Hematology, Oncology, and Stem Cell Transplantation

Faculty

Andrew L. Kung, MD, PhD

Academic Title(s):

Professor of Pediatrics
Robert and Ellen Kapito Professor of Pediatrics at CUMC
Chief, Division of Hematology, Oncology and Stem Cell Transplant

Contact Information:

Tel: (212) 342-4624
Fax: (212) 305-8428
Email: akung@columbia.edu

Education

  • Florida State University, B.S., 1987
  • Stanford University School of Medicine, Ph.D., 1993
  • Stanford University School of Medicine, M.D., 1994

Postgraduate Training

  • Internship and Residency, Boston Children’s Hospital, 1994-1996
  • Fellowship, Boston Children’s Hospital and Dana-Farber Cancer Institute, 1996-1999

Interests/Specialties

  • Stem Cell Transplantation
  • Translational Oncology Research
  • Drug Discovery
  • Epigenetics
  • Molecular Imaging

Click here to review Dr. Kung's publications.

Stem Cell Transplantation Faculty

Christopher Adrian, MD

Academic Title(s)

Assistant Professor of Pediatrics at CUMC

Contact Information

Fax: (212) 305-8428
Email: ca2597@columbia.edu

Education

  • University of Florida, B.A., 1993
  • University of Iowa, M.F.A., 1995
  • Eastern Virginia Medical School, M.D., 2002
  • Harvard Divinity School, M.Div., 2011

Postgraduate Training

  • Internship, Pediatrics, University of California San Francisco, 2001
  • Residency, Pediatrics, University of California San Francisco, 2005
  • Fellowship in Medical Ethics, Harvard Medical School, 2010
  • Fellowship, Pediatric Hematology/Oncology, University of California San Francisco, 2011

Awards and Honors

  • John Simon Guggenheim Memorial Foundation Fellow, 2009
  • American Academy of Arts and Letters Rosenthal Foundation Award, 2009
  • National Foundation for the Arts Fellowship, 2001

Interests/Specialties

  • Psychological care of pediatric cancer patients and their families
  • Narrative medicine
  • Hospital chaplaincy

Click here to review Dr. Adrian's publications.

Monica Bhatia, MD

Academic Title(s)

Assistant Professor of Pediatrics at CUMC

Contact Information

Tel: (212) 305-9138
Fax: (212) 305-8408
Email: mb2476@columbia.edu

Education

  • Boston University, B.A., 1992
  • St. George's University School Medicine, M.D., 1997

Postgraduate Training

  • Residency, Albany Medical College, 1997-2001
  • Fellowship, Children's National Medical Center, Washington, DC, 2001-2004

Interests/Specialties

  • Hemoglobinopathies
  • Immunodeficiencies
  • Acute Myeloid Leukemia (AML)

Learn more about Dr. Bhatia

Dr. Bhatia's research interests include reduced intensity allogeneic stem cell transplantation for the treatment of acute and chronic childhood leukemias with special interest in Acute Myeloid Leukemia (AML); as well as the safety and efficacy of stem cell transplantation for the treatment of Hemoglobinopathies and Immunodeficiencies. She is the Clinical Director of the Pediatric Blood & Marrow Transplantation (BMT) program, and the Medical Director of the Quality Management Program for the Division of Pediatric BMT. Dr. Bhatia is also the founder and director of the Monthly Pediatric Immunodeficiency Outpatient Clinic which provides Muli-Disciplinary care in one clinical setting to children with Immunodeficiencies. Specialists that participate include but are not limited to genetics, infectious diseases, dermatology, and neurology.

Click here to review Dr. Bhatia's publications.

Diane George, MD

Academic Title(s)

Assistant Professor of Pediatrics at CUMC

Contact Information

Tel: (212) 305-2466
Fax: (212) 305-8428
Email: dg2039@columbia.edu

Education

  • Grinnell College, IA, 1973-1977
  • M.Div., Union Theological Seminary, New York, NY, 1977-1980
  • Premedical Education, Columbia University, New York, NY, 1981-1984
  • Cornell University Medical College, New York, NY, M.D., 1984-1988

Postgraduate Training

  • Intern, Pediatrics Johns Hopkins Hospital Baltimore, MD, 1988-1989
  • Residency, Johns Hopkins Hospital, Balitimore, MD, 1989-1991
  • Fellowship, Pediatrics Hematology/Oncology, MSKCC, New York, NY, 1991-1993
  • Chief Fellow, Pediatrics MSKCC, New York, NYU, 1993-1994

Interests/Specialties

  • Unrelated donor transplants
  • Infectious complications of stem cell transplantation
  • Supportive care of stem cell transplantation patients

Learn more about Dr. George

Dr. George joined the Division of Pediatric BMT in 2001 and since that time has had a leading role in enhancing the BMT Outpatient Center by serving as the BMT Outpatient Director. She brings expertise/experience in the areas of unrelated donor transplantation and infectious complications of allo BMT. Dr. George is the BMT Division representative physician for the National Marrow Donor Program and oversees the NMDP sponsored clinical research protocols.

