Molecular Genetics

Faculty

Rudolph Leibel, MD

Academic Title(s):

Christopher J. Murphy Memorial Professor of Diabetes Research
Professor of Pediatrics
Director, Division of Molecular Genetics
Co-Director, Naomi Berrie Diabetes Center

Contact Information:

Tel: (212) 851-5257
Fax: (212) 851-5306
Email: RL232@columbia.edu

Education

  • Colgate University, A.B., 1963
  • Albert Einstein College of Medicine, M.D., 1967

Postgraduate Training

  • Intern and junior resident in Pediatrics, Massachusetts General Hospital, 1967-1969 Senior Resident in Medicine, Children's Hospital Medical Center, Boston, 1971-1972
  • NIH Clinical and Research Fellow in Pediatric Endocrinology Metabolism, Massachusetts General Hospital, 1972-1974

Interests/Specialties

  • Obesity
  • Type 2 Diabetes
  • Disorders of Growth

learn more about Dr. Leibel

Dr. Leibel has worked in obesity research for over 25 years. His research has related to adipose tissue biochemistry and cellular physiology, the molecular genetics of control of body weight in rodents and humans, the bioenergetics of body weight regulation in humans and the role of leptin in these processes, and the molecular genetics of type 2 diabetes. He and his associates conduct studies in both rodents and humans, and have recently undertaken collaborative experiments designed to create disease-related cells and tissues from human embryonal stem cells. He is a member of the Institute of Medicine of the National Academy of Sciences, and has recently served as a member of the Federal Advisory Council for NIDDK and as an Associate Editor of the Journal of Clinical Investigation.

Click here to view Dr. Leibel's CV in PDF format.

Click here to review Dr. Leibel's publications.

Wendy Chung, MD, PhD

Academic Title(s):

Associate Professor of Pediatrics (in Medicine)

Contact Information:

Tel: (212) 851-5313
Fax: (212) 851-5306
Email: wkc15@columbia.edu

Education

  • Cornell University, B.A., 1990
  • Rockefeller University, Ph.D., 1996
  • Cornell University, M.D., 1998

Postgraduate Training

  • Intern and resident in Pediatrics, Columbia Presbyterian Medical Center, 1998-2000
  • Fellow, Clinical Genetics, Division of Clinical Genetics in Pediatrics, Columbia Presbyterian Medical Center, 2000-2002
  • Fellow, Molecular Genetics, Division of Clinical Genetics in Pediatrics, Columbia Presbyterian Medical Center, 2002-2003

Awards and Honors

  • American Academy of Pediatrics Young Investigator Award
  • Charles W. Bohmfalk Award for Distinguished Contributions to Teaching in the Clinical Years.

Interests/Specialties

  • Genetic basis of obesity and diabetes
  • Congenital heart disease and cardiomyopathies
  • Metabolic disease
  • Breast and pancreatic cancer susceptibility

Learn more about Dr. Chung

Dr. Chung is a Herbert Irving Assistant Professor of pediatrics in medicine whose research relates to the molecular genetics of obesity and diabetes in rodents and humans, the genetic basis of congenital heart disease, cardiomyopathies, arrhythmias, long QT Syndrome, pulmonary hypertension, endocrinopathies, congenital diaphragmatic hernias, cleft lip/cleft palate, seizures, mental retardation, inherited metabolic conditions and breast and pancreatic cancer susceptibility. She is the director of the Pediatric Heart Network Genetic Core, the Pediatric Neuromuscular Network Molecular Core, the New York Obesity Center Molecular Genetics Core and the Diabetes and Endocrine Research Center Molecular Genetics Core. She is also director of the Clinical Genetics Program, Clinical Cancer Genetics program, the director of the fellowship program in Cytogenetics and Molecular Genetics, and supervises medical education in human genetics for Columbia University Medical School.

Click here to review Dr. Chung's publications.

Michael Rosenbaum, MD

Academic Title(s):

Professor of Pediatrics and Medicine at CUMC

Contact Information:

Tel: (212) 305-9949
Fax: (212) 851-5306
Email: mr475@columbia.edu

Education

  • Amherst College, B.A., 1978
  • Cornell University Medical College, M.D., 1982

Postgraduate Training

  • Intern and resident in pediatrics, Columbia Presbyterian Medical Center, 1982-1985
  • Fellow, Division of Pediatric Endocrinology, The New York Hospital, 1985-1988

Interests/Specialties

  • Body weight regulation
  • Diabetes pathophysiology
  • Growth and nutrition
  • Preventive Medicine

Learn more about Dr. Rosenbaum

Dr. Rosenbaum is a Professor of Clinical Pediatrics and Clinical Medicine at Columbia Presbyterian Medical Center. He is the author of over 60 peer-reviewed manuscripts and chapters which reflect his primary interests in body weight regulation and pediatric type 2 diabetes mellitus. As a result of the significance of his work on the co-epidemics of obesity and diabetes, he is an internationally invited speaker at major scientific conferences and institutions. He is a co-Principal Investigator with Dr. Rudolph Leibel in an NIH-funded clinical study regarding the roles of leptin and thyroid hormones in the metabolic, neuroendocrine, and autonomic changes that accompany attempts to maintain a reduced body weight. In addition, Dr. Rosenbaum has led studies of the pathophysiolgy and prevention of type 2 diabetes in children. Following the completion of pilot studies demonstrating the relative heritability of various pre-diabetic traits and the influence of a supervised exercise and nutritional and health education on these risk factors in children, Dr. Rosenbaum received an AMDeC/Starr Foundation grant to continue these school-based studies longitudinally and in multiple ethnic groups, as well as to begin to examine the molecular genetics of type 2 diabetes in children. He is co-Principal Investigator on this project with Dr. Steven Shelov at Maimonides Medical Center. Dr. Rosenbaum has mentored multiple research fellows and currently serves as a mentor on two NIH-funded young investigator awards. One of these awards examines the metabolomics of individuals with subarachnoid hemorrhage and the other studies periodontal disease as a risk factor for type 2 diabetes. Dr. Rosenbaum meets regularly with house officers from the department of medicine during their clinical research rotations and is a regular lecturer to medical students, students at the Institute for Human Nutrition, and masters students in patient-oriented research and in biostatistics. He is board certified in General Pediatrics and in Pediatric Endocrinology.

