Molecular Genetics

Faculty

Rudolph Leibel, MD

Academic Title(s):

Christopher J. Murphy Memorial Professor of Diabetes Research
Professor of Pediatrics
Director, Division of Molecular Genetics
Co-Director, Naomi Berrie Diabetes Center

Contact Information:

Tel: (212) 851-5257
Fax: (212) 851-5306
Email: RL232@columbia.edu

Education

  • Colgate University, A.B., 1963
  • Albert Einstein College of Medicine, M.D., 1967

Postgraduate Training

  • Intern and junior resident in Pediatrics, Massachusetts General Hospital, 1967-1969 Senior Resident in Medicine, Children's Hospital Medical Center, Boston, 1971-1972
  • NIH Clinical and Research Fellow in Pediatric Endocrinology Metabolism, Massachusetts General Hospital, 1972-1974

Interests/Specialties

  • Obesity
  • Type 2 Diabetes
  • Disorders of Growth

learn more about Dr. Leibel

Dr. Leibel has worked in obesity research for over 25 years. His research has related to adipose tissue biochemistry and cellular physiology, the molecular genetics of control of body weight in rodents and humans, the bioenergetics of body weight regulation in humans and the role of leptin in these processes, and the molecular genetics of type 2 diabetes. He and his associates conduct studies in both rodents and humans, and have recently undertaken collaborative experiments designed to create disease-related cells and tissues from human embryonal stem cells. He is a member of the Institute of Medicine of the National Academy of Sciences, and has recently served as a member of the Federal Advisory Council for NIDDK and as an Associate Editor of the Journal of Clinical Investigation.

Click here to view Dr. Leibel's CV in PDF format.

Click here to review Dr. Leibel's publications.

Wendy Chung, MD, PhD

Academic Title(s):

Kennedy Family Associate Professor with Tenure, Department of Pediatrics in Medicine

Director, Clinical Genetics, Columbia University Medical Center
Director, Clinical Cancer Genetics, Columbia University Medical Center
Director, DISCOVER Program
 

Contact Information:

Tel: (212) 851-5313
Fax: (212) 851-5306
Email: wkc15@columbia.edu

Education

  • Cornell University, B.A., 1990
  • Rockefeller University, Ph.D., 1996
  • Cornell University, M.D., 1998

Postgraduate Training

  • Intern and resident in Pediatrics, Columbia Presbyterian Medical Center, 1998-2000
  • Fellow, Clinical Genetics, Division of Clinical Genetics in Pediatrics, Columbia Presbyterian Medical Center, 2000-2002
  • Fellow, Molecular Genetics, Division of Clinical Genetics in Pediatrics, Columbia Presbyterian Medical Center, 2002-2003

Awards and Honors:

  • Westinghouse Science Talent Search, first place; National Merit Scholar,1985
  • Cornell Scholar; Dean’s List, 1986-1990
  • Phi Beta Kappa; Outstanding College Students of America; Phi Kappa Phi; Golden Key Honor Society; The National Dean’s List, 1990
  • American Institute of Nutrition, Outstanding Student Research Award, 1992
  • Louis Gibofsky Memorial Prize, Cornell University Medical College, 1994
  • Dean’s Research Award, Cornell University Medical College, 1995
  • Dean’s Research Award, Cornell University Medical College, 1998
  • Young Investigator Research Grant Award, American Academy of Pediatrics, 2001
  • Herbert Irving Scholar, 2004
  • American Medical Women’s Association Mentor Award, 2005
  • Doris Duke Clinical Scientist Development Award, 2007
  • Charles W. Bohmfalk Award for Teaching in the Clinical Years, 2008
  • Presidential Award for Outstanding Teaching, Columbia University, 2009
  • Dade County Hall of Fame, 2012
  • Dean’s Distinguished Lecture in the Clinical Sciences, 2014
  • Science Unbound Foundation’s Best Paper for 2013, 2014
  • American Society for Clinical Investigation, 2015

Interests/Specialties

  • Genetic basis of obesity and diabetes
  • Inborn errors of metabolism
  • Congenital heart disease and cardiomyopathies
  • Metabolic disease
  • Breast and pancreatic cancer susceptibility
  • Birth defects
  • Cardiac disease
  • Spinal Muscular Atrophy
  • Autism and neurodevelopmental disorders
  • Ethical legal and social implications of genomics
  • Genomic medicine integration
  • Precision medicine
  • Rare cancer syndromes
  • Implementation of clinical testing for common cancers