Click here to review Dr. George's publications.

John Horan, MD, MPH

Academic Title(s)

Assistant Professor of Pediatrics at CUMC

Contact Information

Tel: (212) 305-2598
Fax: (212) 305-8428
Email: jth2148@columbia.edu

Education

  • Colgate University, B.A., 1984
  • New Jersey Medical School, M.D. 1993
  • University of Rochester, M.P.H. 2003

Postgraduate Training

  • Residency, University of Rochester Medical Center, 1993-1996
  • Fellowship, Stem Cell Transplant, University of Rochester Medical Center, 1996-1997
  • Fellowship, Pediatric Hematology/Oncology, Children’s National Medical Center, 1997-1998
  • Fellowship, Pediatric Hematology/Oncology, University of Rochester Medical Center, 1998-2000

Interests/Specialties

  • Blood and Marrow Transplant for Non-Malignant Diseases
  • Acute Myeloid Leukemia
  • Adolescent and Young Adult Oncology

Click here to review Dr. Horan's publications.

Prakash Satwani, MD

Academic Title(s)

Associate Professor of Pediatrics at CUMC

Contact Information

Tel: (212) 305-1183
Fax: (212) 305-8428
Email: ps2087@columbia.edu

Education

  • Ghandi Medical College, Bhopal, India, MBBS, 1996

Postgraduate Training

  • Residency, King Edward Memorial Hospital, Mumbai, India, 1996-1999
  • Residency, The Brooklyn Hospital Center, Brooklyn, New York, 1999-2001
  • Residency, Medical University of South Carolina, Charleston, South Carolina, 2001-2002
  • Fellowship, Columbia University, New York, New York
  • Fellowship, Columbia University, 2002-2004
  • Research Fellowship, Columbia University, 2004-2005

Interests/Specialties

  • Stem cell Transplantation for leukemias and lymphomas
  • Adoptive cellular Immunotherapy for malignant diseases
  • Reduced Intensity stem cell transplantation

Learn more about Dr. Satwani

Dr. Satwani is active in both clinical and translational research. He is currently the Principal Investigator of an open study funded by Osiris Therapeutics: A Phase III, Randomized, Double Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Prochymal™ (Ex-vivo Cultured Adult Human Mesenchymal Stem Cells) Infusion for the Treatment of Patients Who Have Failed to Respond to Steroid Treatment for Acute GVHD.

Dr. Satwani is also Co- Investigator of studies funded by the Pediatric Cancer Research Foundation (PCRF) for work in the PCRF Laboratory at Morgan Stanley Children's Hospital of NY Presbyterian. The focus is on continued research into the molecular and/or proteomic basis of selected pediatric solid tumors and hematological malignancies, to perform basic and translational research in developmental and tumor immunology, conduct laboratory research in transplantation and stem cell biology and to execute translational and clinical research in selected pediatric cancers and lethal blood/immune disorders.

Click here to review Dr. Satwani's publications.

Hematology Faculty

Gary Brittenham, MD

Academic Title(s):

James A. Wolff Professor of Pediatrics and Professor of Medicine

Contact Information:

Tel: (212) 305-7005
Fax: (212) 305-0053
Email: gmb31@columbia.edu

Education

  • Johns Hopkins University, Baltimore, MD
  • École Pratique des Hautes Études, Paris, France
  • Case Western Reserve University School of Medicine, Cleveland, OH, M.D.

Postgraduate Training

  • NIH Hematology Trainee and Teaching Fellow, Metropolitan General Hospital
  • Case Western University School of Medicine

Interests/Specialties

  • Iron deficiency and transfusional iron overload
  • Iron metabolism
  • Cerebral malaria and malarial anemia
  • Magnetic resonance imaging and measurement of heart and liver iron
  • Basic and clinical research in disorders of the red blood cell and of iron metabolism, concentrating on (i) sickle cell disease, thalassemia and other hemoglobinopathies, (ii) iron deficiency and overload, and (iii) the pathogenesis of malarial anemia.

Click here to review Dr. Brittenham's publications.

