Christian Schindler, M.D., Ph.D.

Associate Professor of Microbiology & Immunology
Associate Professor of Medicine

Bio

Dr. Christian Schindler is Associate Professor of Microbiology & Immunology and Associate Professor of Medicine. Please visit his website at the Department of Mircobiology & Immunology for more details.

Education and Training

Undergraduate:
University of Pennsylvania, 1978
Graduate:
PhD, New York University School of Medicine, 1985
Medical School:
New York University School of Medicine 1986
Internship:
Internal Medicine, Albert Einstein Medical Center, Jacobi Hospital, 1985-1986
Residency:
Internal Medicine, Albert Einstein Medical Center, Jacobi Hospital, 1986-1988
Fellowship(s):
Endocrinology, Cornell Medical Center / Memorial Sloan-Kettering Cancer Center, 1988-1992
Postdoctoral fellow with Dr. James E. Darnell, Jr., Rockefeller University, New York, NY, 1989-1992

Selected Honors and Awards

  • McDonnell Scholar, 1993
  • DeWitt S. Goodman Fellow, 1994
  • The Doctor Harold and Golden Lamport Award for Excellence in Clinical Science Research, 1996
  • Scholar of the Leukemia Society of America, 1996-2001
  • Burroughs Wellcome Clinical Scientist Award in Translational Research, 1998-2002
  • Member of the American Society of Clinical Investigation, 1998-
  • Member of the Editorial Board of the Journal of Clinical Investigation, 2002-

Research

Contact Information: 

Schindler Laboratory
Hammer Health Sciences Center
701 W. 168th Street, Rm 1212
New York, NY 10032
P: (212) 305-6407
Lab: (212) 305-5380
F: (212) 543-0063
Email: cws4@columbia.edu

Research Interests

Role of the JAK-STAT pathway in cytokine signal transduction. For more information, visit www.microbiology.columbia.edu/faculty/schindler.html.

Selected Publications

  1. Farlik, M., Reutterer, B., Schindler, C., Greten, F., Vogl, C., Muller, M. and Decker, T. (2010) Nonconventional initiation complex assembly by STAT and NF-kappaB transcription factors regulates nitric oxide synthase expression. Immunity 33: 25-34.
  2. Schindler, C. and Plumlee, C. (2008) IFN-Is pen the JAK-STAT pathway. Sem. Cell Dev. Biol. 19:311-318. 
  3. Melillo, J.A., Song, L., Bhagat, G., Blazquez, A.B., Plumlee, C.R., Lee, C., Berin, C., Reizis, B. and Schindler, C. (2010) Dendritic cell (DC)-specific targeting reveals Stat3 as a negative regulator of DC function. J. Immunol. 184: 2638-2645.
  4. Plumlee, C.R., Lee, C., Beg, A.A., Decker, T., Shuman, H.A. and Schindler, C. (2009) Interferons direct an effective innate response to Legionella pneumophila infection. J. Biol. Chem. 284:30058-30066. 
  5. Martin, F.J., Gomez, I.M., Wetzel, M., Memmi, G., O'Seaghdha, M., Soong G., Schindler, C. and Prince, A. (2009) S. aureus activates type I IFN signaling through the Xr repeated sequences of protein A. J. Clin. Invest. 115: 1931-1939. 
  6. Zhao, W., Lee, C., Piganis, R., Plumlee, C., de Weerd, N., Hertzog, P.J. and Schindler, C. (2008) A conserved IFN-alpha receptor tyrosine motif directs the biological response to type I IFNs. J. Immunol. 180: 5483-5489. 
  7. Schindler, C. and Plumlee, C. (2008) IFN-Is pen the JAK-STAT pathway. Sem. Cell Dev. Biol. 19:311-318. 
  8. Zhao, W., Cha, E.N., Lee, C., Park, C.Y. and Schindler, C. (2007) Stat2-dependent regulation of MHC class II expression. J. Immunol. 179: 463-471. 
  9. Schindler, C., Levy, D.E. and Decker, T. (2007) JAK-STAT signaling: from interferons to cytokines. J. Biol. Chem. 282: 20059-20063. 
  10. Kisseleva, T., Song, L., Vorontchikhina, M., Feirt, N., Kitajewski, J. and Schindler, C. (2006) NFkB regulation of endothelial cell function during LPS toxemia and cancer. J. Clin. Invest. 116:2955-2953.
  11. Song, L., Battacharya, S., Yunis, A.A., Lima, C.D. and Schindler, C. (2006) SUMO modification of Stat1. Blood 108: 3237-3244. 
  12. Song, L., Leung, C. and Schindler, C. (2001) Lymphocytes are important in atherosclerosis. J. Clin. Invest. 108: 251-259. 
  13. Park, C., Li, S., Cha, E. and Schindler, C. (2000) Immune response in Stat2 knock-out mice.Immunity 13: 795-804. 
  14. Azam, M., Lee, C., Strehlow, I. and Schindler, C. (1997) Functional distinct isoforms of Stat5 are generated by protein processing. Immunity 6: 691-701. 
  15. Gupta, S., Pablo, A.M., Jiang, X-c., Wang, N., Tall. A.R. and Schindler, C. (1997) IFN-gamma potentiates atherosclerosis in apoE knock-out mice. J. Clin. Invest. 99: 2752-2761. 
  16. Schindler, C., Shuai, K., Prezioso, V. and Darnell, J.E. (1992) Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor. Science 257: 809-813.

Medical Specialties

  • Internal Medicine Endocrinology