Christian Schindler, M.D., Ph.D.

Associate Professor of Microbiology & Immunology
Associate Professor of Medicine


Dr. Christian Schindler is Associate Professor of Microbiology & Immunology and Associate Professor of Medicine. Please visit his website at the Department of Mircobiology & Immunology for more details.

Education and Training

University of Pennsylvania, 1978
PhD, New York University School of Medicine, 1985
Medical School:
New York University School of Medicine 1986
Internal Medicine, Albert Einstein Medical Center, Jacobi Hospital, 1985-1986
Internal Medicine, Albert Einstein Medical Center, Jacobi Hospital, 1986-1988
Endocrinology, Cornell Medical Center / Memorial Sloan-Kettering Cancer Center, 1988-1992
Postdoctoral fellow with Dr. James E. Darnell, Jr., Rockefeller University, New York, NY, 1989-1992

Selected Honors and Awards

  • McDonnell Scholar, 1993
  • DeWitt S. Goodman Fellow, 1994
  • The Doctor Harold and Golden Lamport Award for Excellence in Clinical Science Research, 1996
  • Scholar of the Leukemia Society of America, 1996-2001
  • Burroughs Wellcome Clinical Scientist Award in Translational Research, 1998-2002
  • Member of the American Society of Clinical Investigation, 1998-
  • Member of the Editorial Board of the Journal of Clinical Investigation, 2002-


Contact Information: 

Schindler Laboratory
Hammer Health Sciences Center
701 W. 168th Street, Rm 1212
New York, NY 10032
P: (212) 305-6407
Lab: (212) 305-5380
F: (212) 543-0063

Research Interests

Role of the JAK-STAT pathway in cytokine signal transduction. For more information, visit

Selected Publications

  1. Farlik, M., Reutterer, B., Schindler, C., Greten, F., Vogl, C., Muller, M. and Decker, T. (2010) Nonconventional initiation complex assembly by STAT and NF-kappaB transcription factors regulates nitric oxide synthase expression. Immunity 33: 25-34.
  2. Schindler, C. and Plumlee, C. (2008) IFN-Is pen the JAK-STAT pathway. Sem. Cell Dev. Biol. 19:311-318. 
  3. Melillo, J.A., Song, L., Bhagat, G., Blazquez, A.B., Plumlee, C.R., Lee, C., Berin, C., Reizis, B. and Schindler, C. (2010) Dendritic cell (DC)-specific targeting reveals Stat3 as a negative regulator of DC function. J. Immunol. 184: 2638-2645.
  4. Plumlee, C.R., Lee, C., Beg, A.A., Decker, T., Shuman, H.A. and Schindler, C. (2009) Interferons direct an effective innate response to Legionella pneumophila infection. J. Biol. Chem. 284:30058-30066. 
  5. Martin, F.J., Gomez, I.M., Wetzel, M., Memmi, G., O'Seaghdha, M., Soong G., Schindler, C. and Prince, A. (2009) S. aureus activates type I IFN signaling through the Xr repeated sequences of protein A. J. Clin. Invest. 115: 1931-1939. 
  6. Zhao, W., Lee, C., Piganis, R., Plumlee, C., de Weerd, N., Hertzog, P.J. and Schindler, C. (2008) A conserved IFN-alpha receptor tyrosine motif directs the biological response to type I IFNs. J. Immunol. 180: 5483-5489. 
  7. Schindler, C. and Plumlee, C. (2008) IFN-Is pen the JAK-STAT pathway. Sem. Cell Dev. Biol. 19:311-318. 
  8. Zhao, W., Cha, E.N., Lee, C., Park, C.Y. and Schindler, C. (2007) Stat2-dependent regulation of MHC class II expression. J. Immunol. 179: 463-471. 
  9. Schindler, C., Levy, D.E. and Decker, T. (2007) JAK-STAT signaling: from interferons to cytokines. J. Biol. Chem. 282: 20059-20063. 
  10. Kisseleva, T., Song, L., Vorontchikhina, M., Feirt, N., Kitajewski, J. and Schindler, C. (2006) NFkB regulation of endothelial cell function during LPS toxemia and cancer. J. Clin. Invest. 116:2955-2953.
  11. Song, L., Battacharya, S., Yunis, A.A., Lima, C.D. and Schindler, C. (2006) SUMO modification of Stat1. Blood 108: 3237-3244. 
  12. Song, L., Leung, C. and Schindler, C. (2001) Lymphocytes are important in atherosclerosis. J. Clin. Invest. 108: 251-259. 
  13. Park, C., Li, S., Cha, E. and Schindler, C. (2000) Immune response in Stat2 knock-out mice.Immunity 13: 795-804. 
  14. Azam, M., Lee, C., Strehlow, I. and Schindler, C. (1997) Functional distinct isoforms of Stat5 are generated by protein processing. Immunity 6: 691-701. 
  15. Gupta, S., Pablo, A.M., Jiang, X-c., Wang, N., Tall. A.R. and Schindler, C. (1997) IFN-gamma potentiates atherosclerosis in apoE knock-out mice. J. Clin. Invest. 99: 2752-2761. 
  16. Schindler, C., Shuai, K., Prezioso, V. and Darnell, J.E. (1992) Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor. Science 257: 809-813.

Medical Specialties

  • Internal Medicine Endocrinology