Staci Arnold, MD

Academic Title(s):

Instructor in Pediatrics at CUMC

Contact Information:

Tel: (212) 305-8316
Email: sa2812@columbia.edu

Education

  • Spelman College, BS, 2001
  • Duke University School of Medicine, MD, 2006
  • Duke University Fuqua School of Business, MBA, 2006

Postgraduate Training

  • Intern and Resident, Pediatrics, Duke University, 2006-2009
  • Fellow, Pediatric Hematology/Oncology, Columbia University Medical Center, 2010-2013

Interests/Specialties

  • Non-malignant stem cell transplant
  • Cost effectiveness and cost-benefit analysis
  • Health outcomes and policy

Learn more about Dr. Arnold

Dr. Arnold has embarked upon an academic career focused on advocacy and healthcare-related public policy. She is working to develop evidence-based research supporting cost-effective interventions. Her clinical practice and research provide objective data to drive policy guidelines and to decrease health disparities.

Click here to review Dr. Arnold's publications.

Katherine Ender, MD, MS

Academic Title(s):

Assistant Professor of Pediatrics at CUMC

Contact Information:

Tel: (212) 305-2466
Fax: (212) 305-0053
Email: ke2144@columbia.edu

Education

  • Harvard University, Cambridge, MA, A.B., 1995
  • Rush University Medical College, Chicago, IL, M.D., 2000
  • Northwestern University, Masters of Science in Clinical Investigation, 2004-2006

Postgraduate Training

  • Pediatric Internship, Johns Hopkins Hospital, Baltimore, MD, 2000-2001
  • Pediatric Residency, Medical College of Wisconsin, Milwaukee, WI, 2001-2003
  • Pediatric Hematology/Oncology Fellowship, Children's Memorial Hospital, Northwestern University, Chicago, IL, 2003-2006

Interests/Specialties

  • Sickle Cell Disease
  • Disorders of bleeding and clotting
  • Anemia and red blood cell disorders
  • Platelet disorders
  • Medical management of sickle cell disease, especially hydroxyurea and new therapeutic agents, vaso-occlusive pain management, and sickle cell comprehensive care

Nancy S. Green, MD

Academic Title(s):

Professor of Pediatrics at CUMC
Associate Dean for Clinical Research Operations
Associate Director, Irving Institute for Clinical and Translational Research

Contact Information:

Tel: (212) 305-0494
Fax: (212) 305-0053
Email: nsg11@columbia.edu

Education

  • Tufts University
  • Columbia University College of Physicians and Surgeons

Postgraduate Training

  • Intern and Resident in Pediatrics, Columbia U. – Presbyterian Hospital, NYC
  • Fellowship in Pediatric Hematology-Oncology, Columbia U. – Presbyterian Hospital, NYC
  • Post-doctoral fellowship in Cell Biology, Albert Einstein College of Medicine, NYC

Interests/Specialties

  • Sickle cell disease
  • Newborn screening
  • Benign hematology

Click here to review Dr. Green's publications.

David Hart, MD

Academic Title(s):

Assistant Professor of Pediatrics at CUMC

Education

  • Louisiana State University, Chemistry, B.A., 1969
  • Baylor College of Medicine, M.D., 1973

Post-Doctoral Training:

  • Intern and resident, Pediatrics, New York University School of Medicine, 1973-1975
  • Fellow in Pediatric Hematology Oncology, New York University School of Medicine, 1975-1977

Interests/Specialties

  • Clinical Management of Patients with Thalassemia
  • Clinical Management of Patients with Sickling Disorders
  • Lead Poisoning, Pathophysiology
  • Clinical Management of Hemostatic Disorders and Thrombophilia

Learn more about Dr. Hart

Dr. Hart is an Associate Clinical Professor of Pediatrics with extensive experience in the care of patients with sickle-cell disease, thalassemia and disorders of hemostasis. He has a special interest in the diagnosis and treatment of lead poisoning.

Click here to review Dr. Hart's publications.

Margaret T. Lee, MD

Academic Title(s):

Associate Professor of Pediatrics at CUMC

Contact Information:

Tel: (212) 305-2466
Fax: (212) 305-0053
Email: ML653@columbia.edu

Education

  • University of Santo Tomas,(Manila, Philippines), B.S. Medical Technology, 1981
  • University of Santo Tomas,(Manila, Philippines), Doctor of Medicine, 1985

Post-Doctoral Training

  • Santo Tomas University Hospital (Manila, Philippines), Internship and Residency in Pediatrics, 1990
  • New York University Med Center/Bellevue Hospital Med Center, Fellowship in Pediatric Hematology/Oncology, 1994

Interests/Specialties

  • Sickle cell disease
  • Bleeding disorders
  • Clotting disorders
  • Benign hematology
  • Stroke in sickle cell disease
  • Pulmonary hypertension in children with sickle cell disease

Click here to review Dr. Lee's publications. 

