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Gerard Karsenty, MD, PhD

  • Paul A. Marks Professor of Genetics and Development
  • Professor of Medicine
  • Chair, Genetics and Development
Gerard Karsenty, MD, PhD

For a variety of reasons our laboratory is pursuing the following questions: is bone an endocrine organ and if it is which physiological processes doe sit regulate? In addressing these questions we identified one hormone made by bone cells called osteocalcin and have shown that it exerts several functions in the brain. During embryogenesis, maternal osteocalcin crosses the placenta and prevents neuronal apoptosis in the hippocampus before the embryo can make osteocalcin. In adult mice, osteocalcin binds to neurons in the brainstem and the CA3 region of the hippocampus, favors the synthesis of all monoamine neurotransmitters and inhibits the synthesis of GABA. As a result adult Osteocalcin-/- mice display increased anxiety, and decreased spatial learning and memory. Current studies in the lab aim at identifying the receptor mediating these functions of osteocalcin with the dual goals to identify the molecular pathways regulated by this this hormone as well as other regions of the brain in which osteocalcin may signal. We are also studying the regulation of the activity of the autonomic nervous system by osteocalcin.

Departments and Divisions

  • Department of Genetics & Development
  • Department of Medicine
    Division of Endocrinology

Languages Spoken

  • French

Centers/Institutes/Programs

  • Herbert Irving Comprehensive Cancer Center

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Lab Locations

  • Hammer Health Sciences Building

    701 West 168th Street
    room 1602A
    New York, NY 10032
    Phone:
    (212) 305-6398
    Email:
    gk2172@cumc.columbia.edu

Research Interests

  • Cellular/Molecular/Developmental Neuroscience

NIH Grants

  • REGULATION OF GLUCOSE UPTAKE IN OSTEOBLASTS BY RUNX2 (Federal Gov)

    Sep 1 2015 - Jun 30 2020

    THE DIALOGUE BETWEEN BONE AND THE BRAIN: ENDOCRINE AND MOLECULAR BASES (Federal Gov)

    Aug 1 2010 - Apr 30 2020

    INNOVATIONS IN PROSTATE CANCER (Federal Gov)

    Nov 1 2015 - Oct 31 2017

    CHARACTERIZATION OF A RECEPTOR MEDIATING ADIPONECTIN FUNCTIONS ON BONE (Federal Gov)

    Sep 15 2015 - Aug 31 2016

    MOLECULAR BASES OF THE ANTI-AGING FUNCTIONS OF THE BONE DERIVED HORMONE OSTEOCALCIN (Private)

    Nov 1 2011 - Oct 31 2015

    OSTEOCALCIN: THE HORMONAL LINK BETWEEN BONE AND REPRODUCTION (Federal Gov)

    Jul 1 2010 - Jun 30 2015

    INTESTINAL SEROTONIN IN WHOLE BODY ENERGY METABOLISM (Federal Gov)

    Jul 1 2013 - Jun 30 2014

    LRP5-DEPENDENT REGULATION OF BONE MASS ACCRUAL BY GUT-DERIVED SEROTONIN (Federal Gov)

    Jul 1 2009 - May 31 2014

    SEROTONIN IN WHOLE BODY ENERGY METABOLISM (Private)

    May 4 2012 - May 3 2014

    OSTEOCALCIN AS A MULTIFUNCTIONAL HORMONE (Private)

    Feb 18 2011 - Feb 17 2014

    REGULATION OF GLUCOSE METABOLISM BY BONE RESORPTION (Private)

    Jul 1 2011 - Jun 30 2013

    OSTEOCALCIN AS A REGULATOR OF ENERGY METABOLISM (Federal Gov)

    Apr 1 1998 - Apr 30 2013

    THE FIAT-AFF4 INTERACTION AND THE CONTROL OF BONE MASS (Federal Gov)

    Aug 1 2006 - Jul 31 2011

    LEPTIN AS A REGULAR OF BONE MASS (Federal Gov)

    May 1 2006 - Jun 30 2011

    GUT - DERIVED SEROTONIN AS A MEDIATOR OF IRP5 REGULATION OF BONE MASS (Private)

    Jul 1 2006 - May 31 2011

    REGULATION OF ENERGY METABOLISM BY AN OSTEOBLAST-SPECIFIC GE NE (Federal Gov)

    May 5 2007 - Apr 30 2011

Publications

1: Lee NK, Sowa H, Hinoi E, Ferron M, Ahn JD, Confavreux C, Dacquin R, Mee PJ, McKee MD, Jung DY, Zhang Z, Kim JK, Mauvais-Jarvis F, Ducy P, Karsenty G. Endocrine regulation of energy metabolism by the skeleton. Cell. 2007 Aug 10;130(3):456-69. 

2: Ferron M, Wei J, Yoshizawa T, Del Fattore A, DePinho RA, Teti A, Ducy P, Karsenty G. Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism. Cell. 2010 Jul 23;142(2):296-308. doi:10.1016/j.cell.2010.06.003. 

3: Oury F, Sumara G, Sumara O, Ferron M, Chang H, Smith CE, Hermo L, Suarez S, Roth BL, Ducy P, Karsenty G. Endocrine regulation of male fertility by the skeleton. Cell. 2011 Mar 4;144(5):796-809. doi: 10.1016/j.cell.2011.02.004. Epub 2011 Feb 17.

4: Oury F, Khrimian L, Denny CA, Gardin A, Chamouni A, Goeden N, Huang YY, Lee H, Srinivas P, Gao XB, Suyama S, Langer T, Mann JJ, Horvath TL, Bonnin A, Karsenty, G. Maternal and offspring pools of osteocalcin influence brain development and functions. Cell. 2013 Sep 26;155(1):228-41. doi: 10.1016/j.cell.2013.08.042.