Learn more about Dr. Chung

Dr. Chung is the Kennedy Family Associate Professor of Pediatrics in Medicine and is board certified by the American Board of Medical Genetics in clinical and molecular geneticist with 20 years of experience in human genetic research of monogenic and complex traits including diseases such as congenital heart disease, whose genetic research of monogenic and complex traits including diseases such as congenital heart disease, pulmonary hypertension, inherited arrhythmias, cardiomyopathies, breast cancer, pancreatic cancer, obesity, diabetes, congenital heart disease, congenital diaphragmatic hernias, and autism. She has extensive experience mapping and cloning genes in humans and mice using methods of linkage analysis, association studies, comparative genomic hybridization, and whole exome/genome sequencing and RNAseq. She also has extensive experience describing the clinical characteristics of novel genetic conditions and characterizing the spectrum of disease. She runs the molecular core of the New York Obesity Research Network, and she is also director of the Clinical Genetics Program, Clinical Cancer Genetics program, the DISCOVER program, and supervises medical education in human genetics for Columbia University Medical School.

Click here to review Dr. Chung's publications.

Michael Rosenbaum, MD

Academic Title(s):

Professor of Pediatrics and Medicine at CUMC

Contact Information:

Tel: (212) 305-9949
Fax: (212) 851-5306
Email: mr475@columbia.edu

Education

  • Amherst College, B.A., 1978
  • Cornell University Medical College, M.D., 1982

Postgraduate Training

  • Intern and resident in pediatrics, Columbia Presbyterian Medical Center, 1982-1985
  • Fellow, Division of Pediatric Endocrinology, The New York Hospital, 1985-1988

Interests/Specialties

  • Body weight regulation
  • Diabetes pathophysiology
  • Growth and nutrition
  • Preventive Medicine

Learn more about Dr. Rosenbaum

Dr. Rosenbaum is a Professor of Clinical Pediatrics and Clinical Medicine at Columbia Presbyterian Medical Center. He is the author of over 60 peer-reviewed manuscripts and chapters which reflect his primary interests in body weight regulation and pediatric type 2 diabetes mellitus. As a result of the significance of his work on the co-epidemics of obesity and diabetes, he is an internationally invited speaker at major scientific conferences and institutions. He is a co-Principal Investigator with Dr. Rudolph Leibel in an NIH-funded clinical study regarding the roles of leptin and thyroid hormones in the metabolic, neuroendocrine, and autonomic changes that accompany attempts to maintain a reduced body weight. In addition, Dr. Rosenbaum has led studies of the pathophysiolgy and prevention of type 2 diabetes in children. Following the completion of pilot studies demonstrating the relative heritability of various pre-diabetic traits and the influence of a supervised exercise and nutritional and health education on these risk factors in children, Dr. Rosenbaum received an AMDeC/Starr Foundation grant to continue these school-based studies longitudinally and in multiple ethnic groups, as well as to begin to examine the molecular genetics of type 2 diabetes in children. He is co-Principal Investigator on this project with Dr. Steven Shelov at Maimonides Medical Center. Dr. Rosenbaum has mentored multiple research fellows and currently serves as a mentor on two NIH-funded young investigator awards. One of these awards examines the metabolomics of individuals with subarachnoid hemorrhage and the other studies periodontal disease as a risk factor for type 2 diabetes. Dr. Rosenbaum meets regularly with house officers from the department of medicine during their clinical research rotations and is a regular lecturer to medical students, students at the Institute for Human Nutrition, and masters students in patient-oriented research and in biostatistics. He is board certified in General Pediatrics and in Pediatric Endocrinology.

Click here to review Dr. Rosenbaum's publications.

Charles LeDuc, PhD

Academic Title(s):

Associate Research Scientist

Contact Information:

Tel: (212) 851-5311
Fax: (212) 851-5306
Email: CAL8@columbia.edu

Education

  • Cornell University, B.S., 1990
  • Columbia University, Ph.D., 1995

Interests/Specialties

  • Obesity
  • Type 2 Diabetes
  • Genetic Technologies

Learn more about Dr. LeDuc

Dr. LeDuc is a research scientist at Columbia University Medical Center in the Division of Molecular Genetics in the Department of Pediatrics.

Dr. LeDuc has worked in obesity research for over 10 years. His research attempts to determine the genetic and biochemical basis of the control of body weight, insulin production and glucose homeostasis in rodents and humans. The role of leptin in these processes, and the molecular genetics of type 2 diabetes. He conducts studies primarily in rodent models of obesity and in cell culture to understand these conditions. Dr. LeDuc has extensive experience in advanced genetic technologies; expression, SNP, and copy number arrays.

Click here to review Dr. LeDuc's publications.