Oncology Faculty

Michael Weiner, MD

Academic Title(s):

Hettinger Professor of Pediatrics at CUMC

Contact Information:

Tel: (212) 305-7112
Fax: (212) 305-3020
Email: mw216@columbia.edu

Education

  • Dickinson College, B.A., 1968
  • State University of New York, Upstate Health Sciences Center, Syracuse, 1972

Postgraduate Training

  • Internship, Montefiore Hospital, 1973
  • Residency, Thomas Jefferson University Hospital, 1974
  • Fellowship, New York University Medical Center, 1976
  • Fellowship, Johns Hopkins Hospital, 1977

Interests/Specialties

  • Pediatric Leukemia
  • Pediatric Lymphomas

Learn more about Dr. Weiner

Dr. Weiner has been involved at a national level in the treatment of children and adolescents with Hodgkin's disease. His leadership of a Pediatric Oncology Group protocol more than 20 years ago demonstrated that early response to therapy was key to long-term survival; this approach is now the paradigm upon which all present and future studies are based. In addition, his visionary leadership has been instrumental in establishing programs for alternate medicine, and for the care of adolescents and young adults.

Click here to review Dr. Weiner's publications.

Carrie Brownstein, MD

Academic Title(s):

Assistant Professor of Pediatrics at CUMC

Contact Information:

Tel: (212) 305-9770, press 1, then 1
Fax: (212) 305-5848
Email: cb254@columbia.edu

Education

  • University of Michigan, A.B., Psychology, 1992
  • Tufts University School of Medicine, M.D., 1996

Postgraduate Training

  • Internship, New York-Presbyterian Hospital/ Columbia University Medical Center, 1997
  • Residency, New York-Presbyterian Hospital Columbia University Medical Center, 1999
  • Fellowship, Memorial Sloan-Kettering Cancer Center, 2002

Interests/Specialties

  • Pediatric oncology
  • Leukemia
  • Lymphoma

Click here to review Dr. Brownstein's publications.

Filemon Dela Cruz, MD

Academic Title(s):

Assistant Professor of Pediatrics at CUMC

Contact Information:

Tel: (212) 305-5808, Press 1 then 1
Fax: (212) 305-5848
Email: fd2177@columbia.edu

Education

  • Reed College, Portland, OR, B.A., 1998
  • University of California at Davis, Davis, CA, M.D., 2004

Postgraduate Training

  • Internship, University of California at San Francisco, San Francisco, CA, 2005
  • Residency, University of California at San Francisco, San Francisco, CA, 2007
  • Fellowship, Columbia University Medical Center, Morgan Stanley Children’s Hospital, New York, NY, 2010

Interests/Specialties

  • Pediatric Solid Tumors

Click here to review Dr. Dela Cruz' publications.

Adolfo Ferrando, MD, PhD

Academic Title(s):

Associate Professor of Pediatrics and Pathology
Director WOLF Foundation Leukemia/Lymphoma Laboratory

Contact Information:

Tel: (212) 851-4611
Fax: (212) 851-5256
Email: af2196@columbia.edu

Education

  • University of Oviedo, Spain
  • University of Oviedo, Spain, M.D. 1994
  • University of Oviedo, Spain, Ph.D. 1999

Postgraduate Training

  • Residency, Hospital Central de Asturias, 1998
  • Fellowship, Dana Farber Cancer Institute, 2003

Interests/Specialties

  • Pediatric Leukemia and Lymphoma

Learn more about Dr. Ferrando

The research program in Dr. Ferrando's leukemia research laboratory focuses on the identification of new molecular therapies for acute leukemias. Using highly innovative tools and genomic approaches the Ferrando lab has identified mutations in key genes responsible for the malignant transformation of leukemic cells. Some of their latest work shows that blocking the activity of these mutations with targeted drugs impairs leukemic cell growth and can reverse chemotherapy resistance.

Click here to review Dr. Ferrando's publications.

