The Irving Center for Clinical Research (ICCR), including the NIH-funded General Clinical Research Center, has excellent facilities and services to support clinical research. Faculty members from Dentistry, Medicine, Nursing, Public Health, and investigators from the New York State Psychiatric Institute conduct multidisciplinary investigations of human disease and clinical pharmacology. Major foci of research relate to areas such as cancer, lipids and lipoprotein metabolism, obesity, neurology (Parkinson's disease, Alzheimer's disease, stroke, neonatal brain damage), cardiovascular disease, endocrine disorders (hyperparathyroidism, diabetes mellitus), and psychiatric conditions (substance abuse, depression, schizophrenia). In addition, the center serves research protocols in many other areas. The ICCR fosters training of young clinical investigators through seminar series, courses and mentoring.
ICCR facilities occupy more than 30,000 square feet of space on adjacent floors in Medical Center buildings. An Adult Inpatient Unit has 16 private rooms. The separate Outpatient Unit has five rooms for interviews, examination, and treatment. There are separate pediatric inpatient and outpatient units. A core laboratory performs specialized research assays of all kinds. A data management unit assists investigators in the design of experiments and the analysis of the resulting data and advises on data management issues. The Nutrition Unit collaborates in the design and analysis of research protocols, provides nutritional counseling, and prepares nutrient-controlled meals for study diets.
Naomi Berrie Diabetes Center
The Naomi Berrie Diabetes Center at Columbia Presbyterian was opened in October 1998. The Center offers state-of-the-art multidisciplinary clinical care for the patient with diabetes mellitus. Comprehensive services are offered for patients of all ages and with all types of diabetes. Care is coordinated by pediatric and adult endocrinologists, assisted by nurse educators, nutritionists, family therapists, opthalmologists, exercise specialists, surgeons, and podiatrists.
The Center also includes basic and clinical research activities conducted within the Centers 5,000 square feet of research space adjacent to the clinical facilities, and in laboratories of investigators affiliated with the Center. Areas of investigation include metabolic homeostasis in human obesity, molecular genetics of obesity and diabetes in rodents and humans, molecular physiology of insulin resistance, molecular biochemistry of glycosylation in diabetes complications, immunology of islet transplantation, and dyslipidemias related to diabetes mellitus.
Obesity Research Center
The Obesity Research Center at St. Luke's–Roosevelt Medical Center is designed to provide both the leadership and the administrative matrix for fostering productive cooperation among participating investigators. The main thrust of investigation at the Center is the study of the relationship between food intake regulation and adipose tissue, the calorie storage depot. Studies range from the morphology and biochemistry of the adipocyte to the psychological and social aspects of food intake, and from the earliest development of adipocytes to the late, adult consequences of obesity. In all instances, the studies are devoted to further the understanding of fundamental biology of calorie intake and storage, and the principal calorie disorder in humans, obesity.
A major contribution of the Obesity Research Center is the training of graduate students, postdoctoral fellows, and clinical investigators in subject areas pertinent to obesity.