Click here to review Dr. Rosenbaum's publications.

Charles LeDuc, PhD

Academic Title(s):

Associate Research Scientist

Contact Information:

Tel: (212) 851-5311
Fax: (212) 851-5306
Email: CAL8@columbia.edu

Education

  • Cornell University, B.S., 1990
  • Columbia University, Ph.D., 1995

Interests/Specialties

  • Obesity
  • Type 2 Diabetes
  • Genetic Technologies

Learn more about Dr. LeDuc

Dr. LeDuc is a research scientist at Columbia University Medical Center in the Division of Molecular Genetics in the Department of Pediatrics.

Dr. LeDuc has worked in obesity research for over 10 years. His research attempts to determine the genetic and biochemical basis of the control of body weight, insulin production and glucose homeostasis in rodents and humans. The role of leptin in these processes, and the molecular genetics of type 2 diabetes. He conducts studies primarily in rodent models of obesity and in cell culture to understand these conditions. Dr. LeDuc has extensive experience in advanced genetic technologies; expression, SNP, and copy number arrays.

Click here to review Dr. LeDuc's publications.

George Stratigopoulos, PhD

Academic Title(s):

Associate Research Scientist

Contact Information:

Tel: (212) 851-5309
Fax: (212) 851-5306
Email: GS2172@columbia.edu

Education

  • University of Glasgow, BSc., 1998
  • University of Leicester, Ph.D., 2002

Postgraduate Training

  • Postdoctoral Research Training, Genetics & Development, Columbia University, NY, 2004-2006
  • Postdoctoral Research Training, Department of Pediatrics, Division of Molecular Genetics, Columbia University, 2006-2008

Interests/Specialties

  • Obesity
  • Spinal Muscular Atrophy

Learn more about Dr. Stratigopoulos

Dr. Stratigopoulos is an associate research scientist in the Division of Molecular Genetics. His research is focused on elucidating the role of FTO and FTM genes in energy homeostasis and spinal muscular atrophy in both rodents and humans.

Click here to review Dr. Stratigopoulos's publications.

Yiying Zhang, PhD

Academic Title(s):

Research Scientist

Contact Information:

Tel: (212) 851-5301
Fax: (212) 851-5306
Email: yz84@columbia.edu

Education

  • Fudan University, China, B.S, 1982
  • New York University, Ph.D. 1992

Postgraduate Training

  • Postdoctoral Research Associate, Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockefeller University, NY, 1992-1995
  • Postdoctoral Fellow; Laboratory of Human Behavior and Metabolism; Rockefeller University, NY, 1995-1997

Interests/Specialties

  • Obesity
  • Type 2 diabetes
  • Adipose tissue biology

Learn more about Dr. Zhang

Dr. Zhang is a Research Scientist in the Division of Molecular Genetics, Department of Pediatrics. She has worked in obesity research for over 15 years. Her work has related to molecular cloning of the mouse obese (leptin) gene, regulation of leptin and the leptin receptor expression, adipose tissue physiology and biogenesis, nutrient sensing and dietary intervention. The research in Dr. Zhang�s laboratory involves primarily cellular and rodent animal models.

Click here to review Dr. Zhang's publications.

Stuart Fischer, PhD

Academic Title(s):

Special Research Scientist

Contact Information:

Tel: (212) 851-5304
Fax: (212) 851-5306
Email: sgf2@columbia.edu

Education

  • University of Chicago, B.S.
  • Princeton University, Ph.D.

Postgraduate Training

  • SUNY Albany, Albany, NY Post-Doc in Biology, 1976-1983

Interests/Specialties

  • Genomics
  • Bio-informatics/Computational biology
  • Diabetes/Obesity

Learn more about Dr. Fischer

Dr. Fischer is a Special Research Scientist, who co-developed well-known wet-lab methodologies in both protein and DNA analysis. He develops and implements computational strategies to identify and analyze genes and gene products mediating susceptibility to type 2 diabetes in the context of obesity. His role is to assist and guide affiliated experimental biologists through bio-informatics.

Click here to review Dr. Fischer's publications.

Lan Yu, PhD

Academic Title(s):

Associate Research Scientist

Contact Information:

Tel: (212) 851-5318
Fax: (212) 851-5306
Email: ly2255@columbia.edu

Education

  • Minzu University of China, B.S., 2001
  • Institute for Nutritional Sciences, Chinese Academy of Sciences, Ph.D., 2006

Postgraduate Training

  • Postdoctoral Fellow, Department of Psychiatry, Johns Hopkins University, 2008-2010

Interests/Specialties

  • Human genome structural variations
  • Genetic studies of congenital diaphragmatic hernia
  • High throughput genomics
  • Psychiatric disorders

Learn more about Dr. Yu

Dr. Yu is an associate Research Scientist in the Division of Molecular Genetics, Department of Pediatrics. Her research has focused on the genetic studies of human mendelian and complex diseases, using state-of-the art genomic technologies. Her current work is to identify the novel genetic markers, investigate the copy number changes in congenital diaphragmatic hernia.

Click here to review Dr. Yu's publications.