The Reporter: December 1997, Vol.8, No.5
Research notes
Preventing Latex Allergies

 P&S scientists have developed a topical hand cream that may prevent the two most common latex allergy reactions sensitization to latex after prolonged exposure and contact dermatitis. More than 1.4 million people in the United States are at risk for latex allergies, which cause itching and redness and, in severe cases, respiratory distress or even death.

 Researchers led by Dr. Shanta Modak, associate research scientist in the Department of Surgery, investigated topical creams containing a new gel composition for efficacy in preventing irritant dermatitis when used before wearing latex gloves. When the zinc gel composition is formulated in a special base, a gel matrix or a protective coating structure is formed on the skin's surface. The matrix appears to react with and bind soluble latex proteins and other irritants that produce allergies and may actually prevent the allergic response altogether. "This cream can prevent latex glove allergies for up to four hours when applied before putting on the gloves," says Dr. Modak. "Use of the cream may reduce health care workers' risk of becoming sensitized to latex after continued exposure and may help the tens of thousands of health care workers who suffer daily with chronic irritant dermatitis."

 Preliminary clinical evaluation indicates the cream is safe for use by the general public and for those who are not allergic to latex. Columbia University licensed the anti-irritant cream, called Allergy Guard, to Virasept Pharmaceuticals Inc.