Clinical and Translational Research
- Stem Cell Therapy for Acute Kidney Injury This project combines stem cell biology with translational research to investigate the potential of using stem cells to treat acute kidney injury. The future goal is to develop safe and effective treatments for human kidney disease. (NIH/NIDDK, R01DK083411). Fangming Lin, MD, PhD
- The Pediatric Hypertension Outcome Measures Study This is a multicenter collaboration aimed at identifying the epidemiologic, molecular and genetic mechanisms of pediatric hypertension and the precursors of adult cardiovascular disease. Robert Woroniecki, MD
- Morphologic biomarkers of response to therapy in nephrotic syndrome: To examine the association between the degree of podocyte foot process effacement and immunosuppressive treatment outcomes (response vs. partial response/no-response) in collaboration with NIH-sponsored Nephrotic Syndrome Study Network (NEPTUNE) Longitudinal Cohort study. Robert Woroniecki, MD
- Association of apolipoprotein-1 (APOL1) genetic variants with renal disease progression and cardiovascular morbidity in African Americans: An NIH multi-institutional trial to evaluate uncontrolled hypertension and the development of chronic kidney disease. Robert Woroniecki, MD
- Role of Autophagy in Kidney Tubular Atrophy Urinary tract obstruction during kidney development can result in kidney malformations, kidney tubular atrophy and renal failure. The aim of this study is to test whether autophagy (self-eating of the cell) plays a role in obstruction-induced tubular atrophy in mouse models. Understanding the mechanism of tubular atrophy will guide our future development of strategies to prevent and/or slow down the progression of chronic kidney disease. (March of Dimes Research Grant, 6-FY11-311). Fangming Lin, MD, PhD
- Phenotype-genotype Correlations in Congenital Aanomalies of the Kidney and Urinary Tract (CAKUT) This project is to study the entire spectrum of CAKUT and gain insights into phenotype-genotype correlations, prognostic factors and the possibility of developing better and less invasive diagnostic tests. Patricia Weng, MD