Christine Kim Garcia, MD, PhD

Frode-Jensen Professor of Medicine, Pulmonary Division
Columbia University Irving Medical Center

Bio

Christine Garcia received both her medical and graduate degrees from the University of Texas Southwestern Medical Center in 1996. She trained in Internal Medicine and Pulmonary and Critical Care Medicine at UT Southwestern and was appointed as a member of its faculty from 2005 through 2018. In October 2018, she joined Columbia University Irving Medical Center as the Frode Jensen Professor of Medicine and the Associate Director of the Division of Pulmonary, Allergy and Critical Care Medicine.

Education and Training

Undergraduate:
B.S. in Chemistry, Texas A&M University, College Station, TX
Medical School:
M.D., Ph.D. in Molecular Genetics, UT Southwestern Medical Center, Dallas, TX
Residency:
Resident in Internal Medicine, UT Southwestern Medical Center, Dallas, TX
Fellowship(s):
Fellow in Pulmonary and Critical Care Medicine, UT Southwestern Medical Center, Dallas, TX

Other Experiences and Professional Memberships

  • Mentor for Postdoctoral and Pulmonary Research Fellows, Medical and Graduate Students
  • Ad hoc Reviewer for various NIH study sections, 2012-present; Standing member of NIH Infectious Disease, Reproductive Health and Asthma/Pulmonary Conditions (IRAP), 2013-2017
  • Medical Advisory Board, Pulmonary Fibrosis Foundation
  • ABIM Board Certified in Pulmonary Medicine and Critical Care Medicine
  • Alpha Omega Alpha
  • American Thoracic Society
  • American College of Chest Physicians
  • Society of Critical Care Medicine
  • American Society for Biochemistry and Molecular Biology
  • American Association for Cancer Research
  • American Society of Human Genetics
  • Clinical Scientist Development Award, Doris Duke Charitable Foundation
  • Medial Scholar Award, Charles E. Culpeper Foundation
  • Parker B. Francis Fellowship Award in Pulmonary Research
  • American Society for Clinical Investigation

Research

Contact Information: 

Pulmonary Genetics Laboratory
William H. Black Building
650 W 168th St, 9-905
New York, NY 10032
P: 212.304.7658
ckg2116@cumc.columbia.edu

Administrator
Josephine Melendez
Email: jm3913@cumc.columbia.edu

Selected Publications

  1. Newton CA, Zhang D, Oldham JM, Kozlitina J, Ma S-F, Martinez JF, Raghu G, Noth I and Garcia CK. Telomere Length and Use of Immunosuppressive Medications in Idiopathic Pulmonary Fibrosis. Am. J. Respir Crit Care Med. 2018 Dec 19 [Epub ahead of print]; PMID: 30566847. Commentary: Am. J. Respir Crit Care Med. 2019 Jan 9 [Epub ahead of print] PMID: 30624965.
  2. Maryoung L, Yue Y, Young A, Newton CA, Barba C, van Oers NSC, Wang RC and Garcia CK. Somatic Promoter Mutations in TERT Counterbalance Germline Loss-of-Function Telomerase Mutations, J Clin Invest. 2017 Mar 1; 127(3): 982-6. PMID: 28192371.
  3. Newton CA, Batra K, Torrealba J, Kozlitina J, Glazer CS, Aravena C, Meyer K, Raghu G, Collard HR and Garcia CK. Telomere-Related Lung Fibrosis is Diagnostically Heterogeneous but Uniformly Progressive, Eur Respir J. 2016 Dec; 48(6): 1710-1720; PMID: 27540018.
  4. Stuart BD, Choi J, Zaidi S, Xing C, Holohan B, Chen R, Choi M, Dharwadkar P, Torres F, Girod CE, Weissler J, Fitzgerald J, Kershaw C, Klesney-Tait J, Mageto Y, Shay JW, Ji W, Bilguvar K, Mane S, Lifton RP, and Garcia CK. Exome Sequencing Links Mutations in PARN and RTEL1 with Familial Pulmonary Fibrosis and Telomere Shortening. Nat Genet. 2015 May; 47(5): 512-7. PMID: 25848748. Commentary: Lancet Respir Med 3: 428 (2015).
  5. Stuart BD, Lee JS, Kozlitina J, Noth I, Devine MS, Glazer CS, Torres F, Kaza V, Girod CE, Jones KD, Elicker BM, Ma S-F, Vij R, Collard HR, Wolters PJ and Garcia CK. Effect of telomere length on survival in idiopathic pulmonary fibrosis: an observational study with independent validation. Lancet Respir Med. 2014 Jul; 2(7): 557-65. PMID: 24948432. Commentary: Lancet Respir Med 2:513-4 (2014) and Lancet Respir Med 2:507 (2014).
  6. Diaz de Leon A, Cronkhite JT, Yilmaz C, Brewington C, Wang R, Xing C, Hsia CCW and Garcia CK. Subclinical Lung Disease, Macrocytosis and Premature Graying in Kindreds with Telomerase (TERT) Mutations. Chest 2011 Sep; 140(3):753-63. PMID: 21349926.
  7. Wang Y, Kuan PJ, Chao X, Cronkhite JT, Torres F, Rosenblatt RL, DiMaio JM, Kinch LN, Grishin NV, Garcia CK. Genetic defects in surfactant protein A2 associated with pulmonary fibrosis and lung cancer. Am J Hum Genet. 2009 Jan; 84(1):52-9. PubMed PMID: 19100526.
  8. Cronkite JT, Xing C, Raghu G, Chin K, Torres F, Rosenblatt RL, Garcia CK. Telomere shortening in familial and sporadic pulmonary fibrosis. Am J Respir Crit Care Med. 2008 Oct 1; 178(7):729-37. PubMed PMID: 18635888.
  9. Tsakiri KD, Cronkhite JT, Kuan PJ, Xing C, Raghu G, Weissler JC, Rosenblatt RL, Shay JW, Garcia CK. Adult-onset pulmonary fibrosis caused by mutations in telomerase. Proc Natl Acad Sci U S A. 2007 May 1; 104(18):7552-7. PubMed PMID: 17460043.
  10. Graham RB, Nolasco M, Peterlin B, Garcia CK. Nonsense mutations in folliculin presenting as isolated spontaneous pneumothorax in adults. Am J Resp Crit Care Med. 2005 Jul 1; 172(1):39-44. PubMed PMID: 15805188.

View Dr. Garcia's full list of publications from PubMed

Current Grant Support

NIH NHLBI 2R01-HL093096, Pulmonary Fibrosis and Telomerase Dysfunction
Role: Principal Investigator
Annual amount: $250,000 (direct)
Award period: 7/1/2015 - 4/30/2020