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Every five years, the Journal of Clinical Investigation changes the home of its scientific editors. U.S. medical schools and universities submit applications to an advisory board of the journal's publisher, the American Society for Clinical Investigation, which chooses the institution to be at the helm.

The board chose Columbia University Health Sciences for the fourth time to take over the editorship, with Dr. Andrew Marks, the new JCI editor as of March 2002, along with 18 other P&S faculty joining him as editors to help select articles for publication. Dr. Marks is the Wu Professor of Molecular Cardiology, professor of medicine and pharmacology, and director of the Center for Molecular Cardiology.

The group held a party launching the editorship last month at the New York Academy of Sciences, in Manhattan, with keynote speaker, Dr. Paul Marks '49, former vice president for Health Sciences and dean of the faculty of medicine at P&S, president emeritus of Memorial Sloan-Kettering Cancer Center, father of Andrew, and editor of JCI between 1966 and 1970.

JCI has a 78-year history highlighting advances in basic science that are relevant to human biology and diseases. "The need to have a high quality, peer-reviewed journal, such as JCI, that reports advances in biomedical research has never been greater," Dr. Andrew Marks says. "The impact of biomedical research on clinical practice is more immediate than ever."

Columbia investigators wishing to submit research to JCI should contact Dr. Barbara Cohen, executive editor, who will send the articles to outside editors, to prevent any potential conflicts of interest by Columbia-based editors. The journal, which is published twice monthly and available free online, http://www.jci.org/, receives approximately 4,000 manuscripts a year and publishes around 10 percent of them.

Besides Dr. Marks, the Columbia JCI editors are: deputy editors, Qais Al-Awqati and Ira A. Tabas; associate editors, Domenico Accili, Kathryn L. Calame, Leonard Chess, Riccardo Dalla-Favera, T. Conrad Gilliam, Joy Hirsch, Robert S. Kass, Rudolph L. Leibel, Beth Levine, Richard Mayeux, Alice Prince, Paul B. Rothman, Christian Schindler, and Alan Tall; senior editors, Wayne Hendrickson and Eric R. Kandel.

—Robin Eisner


The Irving Center for Clinical Research has announced five new Herbert and Florence Irving Scholars as part of its program to support young physician-investigators who are starting careers in patient-oriented research. Awardees each receive $50,000 per year for three years to support their research. The three-year research appointments go to:

Dr. Gaetano R. Barile, Herbert Irving Assistant Professor of Clinical Ophthalmology, who is studying new pharmacological approaches to block the cellular receptor for advanced glycation endproducts, known as RAGE, which is a key component in the development of diabetes complications. He is investigating drug therapies to prevent or reverse sight loss in people with diabetes.

Dr. Petra Kaufmann, Florence Irving Assistant Professor of Neurology, who is focusing on mitochondrial encephalopathy with lactic acidosis and stroke-like episodes (MELAS), a progressive neurodegenerative disorder with limited treatment options that often causes diabetes. She is using brain imaging and in vitro glucose uptake assays to better understand how the disease develops.

Dr. Steven Kawut, Herbert Irving Assistant Professor of Clinical Medicine, who is examining the function of neurohormones in the disease process of pulmonary hypertension or high blood pressure in the circulation of the lungs. These hormones may be important predictors of disease development and prognosis indicators for people with pulmonary hypertension.

Dr. Judith Korner, Florence Irving Assistant Professor of Clinical Medicine, who is analyzing the effects of agents that target the melanocortin hormone and dopamine neurotransmitter pathways on body weight, appetite, and glucose and lipid metabolism in obese people without diabetes. She hopes to apply the results of the study to develop new ways to treat obesity in adults.

Dr. Michael G. Vitale, Herbert Irving Assistant Professor of Orthopedic Surgery, who is assessing quality of life of children with neuromuscular disorders and developing a disease-specific method to measure the population of these children. He also plans to develop a web-based registry to support multidisciplinary and multi-institutional patient care and clinical research for these children.

The Irving's support of patient-oriented research at Columbia has enabled the Irving Center to fund 57 Irving Scholars to date. Most of the past Irving Scholars remain as leaders of Columbia's clinical research community.

—Matthew Dougherty


Dean's Day for Medical Student Research offers students who perform research while at P&S the opportunity to make a poster presentation of their work. This year's event featured poster presentations from approximately 25 P&S students. Five students received prizes—awarded by the Gladys Brooks Foundation—for their work. The winners posed with Dr. Alfred Steiner, third from left, a longtime supporter of the Dean's Day event, and, second from right, Dr. Gerald D. Fischbach, executive vice president and dean. From left to right, the winners were (poster presentation titles in parentheses) Candice Chen ("Repeat Reliability of the Multifocal Visual Evoked Potential in Normal and Glaucomatous Eyes"), Christiana Iyasere ("Complete Suppression of Proliferation Despite Persistence of Virus-specific CD4+ T Cells During HIV Viremia"), Brian Parrett ("Adipose Tissue Engineering: Differentiation and Implantation of Fat-Derived Stem Cells in Lewis Rats"), Jing Wang ("A Novel Allosteric Model for Cyclic AMP Signaling in HCN Pacemaker Channels"), and Coral Omene ("Functional Characterization of the BRCA1/BARD1 Interaction").



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