Lee Goldman: New EVP and P&S Dean
LEE GOLDMAN IS THE BEST CHAIRMAN OF MEDICINE THAT JAY LEVY, a 1965 P&S graduate, has had during his Lee Goldman: New EVP and P&S Dean35 years at the University of California, San Francisco. “I wish he had stayed here,” says Dr. Levy, “but if we can’t keep him, I’m glad he’s going to my alma mater. Columbia is very fortunate.”
     Dr. Goldman was introduced at Columbia University Medical Center in April as the next executive vice president for health and biomedical sciences and dean of the Faculties of Health Sciences and Medicine, succeeding Gerald D. Fischbach, who announced plans last year to step down by the end of June 2006. Dr. Goldman will assume his new Columbia posts July 1.
     Dr. Levy, director of the Laboratory for Tumor and AIDS Virus Research at UCSF, conducts research in infectious diseases, particularly AIDS, that bridges basic science and clinical medicine. He says Dr. Goldman “is not involved directly in basic science but he has great respect for basic research. That’s why it’s been such a pleasure to work with him. He has made great efforts to bring basic scientists and clinicians together to interact and share a common goal.”
     Dr. Levy and another P&S alumnus, Samuel Barondes, a 1958 graduate, shared their impressions of Dr. Goldman in telephone interviews.
     Dr. Levy, professor of medicine at UCSF, describes Dr. Goldman as “supportive and fair. When he arrived, he

Lee Goldman, M.D and his wifeLee Goldman, M.D., M.P.H.

Born: Philadelphia
B.A. Yale University, 1969
M.D. Yale University, 1973
M.P.H. Yale University, 1973

Intern in Medicine: UCSF
Junior Resident in Medicine: UCSF
Senior Resident in Medicine: Massachusetts General
Clinical Fellow in Medicine: Harvard Medical School
Fellow in Cardiology: Yale-New Haven Hospital

Faculty: Harvard Medical School, 1978-1995 (full professor
in 1989)
Faculty: Harvard School of Public Health, 1992-1995
Faculty: UCSF, 1995-2006

Member: American Society for Clinical Investigation, Association of American Physicians (president in 2001-2002), Institute of Medicine, elected fellow of the American Association for the Advancement of Science, Association of Professors of Medicine (current president)

Editorships: Former associate editor of the New England Journal of Medicine and editor of the American Journal of Medicine

Lead Editor: “Cecil Textbook of Medicine” (known formerly as the “Cecil-Loeb Textbook of Medicine,” co-edited from 1951 to 1959 by P&S legend Robert Loeb)

Known for: Goldman Index to assess cardiac risk involved in noncardiac surgeries, Goldman Criteria to determine which patients with chest pain require hospital admission, Coronary Heart Disease Policy Model to set priorities for the prevention and treatment of heart disease, and creation of first academic hospitalist program

Awards: The Glaser Award, the Society of General Internal Medicine’s highest honor; the Blake Award from the Association of American Physicians

