcomes in COPD. Am J Respir Crit Care Med 2008;177(4):450-454. [Abstract] [Full text
  12. Lederer DJ, Arcasoy SM, Barr RG, Wilt JS, Bagiella E, D'Ovidio F, Sonett JR, Kawut SM. Racial and ethnic disparities in idiopathic pulmonary fibrosis: A UNOS/OPTN database analysis. Am J Transplant 2006;6(10):2436-42. [Abstract] [Full text
  13. Lederer DJ, Arcasoy SM, Wilt JS, D'Ovidio F, Sonett JR, Kawut SM. Six-minute walk distance predicts waiting list survival in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2006;174(6):659-64. [Abstract] [Full text

View Dr. Lederer's full list of publications from PubMed