Clinical and Translational Research
- Role of Autophagy in Kidney Disease Autophagy is a fundamental biological process for normal function and stress response in animals and plants. The importance of autophagy has been well-recognized by winning Nobel Prize in 2016 by Dr. Yoshinori Ohsumi. Autophagy plays a critical role in the kidney. Research in the laboratory of Dr. Fangming Lin has shown that following urinary tract obstruction or ischemic injury to the kidney, autophagy in renal tubules is activated in a dynamic fashion. Furthermore, autophagic activity is regulated by a stress-responsive transcription factor FoxO3 and dysregulation of autophagy results in the development and progression of chronic kidney disease. Current research focuses on experimental animal studies to understand the mechanism of autophagy regulation with the goal to help design methods that integrate modulation of autophagy into prevention and treatment for kidney disease. This project is funded by the National Institutes of Health, DK107653, 2016-2019 to Fangming Lin, MD, PhD.
- Parthenogenesis of Chronic Kidney Disease in Children with Premature Birth Premature infants are born with under-developed kidney and have a high incidence of acute kidney injury (AKI) during the neonatal period, putting them at risk for developing chronic kidney disease (CKD). We study the pathogenesis of AKI to CKD transition in under-developed kidneys using mouse models of low nephron numbers created by genetic and pharmacological approaches. This project has been awarded to Dr. Pamela Good who is co-mentored by Drs. Fangming Lin and Frank Costantini under the Pediatric Scientist Development Program (NICHD/Cincinnati Children’s Hospital), July 2018-June 2020.
- Advancing Clinical Research in Primary Glomerular Disease The Division of Pediatric Nephrology collaborates with the Division of Nephrology in Internal Medicine at Columbia University and participates in the multicenter cohort study of children and adults with glomerular diseases that include minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), membranous nephropathy (MN), and IgA nephropathy (IgAN). The study is funded by the National Institutes of Health, UM1DK100876, 2013-2018 (PI: Ali Gharavi, MD; Fangming Lin, MD, PhD, co-investigator).
- Genomics of IgA-related Disorders in Kids Study (GIGA Kids) The Division of Pediatric Nephrology participates in the multicenter collaborative study based at Columbia University and sponsored by the Midwest Pediatric Nephrology Consortium (MWPNC). The study aims to recruit over 1,000 children with IgA nephropathy or Henoch-Schönlein purpura (with or without nephritis) for the purpose of genetic, genomic and biomarker studies. PI: Krysztof Kiryluk, MD, private funding, project ongoing.