Lijiang Ma, PhD

Academic Title(s):

Associate Research Scientist

Contact Information:

Email: lm2689@columbia.edu

Education

  • Medical Sciences, China 1999
  • Texas A&M University, Ph.D., 2005
  • MD Anderson, 2006-2008

Postgraduate Training

  • Texas A&M University 2005-2006
  • MD Anderson, 2006-2008

Interests/Specialties

  • Novel genes for congenital diaphragmatic hernia 

Click here to review Dr. Ma's publications.

Linshan Shang, PhD

Academic Title(s):

Associate Research Scientist

Contact Information:

Tel: (212) 851-5311
Fax: (212) 851-5306
Email: ls2683@cumc.columbia.edu

Education

  • Qufu Normal University, China, B.S., 2000
  • Shandong University, China, M.S., 2003
  • Shandong University, China, Ph.D., 2007

Postgraduate Training

  • Postdoctoral Research Scientist, Columbia University, 2007-2010
  • Postdoctoral Research Scientist, The New York Stem Cell Foundation, 2010-2013

Interests/Specialties

  • Stem cell research
  • Diabetes
  • Genetic studies of congenital diaphragmatic hernia

Learn more about Dr. Shang

Dr. Shang is an associate research scientist in the Division of Molecular Genetics, Department of Pediatrics. Her research is focused on disease etiology identification of congenital diaphragmatic hernia using next-generation sequencing technology; and disease causing mechanism studies using animal models.

Click here to review Dr. Shang's publications.

George Stratigopoulos, PhD

Academic Title(s):

Associate Research Scientist

Contact Information:

Tel: (212) 851-5309
Fax: (212) 851-5306
Email: GS2172@columbia.edu

Education

  • University of Glasgow, BSc., 1998
  • University of Leicester, Ph.D., 2002

Postgraduate Training

  • Postdoctoral Research Training, Genetics & Development, Columbia University, NY, 2004-2006
  • Postdoctoral Research Training, Department of Pediatrics, Division of Molecular Genetics, Columbia University, 2006-2008

Interests/Specialties

  • FTO-associated obesity
  • Primary cilia and obesity

Learn more about Dr. Stratigopoulos

Dr. Stratigopoulos’s primary focus is to elucidate the molecular mechanisms underlying the strongest common genetic contributor to human obesity, the FTO locus. His research interests include the function of primary cilia in energy homeostasis, and in particular ciliary component RPGRIP1L encoded by a gene vicinal to the FTO locus that may contribute to the obesogenic signal at the FTO genetic site.

Click here to review Dr. Stratigopoulos's publications.

Yiying Zhang, PhD

Academic Title(s):

Research Scientist

Contact Information:

Tel: (212) 851-5301
Fax: (212) 851-5306
Email: yz84@columbia.edu

Education

  • Fudan University, China, B.S, 1982
  • New York University, Ph.D. 1992

Postgraduate Training

  • Postdoctoral Research Associate, Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockefeller University, NY, 1992-1995
  • Postdoctoral Fellow; Laboratory of Human Behavior and Metabolism; Rockefeller University, NY, 1995-1997

Interests/Specialties

  • Obesity
  • Type 2 diabetes
  • Adipose tissue biology

Learn more about Dr. Zhang

Dr. Zhang is a Research Scientist in the Division of Molecular Genetics, Department of Pediatrics. She has worked in obesity research for over 15 years. Her work has related to molecular cloning of the mouse obese (leptin) gene, regulation of leptin and the leptin receptor expression, adipose tissue physiology and biogenesis, nutrient sensing and dietary intervention. The research in Dr. Zhang�s laboratory involves primarily cellular and rodent animal models.

Click here to review Dr. Zhang's publications.

Stuart Fischer, PhD

Academic Title(s):

Special Research Scientist

Contact Information:

Tel: (212) 851-5304
Fax: (212) 851-5306
Email: sgf2@columbia.edu

Education

  • University of Chicago, B.S.
  • Princeton University, Ph.D.

Postgraduate Training

  • SUNY Albany, Albany, NY Post-Doc in Biology, 1976-1983

Interests/Specialties

  • Genomics
  • Bio-informatics/Computational biology
  • Diabetes/Obesity

Learn more about Dr. Fischer

Dr. Fischer is a Special Research Scientist, who co-developed well-known wet-lab methodologies in both protein and DNA analysis. He develops and implements computational strategies to identify and analyze genes and gene products mediating susceptibility to type 2 diabetes in the context of obesity. His role is to assist and guide affiliated experimental biologists through bio-informatics.

Click here to review Dr. Fischer's publications.