Brain Researcher Defies Conventional Wisdom on Estrogen

When Dominique Toran-Allerand, M.D., Sc.D., started studying the effects of estrogen in the brain some 40 years ago, her research was considered so unconventional as to be unbelievable. One of her first papers, she recalls, was met with a four-page single-spaced rejection letter from the Journal of Brain Research.

“There is a lot of dogma in science,” she said. “When you’re challenging dogma, it makes your work more difficult to prove.” Today, the estrogen-brain connection is an accepted part of neuroscience, and Dr. Toran-Allerand’s work is considered groundbreaking.

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