Aimee M. Layton, PhD

Associate Research Scientist in the Department of Medicine


Dr. Aimee M. Layton, PhD Associate Researcher of Medicine. Dr. Layton has been a clinical exercise physiologist here at Columbia University Medical Center for ten years. Her research focuses on the impact of pulmonary disease on ventilatory mechanics and physiology. While obtaining her Bachelors degree at the University of Massachusetts, Dr. Layton worked in the biomechanics laboratory under Dr. Hamill studying movement disorders in runners. However, during an internship here at Columbia University Medical Center in the Pediatric Exercise Laboratory, she discovered her passion for clinical physiology. Dr. Layton obtained her Master degree from Teachers College, Columbia University and began studying and testing adult patients with pulmonary disease. She obtained her Ph.D from the Graduate School of Arts and Science, Columbia University in 2013 and joined the Division of Pulmonary, Allergy and Critical Care shortly after. Dr. Layton was the first American and first female to publish in the field of exercise ventilatory mechanics using Optoelectronic Plethysmography. She has given invited international talks on her research and servers as a reviewer for multiple journals. Her current research entails investigating changes in ventilatory mechanics before and after lung volume reduction surgery, with a goal of better understanding mechanisms behind exercise intolerance in COPD and dynamic hyperinflation.

Education and Training

B.S. in Exercise Science, University of Massachusetts Amherst, Amherst, MA May 2005
Medical School:
Columbia University, Teacher’s College, New York, NY 2007
D. Phil, Graduate School of Arts and Sciences, Columbia University, 2013

Professional Membership

  • Member of the American College of Sports Medicine (ACSM)
  • Member of the International Society of Heart & Lung Transplantion (ISHLT)
  • Member of the American Thoracic Society (ATS)
  • Member of the American Physiology Society (APS)


Research Interests

  • Exercise ventilatory mechanics in patients with Emphysema
  • Abnormalities in ventilatory mechanics in the endurance athlete
  • Predicting prognosis using exercise testing in patients with lung disease and post operative outcomes

Selected Publications

  1. Layton AM. Update in Exercise Testing. Current Physical Medicine and Rehabilitation Reports. Article accepted for publication June 22, 2015
  2. Layton AM, Whitworth JW, Peacock J, Bartels MN, Jellen PA, Thomashow BM. Feasibility and Acceptability of Utilizing a Smartphone Based Application to Monitor Outpatient Discharge Instruction Compliance in Cardiac Disease Patients Peri-discharge from Hospitalization. Int J Telemed Appl. Accepted for publication 2014 Nov 11.
  3. Layton AM, Armstrong HF, Moran SL, Guenette JA, Thomashow BM, Jellen PA, Bartels MN, Sheel AW, Basner RC. Quantification of Improvements in Static and Dynamic Ventilatory Measures Following Lung Volume Reduction Surgery for Severe COPD. JCOPF. 2015; 2 (1).
  4. Layton AM, Moran SL, Garber CE, Armstrong HF, Basner RC, Thomashow BM, Bartels MN. Optoelectronic plethysmography compared to spirometry during maximal exercise. Respir Physiol Neurobiol. 2013 Jan 15;185(2):362-8.
  5. Armstrong HF, Gonzalez-Costello J, Jorde UP, Ginsburg ME, Layton AM, Thomashow BM, Bartels MN. The effect of lung volume reduction surgery on chronotropic incompetence. Respir Med. 2012 Oct;106(10):1389-95
  6. Layton AM, Garber CE, Basner RC, Bartels MN. An assessment of pulmonary function testing and ventilatory kinematics by optoelectronic plethysmography. Clin Physiol Funct Imaging. 2011 Sept; 31(5):333-6.
  7. Layton AM, Garber CE, Thomashow BM, Gerardo RE, Emmert-Aronson BO, Armstrong HF, Basner RC, Jellen P, Bartels MN. Exercise ventilatory kinematics in endurance trained and untrained men and women. Resp Physiol Neurbiol. 2011 Sep 15; 178 (2):223-9.
  8. Bartels MN, Armstrong HF, Gerardo RE, Layton AM, Emmert-Aronson BO, Sonett JR, Arcasoy SM. Evaluation of pulmonary function and exercise performance by cardiopulmonary exercise testing before and after lung transplantation. Chest. 2011 Dec;140(6):1604-11.
  9. Pitsikoulis C, Bartels MN, Gates G, Rebmann RA, Layton AM, De Meersman RE. Sympathetic drive is modulated by central chemoreceptor activation. Respir Physiol Neurobiol. 2008 Dec 31;164(3):373-9. Epub 2008 Sep 20.

View Dr. Layton's full list of publications from PubMed