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In Vivo

CUMC At Large

Dr. Lewis is Honored
Dr. Lewis is Honored Linda Lewis, M.D., outgoing senior associate dean for student affairs, was praised at a reception in June for her "glorious legacy to the school, students, and alumni." Gerald Fischbach, M.D., executive vice president and dean, told the group of colleagues, alumni, students, and friends "her personality has pervaded this school and made it what it is." Pictured at right at the reception, Dr. Lewis with Lewis Rowland, M.D., professor and former chairman of neurology.

SDOS Partners with Japanese Institution A delegation of 40 senior administrators, faculty and alumni of Osaka Dental University in Japan visited the School of Dental and Oral Surgery in July as part of an educational and research agreement between the two universities.

SDOS Partners with Japanese Institution
Representatives from the Osaka Dental University formally signed the partnership agreement. It involves joint research projects, the exchange of reference materials and participation in postdoctoral specialty programs and education courses by faculty and students from both universities. The Japanese dentists also participated in a week-long comprehensive course in dental implantology.

"There is a growing recognition that important oral health care problems exist throughout the world, and that oral infections can be risk factors for systemic diseases. Only by working across international borders will we be able to address this problem," says Ira Lamster, D.D.S., dean of SDOS, front row, second from right in photo above.

Students from Osaka Dental University are expected to come to SDOS to participate in training and ongoing research for six months to a year. Columbia also plans to send faculty and students to Japan for education and research programs.

P&S Summer Minority Fellowship Program Reaches New Milestone

P&S Summer Minority Fellowship Program Reaches New Milestone More than 50 minority students from Hunter College in New York have now had the opportunity to study at P&S for eight weeks, thanks to the successful joint venture between the two institutions started in 2001 by Andrew Marks, M.D., chairman of physiology & cellular biophysics, Clyde and Helen Wu Professor of Molecular Cardiology and director of the Center for Molecular Cardiology. Above is a photograph of Hunter graduate Lori Elwick presenting her research in August to 2004 Nobel Laureate Richard Axel, Dr. Marks and high school students attending the event.

Summer Program Changes Lives
Summer Program Changes Lives The Summer Medical and Dental Education Program (SMDEP), funded by the Robert Wood Johnson Foundation, is an intensive six-week training program for underrepresented and economically disadvantaged pre-med and pre-dent college students, located at 11 major medical centers around the country. The students are given basic science courses that reflect the first year of medical and dental school and test prep for the MCAT and the DAT exam. Clinical experiences are given at New York-Presbyterian Hospital, at the medical and dental schools, and at affiliated clinical sites in Northern Manhattan such as Harlem Hospital and the Community DentCare Network. Of the 14 graduates of Columbia's SMDEP, two students will graduate from SDOS in 2007, two are enrolled in SDOS, class of 2008 and three have been accepted into the class of 2009.

In the photo above are the 14 pre-dental SMDEP students during their white coat ceremony accompanied by Joseph M. McManus, D.D.S., assistant dean, SDOS Admissions, left; Dennis A. Mitchell, D.D.S., assistant dean, SDOS diversity and multicultural affairs director and director SMDEP dental program, fourth from left; SDOS student T.A., Robert Mensah Class'07 (and SMDEP graduate summer '03), second from right; and Martin J. Davis, D.D.S., associate dean, SDOS student and alumni affairs, right.

Stem Cell Forum Emphasizes Broad Range of Projects

Several hundred guests in June attended a special forum held for donors at the St. Regis Hotel in New York that highlighted Columbia University's new Stem Cell Initiative. Gerald Fischbach, M.D., executive vice president and dean; CUMC Capital Campaign Chairman Roy Vagelos, M.D., Eric Rose, M.D., Chairman of the Department of Surgery; Rudolph Leibel, M.D., professor of pediatrics, and Timothy Pedley, M.D., Chairman of the Department of Neurology, presented the range of the medical center's research projects involving stem cells. With strengths in developmental biology, transplantation, neuroscience, cardiology, dermatology and diabetes, Columbia continues to advance in this emerging field. The speakers shared objectives for scientific inquiry at the medical center involving stem cells in the coming months and years. To hear the speakers' presentations and learn about the Stem Cell Initiative, visit the new Web Site,

Working Toward Cures

Animal-based research allows Columbia's biomedical researchers to better understand today's most intransigent diseases – diabetes, heart disease, and neurodegenerative disorders like Alzheimer's.


Researchers in the Naomi Berrie Diabetes Center use mice to look for genes that trigger Type 2 diabetes in hopes of finding better treatments.

Heart Disease

• Researchers in the Helen and Clyde Wu Center for Molecular Cardiology used mice to find the molecules in heart muscle responsible for arrhythmia, and are now testing potential drugs to prevent sudden cardiac arrest.
• During heart surgery, blood-thinning medications are traditionally used to prevent blood clots from forming in the heart-lung machine, but the same medication can also cause a patient to bleed to death. Scientists in the Department of Surgery have developed a drug that selectively controls coagulation, allowing wounds to clot while preventing clotting in a heart-lung machine. The drug has been successful in animals and will soon be tested in humans.

Neurodegenerative Disease

• Neuroscientists at Columbia have devised drugs that reverse memory loss in mice. A biotech company is testing whether one of these drugs restores memory and forestalls the onset of Alzheimer's.
• Scientists at Columbia and the University of Nebraska continue to develop the first vaccine targeting Parkinson's disease, following a successful test in mice in which the vaccine prevented neuron death in the brain.

New Web Site Profiles Animal Research

A new Web Site aims to clarify the essential role that animals play in medical research here at Columbia – recognizing the countless advances that would not have been possible without animal-based research.

Columbia is committed to the use of animals in biomedical research only when all other options, such as cell cultures and computer models, cannot provide the needed answers or when it is too early in the discovery process to study therapies in humans. All research proposals involving animals must undergo rigorous review before any research may begin. The University's exacting standards for the care and oversight of animals are summarized on the site.

Visit the Web Site at http://www.cumc.columbia. edu/research/animal to read about medical milestones achieved by using animal-based research. Columbia's important discoveries and ongoing research are detailed there. The site also includes frequently asked questions; an overview of the national animal laboratory guidelines that Columbia follows and often exceeds; and links to additional resources.

Click on "Research Activities" on the CUMC home page, then click on the site link "Medical Research with Animals" to access the Web Site.

Dean's Distinguished Lecture in Basic Sciences

Tuesday, Sept. 13, 2005

"High Throughput Cell Biology and the Columbia Genome Center." Speaker: James E. Rothman, Ph.D., Director, the Judith P. Sulzberger Columbia Genome Center. P&S Alumni Auditorium, 4:30 to 6:30 p.m. Reception to follow in the Alumni Auditorium Lobby

Thomas Q. Morris Symposium

Monday, Sept. 19, 2005

"The Route to Patient Safety through Simulation in Medical Education." Speaker: David M. Gaba, M.D., Associate Dean for Immersive & Simulation-based Learning, Stanford University School of Medicine. P&S Alumni Auditorium, 4:30 to 6:30 p.m. Reception to follow in the Alumni Auditorium Lobby

New "Newsroom" Web Site

The Office of Communications & External Relations has launched a Web Site to keep reporters, the public and the CUMC community informed about new research, education news and other important announcements. You'll find features, press releases, expert resources and links to recent news stories featuring the medical center. Visit the site at