James H. Garvin, Jr., MD, PhD

Academic Title(s):

Professor of Pediatrics at CUMC
Director, the Alfano Family Foundation Program in Pediatric Neuro-Oncology

Contact Information:

Tel: (212) 305-9770 Press 1, then 1
Fax: (212) 305-5848
Email: jhg1@columbia.edu

Education

  • Harvard University, A.B. Chemistry, 1968
  • Thomas Jefferson University Medical College, M.D., 1976
  • MIT, PhD, Biophysical Chemistry, 1974

Postgraduate Training

  • Internship, Children's Hospital of Philadelphia, 1977
  • Residency, Children's Hospital of Philadelphia, 1978
  • Fellowship, Dana Farber Cancer Institute, 1982

Interests/Specialties

  • Pediatric Brain Tumors
  • Neuro-Oncology
  • Bone Marrow Transplant
  • Late Effects

Learn more about Dr. Garvin

Dr. Garvin is a national leader in the field of brain tumor clinical investigation. He has been the principal investigator of a Children's Cancer Group study for the treatment of ependymoma and is an active participant in the Pediatric Brain Tumor Consortium. As section leader he coordinates the efforts of the Morgan Stanley Children's Hospital of New York's multi-disciplinary team of neurosurgeons, radiation oncologists, and child neurologists.

Click here to review Dr. Garvin's publications.

Julia Glade Bender, MD

Academic Title(s):

Associate Professor of Pediatrics at CUMC
Director Pediatric Cancer Foundation Developmental Therapeutics Program

Contact Information:

Tel: (212) 305-9770 Press 1, then 1
Fax: (212) 305-5848
Email: jg589@columbia.edu

Education

  • Yale University, B.S., Biology, 1988
  • University of Pennsylvania School of Medicine, M.D., 1992

Postgraduate Training

  • Internship, Mount Sinai School of Medicine, CUNY, 1995
  • Residency, Mount Sinai School of Medicine, CUNY
  • Fellowship, Memorial Sloan-Kettering Cancer Center, 1998

Interests/Specialties

  • Neuroblastoma,
  • Wilm's Tumor, Phase I Clinical Trials

Learn more about Dr. Bender

Dr. Bender is the Director of the Pediatric Cancer Foundation Developmental Therapeutics Program, which is one of only 21 Phase I research programs supported by the National Cancer Institute (NCI) and the Children's Oncology Group (COG). They are also members of the New Approaches to Neuroblastoma Therapy (NANT) and Therapeutic Advances in Childhood Leukemia (TACL) consortia for which she serves as local Principal Investigator. Additionally, she is the clinical translational member of the Pediatric Tumor Biology laboratory which focuses on the biologic effects of vascular endothelial growth factor (VEGF) blockade and other targeted therapies on experimental models of pediatric solid tumors. She led the first pediatric trial of bevacizumab, an anti-VEGF monoclonal antibody, in children with relapsed solid tumors and is recognized as a clinical leader in the field of pediatric antiangiogenesis. She is also interested in studying patient decision making and quality of life on Phase I trials. She sits on the COG Steering Committees for Developmental Therapeutics and Bioethics, and the COG Bone Sarcoma and Neuroblastoma Disease Committees. Her clinical practice is limited to Solid tumors (e.g. neuroblastoma, sarcoma and germ cell tumors) and phase I consultations.

Click here to review Dr. Bender's publications.

Kara Kelly, MD

Academic Title(s):

Professor of Pediatrics at CUMC
Director Integrative Therapies Program for Children with Cancer
Director Leukemia/Lymphoma Program

Contact Information:

Tel: (212) 305-9770 Press 1, then 1
Fax: (212) 305-5848
Email: kk291@columbia.edu

Education

  • Brown University, B.A. Human Biology, 1985
  • State University of New York, Buffalo, M.D., 1989

Postgraduate Training

  • Internship, Children's Hospital of Philadelphia, 1990
  • Residency, Children's Hospital of Philadelphia, 1992
  • Fellowship, Children's Hospital of Philadelphia, 1996

Interests/Specialties

  • Pediatric Leukemia and Lymphoma
  • Histiocytic disorders
  • Complementary therapies
  • Late effects of cancer treatment

Learn more about Dr. Kelly

Dr. Kelly is the director of the Pediatric Leukemia/Lymphoma program, where she also serves as the local principal investigator for several Phase III and other correlative trials for the management of acute lymphoblastic leukemia through the Dana Farber Cancer Institute Acute Lymphoblastic Leukemia Consortium. She is leading an investigation of how dietary intake of micronutrients such as folate and antioxidants impact toxicity to chemotherapy. In the Children's Oncology Group (COG), she is a member of the Hodgkin lymphoma steering committee. She chaired a national trial of the chemotherapy regimen, BEACOPP, in children and adolescents with high risk Hodgkin lymphoma that resulted in the best outcome of any trial in this subgroup of patients. She is currently chairing the successor trial for high risk Hodgkin lymphoma that will build upon these results. She is also leading an effort to incorporate measures of quality of life into treatment trials across risk groups in COG Hodgkin lymphoma trials.