Family: Wife Jill Goldman, a genetic counselor, and three grown children

quickly went out to meet the faculty and has let us know how much he appreciates our work. He acknowledges our receipt of grants or awards and truly makes people feel appreciated. His warm personality will certainly come through at Columbia which is gaining not only an effective leader but also a world-renowned physician, well-recognized for his studies in cardiology and in managed care. He and Columbia, working together, will make a great union.”
     Dr. Barondes, the Jeanne and Sanford Robertson Professor of Psychiatry and director of the Center for Neurobiology and Psychiatry at UCSF, has worked with Dr. Goldman on university committees and joint recruitment of faculty. “He is a very determined and effective leader,” says Dr. Barondes, former chairman of psychiatry at UCSF. “When he sets his mind to doing something, he gets it done.
     “He’ll move the school forward successfully,” adds Dr. Barondes, who has been at UCSF for 20 years.
     At UCSF, Dr. Goldman is chairman of medicine, the Julius R. Krevans Distinguished Professor, and associate dean for clinical affairs. Dr. Goldman took an outstanding Department of Medicine and built on its strengths, Dr. Barondes said. “Hopefully he can do the same at P&S.”
     UCSF is a health sciences campus of the University of California system. It has medical, nursing, pharmacy, dental, and biomedical graduate schools. It offers only graduate degrees, making it similar to the four schools and graduate program of CUMC. UCSF’s urban setting is also similar to CUMC’s, and its development of a Mission Bay campus has parallels to Columbia’s potential development in Manhattanville. “Lee will be familiar with those complex challenges,” says Dr. Barondes. “I think he’ll do an outstanding job.”
     Robert Fishman, professor emeritus and retired chairman of neurology at UCSF, describes Dr. Goldman as an effective cardiologist, department chairman, and editor – “who’s ready for a new challenge, the next step in his career.” Dr. Fishman, who was chief resident in neurology at Columbia and a P&S neurology faculty member until moving to UCSF in 1965, says Dr. Goldman “was extremely effective in building the Department of Medicine and well-respected for his judgment.” Of Dr. Goldman and his wife, a member of Dr. Fishman’s neurology faculty, Dr. Fishman says: “I think you’re lucky to get them.”
     Dr. Goldman, an internationally recognized expert in health outcomes research and public health, has M.D. and M.P.H. degrees from Yale. Columbia President Lee Bollinger chaired the search committee that put Dr. Goldman’s name on a short list of three finalists. President Bollinger made the final choice and introduced Dr. Goldman to the CUMC community at an April 10 Town Hall.
     Dr. Goldman will have appointments as the Harold and Margaret Hatch Professor of the University, professor of medicine in P&S, and professor of epidemiology in Columbia’s Mailman School of Public Health.
     The UCSF Department of Medicine, which Dr. Goldman has chaired since 1995, receives more financing in grants and contracts from the NIH than any other academic department of any kind in the United States. During Dr. Goldman’s 11 years as chairman, the department grew from about 325 to about 550 faculty, NIH funding tripled, and clinical care and teaching were reorganized and expanded.
     At Columbia, Dr. Goldman will be EVP and dean of the Faculties of the Health Sciences, which comprises P&S, the Mailman School of Public Health, the School of Nursing, the College of Dental Medicine, and the biomedical graduate program. He also will serve as dean of P&S.
     “The many people I’ve met at Columbia uniformly impress me with their commitment and their belief that this can be the best academic medical center,” says Dr. Goldman. “I am also impressed by everyone’s willingness to work tirelessly to make it the greatest place. No one wants anything less than the very best, and I’m proud to become part of that commitment.”
     Dr. Goldman is a pioneer in the application of statistical analysis to key areas of clinical medicine. He has developed innovative predictive models used by clinical investigators and practicing physicians, including the Goldman Index to assess cardiac risk from noncardiac surgeries, the Goldman Criteria to determine which patients with chest pain require hospital admission, and the Coronary Heart Disease Policy Model, which established priorities for preventing and treating coronary disease. In San Francisco, he created the first academic hospitalist program.
     Dr. Goldman, a cardiologist by training, served on the faculty at Harvard Medical School from 1978 until joining UCSF in 1995. At Harvard he was vice chairman of the Department of Medicine and later chief medical officer at Brigham & Women’s Hospital.
     Among his more than 400 publications are more than 20 first- or senior-authored articles in the New England Journal of Medicine. Many of those who trained under him are now leaders in cardiology, general internal medicine, and public health nationally and internationally. Dr. Goldman was a creator of the Harvard Program in Clinical Effectiveness, which was one of the models for an NIH program that trains physician investigators at academic medical centers throughout the country.
     Dr. Goldman’s wife, Jill S. Goldman, M.S., MPhil, is a clinician, educator, and researcher. She has been a genetic counselor in the UCSF Department of Neurology and an assistant clinical professor in the UCSF School of Nursing. She focuses on patient care and the research aspects of hereditary adult-onset neurological diseases, such as dementia and ALS. She has coordinated genetic research and genetic risk assessment and has taught nursing students specializing in genomics.

