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Domenico Accili, MD

  • Russell Berrie Foundation Professor of Diabetes (in Medicine)
Domenico Accili, MD

Dr. Domenico Accili is Professor of Medicine at Columbia University and Director of the Columbia University Diabetes and Endocrinology Research Center in New York City. A graduate of the University of Rome, his training in Internal Medicine was served at the University Hospital Gemelli, also in Rome. Following a Fogarty Fellowship in the Diabetes Branch of the National Institute of Diabetes and Digestive Kidney Diseases, he became Chief of the Section on Genetics and Hormone action of the National Institute of Child Health at the National Institutes of Health in Bethesda, Maryland. Since 1999, he has served on the faculty at Columbia University College of Physicians & Surgeons and as an Attending Physician at Columbia-Presbyterian Hospital.&

Dr. Accili's research has delved into the pathogenesis of diabetes, the integrated physiology of insulin action and mechanisms of pancreatic beta dysfunction. He is best known for the identification of a family of DNA-binding proteins that collectively regulate diverse pathophysiological processes, including liver glucose and lipid production, food intake, insulin production and adipogenesis. He has received numerous awards, including the 2003 Lilly Award for Outstanding Scientific Achievement by the American Diabetes Association. His work has been published in leading medical research journals. He has served on several editorial boards, including the Journal of Clinical Investigation and Diabetes. He is a member of numerous advisory panels for academia, government and industry. He is an elected member of the Association of American Physicians and the American Society for Clinical Investigation. His work is supported by the National Institutes of Health, the American Diabetes Association, the Russ Berrie Foundation, and the Brehm Coalition.

Departments and Divisions

  • Department of Medicine
    Division of Endocrinology

Education & Training

  • University of Cattolica, Italy
  • Fellowship: National Institutes of Health

Committees / Societies / Memberships

Advisory Board, Diabetes Gene Discovery Group, Genome Canada

Honors & Awards

  •     Association of American Physicians
  •     American Society for Clinical Investigation
  •     Member, Metabolism Study Section
  •     Advisory Board, NIDDK Beta Cell Biology Consortium
  •     Advisory Board, Congressional Special Statutory Funding Program for Type 1 Diabetes Research
  •     Molecular and Cellular Endocrinology Study Section
  •     Chair, Beta Cell Group, Diabetes Research Strategic Plan, NIDDK
  •     Member, NIDDK Council
  •     MERIT Award, NIDDK, NIH

Research Interests

  • The Accili laboratory studies the mechanism of insulin action and the pathogenesis of diabetes, with a focus on pancreatic beta cell failure

NIH Grants

  • MECHANISMS OF BETA CELL FAILURE (Federal Gov)

    Jun 15 2017 - May 31 2021

    CHARACTERIZING THE DEDIFFERENTIATING BETA CELL IN DIABETES (Federal Gov)

    Sep 15 2016 - Sep 14 2020

    ROLE OF FORKHEAD PROTEINS IN INSULIN ACTION (Federal Gov)

    Jun 1 2000 - Dec 31 2019

    BETA CELL DIFFERENTIATION AS A DIABETES TREATMENT (Private)

    Sep 1 2015 - Jun 30 2018

    DIABETES AND ENDOCRINOLOGY RESEARCH CENTER (Federal Gov)

    Mar 15 2013 - Jan 31 2018

    MECHANISMS OF ATHEROGENESIS IN INSULIN RESISTANCE (Federal Gov)

    Feb 1 2013 - Jan 31 2018

    DIACOMPSUMMER STUDENT FUNDING PROGRAM (Federal Gov)

    May 1 2017 - Jul 31 2017

    THE ROLE OF FOXO1 IN THE REGULATION OF THE ADIPOCYTE BROWNING RESPONSE (Federal Gov)

    Aug 1 2013 - Jul 31 2017

    MERCK-COLUMBIA (ACCILI) INSULIN SENSITZER AND BETA CELL DEDIFFERENTIATION COLLABORATION (Private)

    Dec 14 2015 - Dec 13 2016

    GPR17 FUNCTION IN METABOLISM AND SATIETY CONTROL (Federal Gov)

    Sep 1 2014 - Aug 31 2016

    DIACOMP SUMMER STUDENT FUNDING PROGRAM (Federal Gov)

    Jun 1 2016 - Aug 28 2016

    BROWN REMODELING OF WHITE ADIPOSE TISSUE BY PPARGAMMA DEACETYLATION (Federal Gov)

    Aug 15 2013 - Aug 14 2016

    SERVIER FELLOWSHIP IN INNOVATIVE DIABETES RESEARCH (Private)

    Jul 16 2015 - Jul 15 2016

    AZ IDENTIFY FOX01 INHIBITORS/BLOCKERS THAT PROMOTE ENTEROENDOCRINE CELL DIFFERENTIATION INTO INSULIN-PRODUCING CELLS (Private)

    Apr 30 2014 - Dec 31 2015

    USE OF HUMAN IPS-DERIVED GUT ORGANOIDS TO CARRY OUT PHENOTYPIC SCREENS FOR INDUCTION OF HORMONE-PRODUCING CELLS (Private)

    Apr 1 2014 - Dec 31 2015

    DIACOMPSUMMER STUDENT FUNDING PROGRAM (Federal Gov)

    Jun 1 2015 - Sep 30 2015

    EPGENETIC, PROTEIN, AND CELLULAR BIOMARKERS OF BETA CELL FUNCTION IN T1D (Federal Gov)

    Sep 18 2014 - Aug 31 2015

    BETA CELL DIFFERENTIATION AS A DIABETES TREATMENT (Private)

    Jan 1 2013 - Aug 31 2015

    MERCK-COLUMBIA INSULIN SENSITIZER NEW TARGET COLLABORATION (Private)

    Jul 8 2014 - Jul 7 2015

    ROLE OF GLUT4-EXPRESSING NEURONS IN DIABETES (Private)

    Jul 1 2011 - Jun 30 2015

    MERCK-COLUMBIA INSULIN SENSITIZER NEW TARGET COLLABORATION (Private)

    Dec 3 2012 - Dec 2 2014

    DIACOMPSUMMER STUDENT FUNDING PROGRAM (Federal Gov)

    Jun 1 2014 - Sep 30 2014

    AMGEN RESEARCH COLLABORATION AGREEMENT (Private)

    Dec 6 2012 - Dec 5 2013

    BREHM COALITION AWARD (Private)

    Dec 1 2008 - Nov 30 2013

    INSULIN ACTION ON GLUT4 AND FOXO1 IN THE BRAIN (Federal Gov)

    Sep 1 2012 - Aug 31 2013

    REPROGRAMMING GUT INSULIN-PRODUCING CELLS (Private)

    Mar 1 2010 - Feb 29 2012

    NOTCH1-FOX01 INTERACTION IN REGULATION OF HEPATIC GLUCONEOGE NESIS (Federal Gov)

    Jul 1 2009 - Jul 2 2011

    TRANSCRIPTIONAL REGULATION IN DIABETS (Private)

    Jul 1 2007 - Jun 30 2011

    ROLE OF HEPATIC FOXO1 IN ATHEROSCLEROSIS (Federal Gov)

    Sep 13 2010 - May 15 2011