She is also the Medical Director of the Integrative Therapies Program for Children with Cancer, a program which provides free integrative clinical services and educational resources and to children with cancer and their families through and beyond cancer treatment. She is the principal investigator of numerous research trials investigating the use of complementary supportive therapies among children with cancer, including studies on acupuncture and herbs such as milk thistle. She has led several studies examining the effects of antioxidant supplements during chemotherapy for cancer. She is a member of the COG Cancer Control steering committee and she serves as chair of the Integrative Therapies Committee, where she is leading efforts to evaluate different integrative therapies such as fish oils for neurocognitive dysfunction and acupressure for nausea treatment in the management of children with brain tumors. She is a member of the National Cancer Institute's PDQ Complementary and Alternative Medicine Editorial Board. She is also a member of the Board of Directors of the Society of Integrative Oncology (SIO) and she is the Scientific Chair of the 2009 Annual meeting.

Click here to review Dr. Kelly's publications.

Dennis Kuo, MD

Academic Title(s):

Assistant Professor of Pediatrics at CUMC

Contact Information:

Tel: (212) 305-9770 Press 1, then 1
Fax: (212) 305-5848
Email: djk2123@columbia.edu

Education

  • Harvard University, B.A., Biochemistry, 1995
  • University of California, San Francisco, M.D., 2000
  • University of California, Berkeley, M.S., 1998

Postgraduate Training

  • Internship, New York University Medical Center, 2001
  • Residency, New York University Medical Center, 2003
  • Fellowship, Stanford University, 2006

Interests/Specialties

  • Pediatric Leukemia

Learn more about Dr. Kuo

Dennis John Kuo M.D. has a part of our team since 2006. His clinical interests are in the treatment, supportive care and long-term survivorship issues surrounding the care of patients with leukemias and lymphomas. He speaks Mandarin Chinese and Spanish, and sees patients at both the Herbert Irving Child & Adolescent Oncology Center at Columbia University Medical Center and our affiliate, St. Joseph's Children's Hospital in Paterson, New Jersey.

Click here to review Dr. Kuo's publications.

Anna Lasorella, MD

Academic Title(s):

Associate Professor of Pediatrics

Contact Information:

Tel: (212) 851-5240
Fax: (212) 851-5267
Email: al2179@columbia.edu

Education

  • Liceo Ginnasio Domenica Morea Conversano, Bari, Italy, 1976
  • Catholic University School of Medicine, Rome, M.D., 1982

Postgraduate Training

  • Internship, Catholic University School of Medicine, 1984
  • Residency, Catholic University School of Medicine
  • Fellowship, Gustave Roussy Institute, Villejuif (Paris), France

Interests/Specialties

  • Pediatric oncology research in molecular neuro-oncology
  • Brain tumors

Learn more about Dr. Lasorella

Unrestrained proliferation and differentiation block are hallmarks of childhood cancers of the nervous system. Our laboratory is using an interdisciplinary approach that includes cellular biology, mouse genetics and biochemical methods to integrate basic research with an understanding of malignant transformation caused by two transcription factors that are critically involved in normal development of the nervous system, namely Id2 and N-Myc.

- The Id2 protein is a general inhibitor of differentiation and positive regulator of proliferation that is frequently recruited by oncogenic signals to mediate multiple hallmarks of neoplasia. Our work aims at identifying the molecular pathways engaged by Id2 to prevent differentiation, promote cell proliferation and induced invasion and neoangiogenesis in cancer of the nervous system.

- To address the function of deregulated N-Myc in neuroblastoma we identified the natural protein complexes engaged by N-Myc using a state-of-the-art proteomic approach in human neuroblastoma cells. Among the N-Myc protein partners we identified the ubiquitin ligase Huwe1. Huwe1 targets N-Myc protein for degradation during differentiation and cell cycle arrest in the developing nervous system and neuroblastoma cells. The major implication of this work is that continuous self-renewal and inhibition of differentiation of neural stem cells requires protection of the N-Myc oncoprotein from the destructive activity of the Huwe1. The most exciting novel finding that originated from the identification of the Huwe1-N-Myc pathway in neural cells is that primary neural tumors in humans carry focal genetic deletions of the Huwe1 gene. These results identify Huwe1 as a new tumor suppressor gene in neural tumors and establish an unprecedented link between neural stem cell renewal and tumor development.