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Manhattanville: Largest Gift to Columbia Will Build Neuroscience Center
At the announcement of the Jerome L. Greene Science Center, from left, are Richard Axel, Eric Kandel, Tom Jessell, and Gerald Fischbach.
At the announcement of the Jerome L. Greene Science Center, from left, are Richard Axel, Eric Kandel, Tom Jessell, and Gerald Fischbach.
A GIFT ANNOUNCED IN MARCH WILL ESTABLISH THE JEROME L. Greene Science Center, a new research and teaching facility that will serve as the intellectual home for Columbia’s expanding initiative in Mind, Brain and Behavior. The gift from Dawn M. Greene and the Jerome L. Greene Foundation honors Mrs. Greene’s late husband, Jerome L. Greene, a graduate of Columbia College and Law School.
     Valued at more than $200 million, the gift is the largest ever received by Columbia University and the largest private gift received by any U.S. university for the creation of a single facility. The Greene Center will be led by the renowned neurobiologist Thomas Jessell and Nobel laureates Richard Axel and Eric Kandel.
     Columbia President Lee Bollinger announced the gift at a special event attended by Mrs. Greene, Columbia President Emeritus Michael Sovern, Congressman Charles B. Rangel, and New York City Mayor Michael R. Bloomberg.
     “The Jerome L. Greene Science Center, on our proposed Manhattanville campus, will forever symbolize our ongoing effort to understand the human organism. It will also, in very practical ways, lead to cures for diseases and a deeper grasp of our behavior as individuals and societies,” said Mr. Bollinger. “In so doing, the Jerome L. Greene Science Center will carry on the legacy of a great Columbian.”
     Mr. Greene, a prominent New York lawyer, real estate investor, and philanthropist who died in 1999, credited Columbia with providing him the foundation for his professional success. In addition to supporting other Columbia programs, the Greenes have made major gifts to the medical center, including the Jerome L. and Dawn Greene Infectious Disease Laboratory at the Mailman School of Public Health and endowment of the Jerome L. and Dawn Greene Professorship in Epidemiology.
     The Greene Center in Manhattanville will include laboratories in which Columbia scientists will explore the causal relationship between gene function, brain wiring, and behavior, research that has implications for the treatment of brain illness — probing the root causes of neurodegenerative diseases, such as Parkinson’s and Alzheimer’s diseases, and motor neuron diseases, for example. The research also will help decode disorders of mood and motivation, cognition and behavior, such as autism, dementia, and schizophrenia. The center will have an educational outreach facility and clinical programs with a focus on childhood developmental disorders and diseases of the aging brain. Through exploration of the brain’s organization and function, the center will aim to clarify the workings of the mind — the mental processes that permit us to perceive, act, learn and remember and govern the individuality of human action.
     “I know that Jerry would be as excited as the Foundation and I to be making this gift. He believed in education, especially a Columbia education, and he believed in New York and its future,” said Dawn Greene, president and CEO of the Jerome L. Greene Foundation. “Columbia’s plans for development north of the Morningside campus reflect Jerry’s devotion to continually improving our city and to expanding educational and research opportunities through the institutions he cared most about. The creation of a building for the Mind, Brain and Behavior Initiative struck me as the perfect coming together of all of his interests. I am thrilled that we are able to do this.”
     The center’s location in the new campus in West Harlem is subject to completion of the appropriate public processes that will allow development of Manhattanville between the Morningside Heights and medical center campuses.
     Recent neuroscience initiatives at Columbia include the Kavli Institute for Brain Science, the Gatsby Initiative in Brain Circuitry, the Columbia Motor Neuron Center, and the Center for Theoretical Neuroscience. The efforts are coordinated by the Columbia University Center for Neuroscience Initiatives (www.columbiacni.org).
     “Our generation of scientists has come to believe that the biology of the mind will be as important scientifically to the 21st century as the biology of the gene was for the 20th century,” said Dr. Kandel, University Professor and 2000 Nobel Laureate. “We therefore view the establishment of the Jerome L. Greene Science Center as a major step forward for the study of the science, brain, and mind, both at Columbia and nationally. In addition to assuring that Columbia retains national leadership in the neurosciences, the new initiative in mind, brain, and behavior within the center will attempt to bridge the sciences concerned with the natural world with the meaning of human experience. Insights that come from this new synthesis will not only improve our understanding of psychiatric and neurological disorders, but will also lead to a deeper understanding of ourselves, by bridging the biology of mind to other areas of knowledge — philosophy, psychology, sociology, economics and education.”
     Research conducted within the center will provide an opportunity to link research in the neurosciences to Columbia’s existing strengths in other scientific disciplines. The center will have a catalytic role in forging closer ties between the brain sciences, the programs of the business and law schools, and the many disciplines of the arts, humanities, and social sciences. Through the integration of these programs, the Jerome L. Greene Science Center will ensure Columbia’s continued leadership in the modern study of the brain and mind.

