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Disruption in Brain Connection Linked to Genetic Defect in Schizophrenia

Columbia researchers have illuminated how a genetic variant may lead to schizophrenia by causing a disruption in communication between the hippocampus and prefrontal cortex regions of the brain, areas believed to be responsible for carrying out working memory. Findings were published in Nature. The discovery coincides with the 15th anniversary of the first identification of the link between schizophrenia and a genetic mutation – a microdeletion on human chromosome 22 – known as 22q11 deletion, by Columbia researcher Maria Karayiorgou, M.D., a coauthor of the new research.

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