Alice Lee, MD

Academic Title(s):

Assistant Professor of Pediatrics at CUMC
Co-Director, Fellowship Program

Contact Information:

Tel: (212) 305-9770 Press 1, then 1
Fax: (212) 305-5848
Email: al2041@columbia.edu

Education

  • Boston University, B.A., Medical Sciences, 1994
  • Boston University School of Medicine, M.D., 1998

Postgraduate Training

  • Internship, Southern Illinois University School of Medicine, 1999
  • Residency, Southern Illinois University School of Medicine, 2001
  • Fellowship, Morgan Stanley Children's Hospital/Columbia University Medical Center, 2004

Interests/Specialties

  • Neuroblastoma
  • Wilm's Tumor
  • Solid Tumors

Click here to review Dr. Lee's publications.

Jennifer Levine, MD, MSW, MS

Academic Title(s):

Assistant Professor of Pediatrics at CUMC
Director Center for Survivor Wellness

Contact Information:

Tel: (212) 305-9770 Press 1, then 1
Fax: (212) 305-5848
Email: Jl175@columbia.edu

Education

  • Amherst College, B. A., Psychology, 1988
  • Hunter College School of Social Work, MSW, 1991
  • Columbia University School of Public Health, MS Biostatistics, 2008
  • University of Virginia School of Medicine, M.D., 1999

Postgraduate Training

  • Internship, Yale-New Haven Hospital, 2000
  • Residency, Yale-New Haven Hospital, 2003
  • Fellowship, Morgan Stanley Children's Hospital/Columbia University Medical Center, 2006

Interests/Specialties

  • Pediatric Leukemia
  • Late Effects of Cancer Therapy

Learn more about Dr. Levine

Dr. Levine's clinical interests are in the treatment of pediatric leukemia and lymphoma. As the medical director of the Center for Survivor Wellness, she is interested in understanding and evaluating the medical and psychosocial long term complications of treatment for pediatric cancer. The research interests of the Center include fertility preservation, maximizing optimal nutrition and exercise in survivors, and understanding barriers to long term care.

Click here to review Dr. Levine's publications.

Judith Marcus, MD

Academic Title(s):

Professor of Pediatrics at CUMC

Contact Information:

Tel: (212) 305-9770 Press 1, then 1
Fax: (212) 305-5848
Email: jrm11@columbia.edu

Education

  • Barnard College, Columbia University, B.A., 1964
  • New York University School of Medicine, M.D., 1971

Postgraduate Training

  • Internship, Albert Einstein College of Medicine, 1972
  • Residency, Albert Einstein College of Medicine, 1974
  • Fellowship, Memorial Sloan-Kettering Cancer Center, 1979

Interests/Specialties

  • Pediatric Leukemia

Manuela Orjuela, MD, ScM

Academic Title(s):

Assistant Professor of Pediatrics at CUMC

Contact Information:

Tel: (212) 305-9770 Press 1, then 1
Fax: (212) 305-5848
Email: mao5@columbia.edu

Education

  • Yale College, B.A., Spanish, 1985
  • Yale University School of Medicine, M.D., 1989
  • Harvard School of Public Health, ScM, Epidemiology, 1996

Postgraduate Training

  • Internship, Children's Hospital of New York Presbyterian, 1990
  • Residency, Children's Hospital of New York Presbyterian, 1992
  • Fellowship, Memorial Sloan-Kettering Cancer Center, 1995
  • Fellowship, Harvard School of Public Health, Cancer Epidemiology, 1997

Interests/Specialties

  • Pediatric Brain Tumors
  • Retinoblastoma
  • Post Transplant Lymphoproliferative Disorder

Click here to review Dr. Orjuela's publications.

Stephen Sands, PsyD

Academic Title(s):

Associate Professor of Pediatrics and Psychiatry at CUMC
Director Valerie Fund Psychosocial Program in Pediatric Oncology

Contact Information:

Tel: (212) 305-9770 Press 1, then 1
Fax: (212) 305-5848
Email: ss2341@columbia.edu

Education

  • University of Michigan, B.A., Psychology, 1984
  • New York University, PsyD, Child and School Psychology 1996
  • New York University, M.A., Child and School Psychology, 1994

Postgraduate Training

  • Internship, St. Lukes-Roosevelt Hospital Center, 1997
  • Fellowship, Memorial Sloan-Kettering Cancer Center, 1998

Interests/Specialties

  • Child Psychology
  • Pediatric Neuropsychology
  • Late Effects

Learn more about Dr. Sands

Dr. Stephen Sands is actively involved in investigating the neuropsychological and quality of life late effects arising from the treatment of pediatric oncology. Specific international and national protocols that Dr. Sands has assumed a leadership role in involve the examination of the long-term impacts from the use of cranial irradiation and chemotherapy for the treatment of various brain tumors and acute lymphoblastic leukemia upon the developing brain, as well as the social-emotional and behavioral sequelae.