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News in Brief
STEPHEN P. GOFF, PH.DSTEPHEN P. GOFF, PH.D, a researcher known for his groundbreaking work in improving our understanding of retroviruses, has been elected to the National Academy of Sciences. Dr. Goff is the Higgins Professor of Biochemistry and Molecular Biophysics, professor of microbiology, and Howard Hughes Medical Institute investigator. ... The Spinal Muscular Atrophy Foundation has given Columbia a grant of up to $15 million to fund activities by Columbia’s new CENTER FOR MOTOR NEURON BIOLOGY AND DISEASE. The effort is intended to accelerate the discovery of medical advances for SMA, the No. 1 genetic killer of infants and toddlers. The Center for Motor Neuron Biology and Disease (www.ColumbiaMNC.org) was founded at Columbia University in November 2005. It is a unique research center committed to focusing on the biology of the motor neuron and two diseases caused by motor neuron degeneration: SMA and amyotrophic lateral sclerosis. Its mission is to create a cohesive translational research center where laboratory findings are quickly translated into new treatments for patients, and clinical observations are regularly brought into the laboratory to shape new directions in research. The center includes more than 40 leading researchers from numerous disciplines at CUMC and Columbia’s Morningside campus. As part of the grant agreement, the center will recruit new investigators to complement existing Columbia expertise. The gift, to be distributed over five years, is the largest ever made by a private foundation for SMA research. ... Beginning in August 2006, a new two-year EXECUTIVE MASTER OF SCIENCE DEGREE IN BIOMEDICAL INFORMATICS will be offered at CUMC. The program is designed for working health care professionals, especially physicians, nurses and department managers, who wish to enhance their knowledge of information systems and biomedicine. The curriculum includes an overview of information science and its relevance to biomedicine; the organization and management of biomedical data by computers; the characteristics of patient data; information systems for supporting and managing patient care; medical knowledge, clinical decision-making and decision support; information systems for health systems, hospitals, acute care facilities, long-term care facilities, ambulatory care centers, and clinical office practices; information systems, national policy, and the public health; A photo book that documents Columbia’s and clinical research methods in biomedical informatics. ... A photo book that documents Columbia’s medical center from 1928 to 2003 is available from Communications & External Relations, the office that produces P&S Journal. The book, “75 YEARS OF HEALING ON THE HEIGHTS,” was mailed to alumni in 2003 directly from a book distributor. Many alumni returned the book unopened, perhaps thinking it was an unsolicited book club selection. To get a copy of the book, send a request by e-mail to cumcnews@columbia.edu or write to Communications & External Relations, 701 W. 168th St., Suite 206, New York, NY 10032. The book is available without charge while supplies last.



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NY-Presbyterian Breaks Ground for Heart Hospital
An architectural rendering of the Milstein Family Heart Center, looking northeast from the intersection of Riverside Drive and 165th Street.
An architectural rendering of the Milstein Family Heart Center, looking northeast from the intersection of Riverside Drive and 165th Street.

CONSTRUCTION HAS BEGUN ON THE 142,000-SQUARE-FOOT Vivian and Seymour Milstein Family Heart Center for New York-Presbyterian Hospital/Columbia University Medical Center. Former President Bill Clinton attended the April 27 groundbreaking. The building, to be located between the Milstein Hospital Building and the Herbert Irving Pavilion (formerly the Dana Atchley Pavilion), is expected to be completed in 2009.
     The six-story Heart Center is supported by a $50 million gift from the Vivian and Seymour Milstein family foundations. It is the largest single gift in the hospital’s history.
     The facility’s comprehensive heart care services, coupled with world-renowned physicians, will make it one of the world’s top heart care centers. Patients will have access to the most advanced diagnostic technology and treatments that are frequently less invasive and more accurate and require less healing time.
     Herbert Pardes, M.D., president and CEO of New York-Presbyterian Hospital, said, “Our new Heart Center will help to forge a new era in medicine, offering patients access to care with expanded ambulatory, cardiology, and diagnostic services. By moving diagnosis and treatment under one roof, we will increase efficiency and convenience for all of our patients from New York and around the world. The new center also allows us to increase our capacity for superb outpatient care, which is a growing trend as we strengthen minimally invasive approaches to heart care.”
     “We are enormously pleased and proud to continue the association that my late husband, Seymour, and I have enjoyed with this great hospital for more than half a century,” said Vivian Leiner Milstein, who spoke also on behalf of her daughter, Connie, and son, Philip. “We are thrilled to be able to realize the vision of creating the Vivian and Seymour Milstein Family Heart Center, which will serve as a wonderful home for the entire team of world class cardiologists and cardiothoracic surgeons that make New York-Presbyterian/Columbia a preeminent hospital for cardiac care.”
     Allan Schwartz, M.D., a 1974 P&S graduate who is chief of cardiology at P&S and New York-Presbyterian Hospital, also participated in the groundbreaking. “The Heart Center will allow New York-Presbyterian Hospital to continue on its innovative path — a road that saw this hospital perform the first successful pediatric heart transplant operation, the first robotically assisted open heart procedure, and the first endoscopic coronary artery bypass surgery in the country along with many other breakthroughs in cardiovascular research and patient care.”
     The new Heart Center will have experts in coronary artery disease, electrophysiology for the study and treatment of arrhythmia, and surgical and nonsurgical treatments for heart failure, including heart transplantation; will provide nonsurgical alternatives through interventional cardiology and for development of nonsurgical procedures for conditions that previously required complicated and high-risk surgery; and will facilitate collaboration between basic science and clinical researchers in an environment that will translate scientific discoveries into bedside applications. Even though the facility will be free-standing with its own entrance on Fort Washington Avenue, the building will connect to the Irving Pavilion on five levels, including the lobby, and to Milstein on all six levels, including the lobby.

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