Gastroenterology, Hepatology and Nutrition

Trainees

Dana Goldner, MD (2012-2015)

Education

  • Massachusetts Institute of Technology, B.S., 2004
  • Weill Cornell Medical College, M.D., 2009

Postgraduate Training

  • Resident, Pediatrics, Massachusetts General Hospital, 2009 - 2012
  • Fellow, Pediatric Gastroenterology, Hepatology, and Nutrition, Columbia University Medical Center, 2012-present

Awards and Honors

  • 2013-2015 Pediatric Science Development Award
  • Weill Cornell Research Grant: received funding for the Breast Cancer research
  • Pediatric Resident Teaching Award, MGH,  2010
  • 2010 Teaching and Tomorrow Program travel grant from North American Society for Pediatrics 
  • 2004: Thomas J. Bardos Science Education award of the American Association for Cancer Research

Research Plan

  • Dana Goldner is working under the guidance of Dr. Gerard Karsenty, Chair of the Department of Genetics and Development, investigating the role of peripherally produced serotonin in glucose and lipid metabolism. She plans to study the underlying molecular mechanisms involved in serotonin’s regulation of energy metabolism which has implications for the development of new therapies for the treatment of hyperlipidemia and insulin resistance.

Sivan Kinberg, MD (2012-2015)

Education

  • Columbia University, B.A., 2004
  • Touro College, School of Health Sciences, M.S., 2005
  • Technion Israel Institute of Technology, M.D., 2009

Postgraduate Training

  • Intern and Resident, Pediatrics, Cohen Children's Medical Center, North Shore-Long Island Jewish Hospital, 2009-2012
  • Fellow, Pediatric Gastroenterology, Hepatology, and Nutrition, Columbia Presbyterian Medical Center, 2012-present

Awards and Honors

  • F. Slater Jackson Prize, awarded for highest standing in Molecules, Cells and Tissues unit.
  • Best Thesis Award, awarded for thesis entitled, "The Mechanism of Cystic Fibrosis: A Review of the Literature"

     

Research Plan

  • Sivan Kinberg has been awarded a National Library of Medicine post-doctoral training grant. She will be pursuing a Master of Art’s degree in Biomedical Informatics at the Graduate School of Arts and Sciences at Columbia University Medical Center. The program includes a combination of coursework and a research project, with mentorship from experts in the field. The research areas include clinical informatics (e.g., related to electronic health records or health practice research), public health informatics, clinical research informatics, and translational bioinformatics (including precision medicine).

Joseph Andrew Picoraro, MD (2013)

Education

  • Duke University, Trinity College of Arts and Sciences, BS, 2005
  • University of Pennsylvania, Perelman School of Medicine, MD, 2010

Postgraduate Training

  • Intern and Resident, Department of Pediatrics, Children’s Hospital of Philadelphia , 2010-2013
  • Pediatric Gastroenterology, Hepatology and Nutrition Fellow, Columbia University Medical Center, 2013

Anne Abbott Pierog (2011-2014)

Education

  • Dartmouth College, B.A., 2004
  • Tufts School of Medicine, MD, 2008

Postgraduate Training

  • Intern and Resident, Columbia University, 2008 - 2011
  • Fellow, Pediatric Gastroenterology, Hepatology, and Nutrition, Columbia University Medical Center, 2011-present

Interests/Specialties

  • Congenital Diaphragmatic Hernia
  • Endoscopy

Research Plan

  • Mentor: Ali Mencin, MD
  • Survivors of congenital diaphragmatic hernia (CDH) suffer from short and long-term gastrointestinal sequelae including reflux, failure to thrive and motility disorders. Our hospital is a referral center for babies pre- and post-natally diagnosed with CDH due to our NICU, ECMO program and surgical expertise. I will be looking at risk factors that predispose CDH survivors to worsening foregut dysfunction in order to achieve a better algorithm and standard of care to better optimize gastrointestinal and nutritional management in this population.

Svetlana L. Sabel, MD (2013)

Education

  • University of Virginia, B.S, 2006
  • University of Virginia School of Medicine, MD, 2010

Postgraduate Training

  • Intern and Resident, Department of Pediatrics, New York University 2010-2013
  • Fellow, Pediatric Gastroenterology, Columbia Presbyterian Medical Center, 2013

Sarah Anne Taylor, MD (2011-2014)

Education

  • Hamilton College, B.A., 2003 Summa Cum Laude
  • New York University School of Medicine, MD, 2008

Postgraduate Training

  • Intern and Resident, Albert Einstein College of Medicine, The Children's Hospital at Montefiore, 2008 - 2012
  • Fellow, Pediatric Gastroenterology, Hepatology, and Nutrition, Columbia University Medical Center, 2011-present

Awards and Honors

  • 2012-2014 Pediatric Science Development Award
  • 2003: Mary McMaster Hallock Prize in Science -- for excellence in science as judged by the Health Professions
  • 2003: Fulbright Scolarship Recipient

Interests/Specialties:

  • Taste Receptor Signaling in the Intestinal Tract

Research Plan

  • Mentor: Charles Zuker, PhD
  • Sarah Taylor is working in the laboratory of Dr. Charles Zuker, PhD investigating the role of taste sensing in the mouse intestine. Much research has elucidated the taste signaling pathway in the tongue and more recently similar taste cells and receptors have been localized to the intestine. Sarah's research will focus on defining this unique population of cells within the mouse intestine and creating knockouts of various taste receptor cells (eg sweet, bitter, umami) in the gut. By subjecting these different knockouts to diets varying in fat content she will explore the hypothesis that mice deficient in taste sensing would have altered hormonal pathways leading to poor satiety and subsequent obesity with its co-morbidities.