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Maria-Luisa Sulis, MD

Academic Title(s):

Assistant Professor of Pediatrics at CUMC

Contact Information:

Tel: (212) 305-9770 Press 1, then 1
Fax: (212) 305-5848
Email: mls95@columbia.edu

Education

  • Liceo Classico Dettori, Cagliari, Italy, 1987
  • University Of Cagliari, Italy, M.D., 1993

Postgraduate Training

  • Internship, St. Vincent's Hospital, 1997
  • Residency, St. Vincent's Hospital, 1999
  • Fellowship, New York-Presbyterian Hospital/Columbia University Medical Center, 2002

Interests/Specialties

  • Pediatric Leukemia

Learn more about Dr. Sulis

The main focus of Dr. Sulis's research in the laboratory is the study of the role of NOTCH1 in the development of T cell ALL. Until now almost 2/3 of the cases of T-ALL have been found to have aberrant expression of the NOTCH1 pathway by either activating mutations of the NOTCH1 receptor or inactivating mutations of FBW7 which normally degrades NOTCH1. They believe that activated NOTCH1 pathway may be a universal event in T-ALL, therefore she is interested in finding alternative, yet unknown ways, to activate it. Currently she is studying the expression profile of mouse T-cell lymphoblastic lymphomas originated from different transgenic models. She has found that a subset of them carry activated Notch1 in the absence of any of the mutations mentioned above suggesting the existence of alternative mechanisms of Notch1 activation. By comparing the expression profile of the Notch 1 wild type tumors with the Notch1 mutated ones and the ones which are neither wild type nor mutated but have an aberrantly activated pathway, they hope to identify genes or pathways that can interfere with and activate Notch1 and ultimately lead to the development of T-cell lymphomas. The candidate genes or pathways will then be validated with a series of experiments in the second part of the project.

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Darrell Yamashiro, MD, PhD

Academic Title(s):

Associate Professor of Pediatrics and Surgery at CUMC
Director Taybanz/ Matthews Family Foundation Solid Tumor Laboratory

Contact Information:

Tel: (212) 305-9770 Press 1, then 1
Fax: (212) 305-5848
Email: dy39@columbia.edu

Education

  • University of California, San Diego, B.S. Bioengineering, 1982
  • University of California, San Diego, B.A. Biology, 1982
  • New York University School of Medicine, M.D.,1989
  • New York University, M.S., Pharmacology, 1984
  • New York University, Ph.D., Pharmacology, 1987

Postgraduate Training

  • Internship, Children's Hospital of Philadelphia, 1990
  • Residency, Children's Hospital of Philadelphia, 1992
  • Fellowship, Children's Hospital of Philadelphia, 1995

Interests/Specialties

  • Neuroblastoma
  • Wilm's Tumor
  • Hepatoblastoma
  • Tumor angiogenesis
  • Biology of solid tumors

Learn more about Dr. Yamashiro

The laboratory of Dr. Darrell Yamashiro, Pediatric Oncology, examines the role of angiogenesis in the growth and metastasis of pediatric solid tumors. They have demonstrated that blocking the angiogenic factor vascular endothelial growth factor (VEGF) inhibited growth of xenografts tumors such as neuroblastoma, Wilms, and hepatoblastoma. These preclinical studies led to the Children's Oncology Group/NCI Phase I study of the anti-VEGF antibody bevacizumab (Avastin) in children, chaired by Dr. Julia Glade Bender, Pediatric Oncology, and Dr. Yamashiro (J. Clin. Oncology, 26: 399-405, 2008). His laboratory is currently examining the role of alternative angiogenic pathways and the mechanisms by which tumors evade anti-angiogenic therapy. These include the Notch and placental growth factor/VEGFR1 pathways.

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Shan Zha, MD, PhD

Academic Title(s):

Assistant Professor of Pediatrics Pathology & Cell Biology (in the Institute for Cancer Genetics)

Contact Information:

Tel: (212) 851-4779
Email: sz2296@columbia.edu

Education

  • Peking University, MD, 1998
  • Johns Hopkins University, PhD, 2003

Interests/Specialties

  • Mechanisms of Genomic Instability in Normal and Malignant Lymphoid Cells

Click here to review Dr. Zha's publications.