 

 

Publications by Previous Fellows

Ekong UD, Mathew J, Melin-Aldana H, Wang D, Alonso EM. Successful resolution of inflammation and increased regulatory T cells in sirolimus-treated post-transplant allograft hepatitis. Pediatr Transplant. 2012 Mar;16(2):165-75

Feng S, Ekong UD, Lobritto SJ, Demetris AJ, Roberts JP, Rosenthal P, Alonso EM, Philogene MC, Ikle D, Poole KM, Bridges ND, Turka LA, Tchao NK. Complete immunosuppression withdrawal and subsequent allograft function among pediatric recipients of parental living donor liver transplants. JAMA. 2012 Jan 18;307(3):283-93

Ekong UD, Melin-Aldana H, Whitington PF. Regression of severe fibrotic liver disease in 2 children with neonatal hemochromatosis. J Pediatr Gastroenterol Nutr. 2008 Mar;46(3):329-33

Ekong U, Zeng S, Dun H, Feirt N, Guo J, Ippagunta N, Guarrera JV, Lu Y, Weinberg A, Qu W, Ramasamy R, Schmidt AM, Emond JC. Blockade of the receptor for advanced glycation end products attenuates acetaminophen-induced hepatotoxicity in mice. J Gastroenterol Hepatol. 2006 Apr;21(4):682-8

Ekong UD, Kelly S, Whitington PF. Disparate clinical presentation of neonatal hemochromatosis in twins. Pediatrics. 2005 Dec;116(6):e880-4

Cowles RA, Ventura KA, Martinez M, Lobritto SJ, Harren PA, Brodlie S, Carroll J, Jan DM. Reversal of intestinal failure-associated liver disease in infants and children on parenteral nutrition: experience with 93 patients at a referral center for intestinal rehabilitation. J Pediatr Surg. 2010 Jan;45(1):84-7; discussion 87-8.

Kato T, Lobritto SJ, Tzakis A, Raveh Y, Sandoval PR, Martinez M, Granowetter L, Armas A, Brown RS Jr, Emond J. Multivisceral Ex Vivo Surgery for Tumors Involving Celiac and Superior Mesenteric Arteries. Am J Transplant. 2012 May;12(5):1323-

Chapter 72 Postoperative Care of Pediatric Transplant Recipients sumitted to Busuttil & Klintmalm: Transplantation of the Liver, 3rd edition Mercedes Martinez, Steven Lobritto, Jean Emond. 2012

Remotti H, Subramanian S, Martinez M, Kato T, Magid MS. Small-bowel allograft biopsies in the management of small-intestinal and multivisceral transplant recipients: histopathologic review and clinical correlations. Arch Pathol Lab Med. 2012 Jul;136(7):761-71

Dapito DH, Mencin A, Gwak GY, Pradere JP, Jang MK, Mederacke I, Caviglia JM, Khiabanian H, Adeyemi A, Bataller R, Lefkowitch JH, Bower M, Friedman R, Sartor RB, Rabadan R, Schwabe RFPromotion of hepatocellular carcinoma by the intestinal microbiota and TLR4. Cancer Cell. 2012 Apr 17;21(4):504-16

Mencin A, Lavine JE. Advances in pediatric nonalcoholic fatty liver disease. Pediatr Clin North Am. 2011 Dec;58(6):1375-92

Mencin A, Lavine JE. Nonalcoholic fatty liver disease in children. Curr Opin Clin Nutr Metab Care. 2011 Mar;14(2):151-7

Mencin A, Kluwe J, Schwabe RF. Toll-like receptors as targets in chronic liver diseases. Gut. 2009 May;58(5):704-20

Mencin A, Seki E, Osawa Y, Kodama Y, De Minicis S, Knowles M, Brenner DA. Alpha-1 antitrypsin Z protein (PiZ) increases hepatic fibrosis in a murine model of cholestasis. Hepatology. 2007 Nov;46(5):1443-52.

Jung UJ, Millman PN, Tall AR, Deckelbaum RJn-3 fatty acids ameliorate hepatic steatosis and dysfunction after LXR agonist ingestion in mice. Biochim Biophys Acta. 2011 Sep;1811(9):491-7.

Srinivasan P, Brandler M, D'Souza A, Millman P, Moreau H. Allergic enterocolitis presenting as recurrent necrotizing enterocolitis in preterm neonates. J Perinatol. 2010 Jun;30(6):431-3

Radhakrishnan K, Bishop J, Jin Z, Kothari K, Bhatia M, George D, Garvin JH Jr, Martinez M, Ovchinsky N, Lobritto S, Elsayed Y, Satwani P.The Risk Factors Associated with Liver Injury and the Impact of Liver Injury on Transplant Related Mortality in Pediatric Recipients of Allogeneic Hematopoietic Stem Cell Transplantation. Biol Blood Marrow Transplant. 2013

Ovchinsky N, Moreira RK, Lefkowitch JH, Lavine JE. Liver biopsy in modern clinical practice: a pediatric point-of-view. Adv Anat Pathol. 2012 Jul;19(4):250-62.

Ovchinsky N, and Lavine, JE. A critical appraisal of advances in pediatric nonalcoholic Fatty liver disease. Semin Liver Dis. 2012 Nov;32(4):317-24

Ovchinsky N. Conjugated bile acids as potential early markers of parenteral nutrition-associated liver disease. JPEN J Parenter Enteral Nutr. 2010 Sep-Oct;34(5):473-4

Zhang B, Porto AF. Cholesteryl Ester Storage Disease: Protean Presentations of Lysosomal Acid Lipase Deficiency. J Pediatr Gastroenterol Nutr. 2013

Porto AF, Tormey L, Lim JK. Management of chronic hepatitis C infection in children. Curr Opin Pediatr. 2012 Feb;24(1):113-20

Munkacsi AB, Porto AF, Sturley SL. Niemann-Pick type C disease proteins: orphan transporters or membrane rheostats? Future Lipidol. 2007 Jun;2(3):357-367

Kaufman SS, Pehlivanova M, Fennelly EM, Rekhtman YM, Gondolesi GE, Little CA, Matsumoto CS, Fishbein TM. Predicting liver failure in parenteral nutrition-dependent short bowel syndrome of infancy. J Pediatr. 2010 Apr;156(4):580-5

Matsumoto CS, Kaufman SS, Girlanda R, Little CM, Rekhtman Y, Raofi V, Laurin JM, Shetty K, Fennelly EM, Johnson LB, Fishbein TM. Utilization of donors who have suffered cardiopulmonary arrest and resuscitation in intestinal transplantation. Transplantation. 2008 Oct 15;86(7):941-6

Ventura K, Rekhtman Y, Jan D, Emond J, Lobritto S. Isolated liver transplantation for decompensated end-stage liver disease in children with intestinal failure. Transplant Proc. 2006 Jul-Aug;38(6):1699-701

Devlin MJ, Kissileff HR, Zimmerli EJ, Samuels F, Chen BE, Brown AJ, Geliebter A, Walsh BT. Gastric emptying and symptoms of bulimia nervosa: effect of a prokinetic agent. Physiol Behav. 2012 May 15;106(2):238-42

Samuels F, Zimmerli EJ, Devlin MJ, Kissileff HR, Walsh BT. The development of hunger and fullness during a laboratory meal in patients with binge eating disorder. Int J Eat Disord. 2009 Mar;42(2):125-9

Suwandhi E, Ton MN, Schwarz SM. Gastroesophageal reflux in infancy and childhood. Pediatr Ann. 2006 Apr;35(4):259-66

Ton MN, Chang C, Carpentier YA, Deckelbaum RJ. In vivo and in vitro properties of an intravenous lipid emulsion containing only medium chain and fish oil triglycerides. Clin Nutr. 2005 Aug;24(4):492-501

Ton MN, Ruzal-Shapiro C, Stolar C, Kazlow PG. Recurrent sigmoid volvulus in a sixteen-year-old boy: case report and review of the literature. J Pediatr Surg. 2004 Sep;39(9):1434-

Garbarino J, Padamsee M, Wilcox L, Oelkers PM, D'Ambrosio D, Ruggles KV, Ramsey N, Jabado O, Turkish A, Sturley SL. Sterol and diacylglycerol acyltransferase deficiency triggers fatty acid-mediated cell death. J Biol Chem. 2009 Nov 6;284(45):30994-1005

Turkish AR, Sturley SL. The genetics of neutral lipid biosynthesis: an evolutionary perspective. Am J Physiol Endocrinol Metab. 2009 Jul;297(1):E19-27

Turkish A, Sturley SLRegulation of triglyceride metabolism. I. Eukaryotic neutral lipid synthesis: "Many ways to skin ACAT or a DGAT". Am J Physiol Gastrointest Liver Physiol. 2007 Apr;292(4):G953-7

Turkish AR. Nonalcoholic fatty liver disease: emerging mechanisms and consequences. Curr Opin Clin Nutr Metab Care. 2008 Mar;11(2):128-33

Turkish AR, Henneberry AL, Cromley D, Padamsee M, Oelkers P, Bazzi H, Christiano AM, Billheimer JT, Sturley SL. Identification of two novel human acyl-CoA wax alcohol acyltransferases: members of the diacylglycerol acyltransferase 2 (DGAT2) gene superfamily. J Biol Chem. 2005 Apr 15;280(15):14755-64