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Faculty and Staff

Nutritional and Metabolic Biology Doctoral Training Faculty

 

 Yiping W. Han, Ph.D.
Professor of Microbial Sciences in Dental Medicine and Microbiology & Immunology
 ywh2102@columbia.edu

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Degrees

PhD 1993, University of Illinois at Urbana-Champaign

Research

1. Investigating the role of oral bacteria in extra-oral infection and inflammation.
2. Investigating the mechanisms of Fusobacterium nucleatum pathogenesis in pregnancy complications and colorectal cancer.
3. Developing genetic tools for mutant construction in bacteria.

Publications - PubMed

• Han, Y.W. (2015) Fusobacterium nucleatum: a commensal-turned pathogen. Curr. Opin. Microbiol. 23C:141-147.
• Han, Y.W. (2014) Oral bacteria as drivers for colorectal cancer. J. Periodontol. 85: 1155-1157.
• Rubinstein, M.R., Wang, Y., Liu, W., Hao, Y., Cai, G. and Han, Y.W. (2013) Fusobacterium nucleatum promotes colorectal carcinogenesis by modulating E-cadherin/beta-catenin signaling via its FadA adhesin. Cell Host & Microbe 14: 195-206.
• Han, Y.W. and Wang, X. (2013) Mobile microbiome: oral bacteria in extra-oral infections and inflammation. J. Dent. Res. 92: 485-491.
• Fardini, Y., Wang, X., Temoin, S., Nithianantham, S., Lee, D., Shoham, M. and Han Y.W. (2011) Fusobacterium nucleatum adhesin FadA binds vascular-endothelial cadherin and impairs endothelial integrity. Mol. Microbiol. 82: 1468-1480.
• Han, Y.W. (2011) Can oral bacteria cause pregnancy complications? Women's Health 7: 401-404.
• Han, Y.W. (2011) Oral health and adverse pregnancy outcomes - what's next? J. Dent. Res. 90: 289-293.
• Fardini, Y., Chung, P., Joshi, N. and Han, Y.W. (2010) Transmission of diverse oral bacteria to murine placenta: evidence of oral microbiome as a source of intrauterine infection. Infect. Immun. 78: 1789-1796.
• Han, Y.W., Fardini, Y., Chen, C., Iacampo, K.G., Peraino, V.A., Shamonki, J.M. and Redline, R.W. (2010) Term stillbirth caused by oral Fusobacterium nucleatum. Obstet. Gynecol. 115: 442-445.
• Ikegami, A., Chung, P. and Han, Y.W. (2009) Complementation of the fadA mutation in Fusobacterium nucleatum demonstrates that the surface-exposed adhesin promotes cellular invasion and placental colonization. Infect. Immun. 77: 3075-3079.
• Han, Y.W., Shen, T., Chung, P., Buhimschi, I.A. and Buhimschi, C.S. (2009) Uncultivated bacteria as etiologic agents of intra-amniotic inflammation leading to preterm birth. J. Clin. Microbiol. 47: 38-47.
• Nithianantham, S., Xu, M., Ikegami, A., Yamada, M., Shoham, M. and Han, Y W. (2009) Crystal structure of FadA adhesin from Fusobacterium nucleatum reveals a novel oligomerization motif, the leucine chain. J. Biol. Chem. 284: 3865-3872.
• Xu, M., Yamada, M., Li, M., and Chen, S.G. and Han, Y.W. (2007) FadA from Fusobacterium nucleatum utilizes both secreted and nonsecreted forms for functional oligomerization for attachment and invasion of host cells. J. Biol. Chem. 282: 25000-25009.
• Liu, H., Redline, R. and Han, Y.W. (2007) Fusobacterium nucleatum induces fetal death in mice via stimulation of TLR4-mediated placental inflammatory response. J. Immunol. 179: 2501-2508.
• Han, Y.W., Ikegami, A., Chung, P., Zhang, L., Zhou, Y. and Deng, D.X. (2007) Sonoporation is an efficient tool for intracellular fluorescent dextran delivery and one-step double-crossover mutant construction in Fusobacterium nucleatum. Appl. Environ. Microbiol. 73: 3677-3683.
• Han, Y.W., Ikegami, A., Bissada, N., Herbst, M., Redline, R.W. and Ashmead, G.G. (2006) Transmission of an uncultivated Bergeyella strain from the oral cavity to amniotic fluid in a case of preterm birth. J. Clin. Microbiol. 44: 1475-1483.
• Han, Y.W., Ikegami, A., Rajanna, C, Kawsar, H.I., Zhou. Y., Li, M., Sojar, H., Genco, R.J., Kuramitsu, H.K. and Deng, C. X. (2005) Identification and characterization of a novel adhesin unique to oral fusobacteria. J. Bacteriol. 187: 5330-5340.
Han, Y.W., Redline, R.W., Li, M., Yin, L., Hill, G.B. and McCormick, T.S. (2004) F. nucleatum induces premature and term stillbirths in pregnant mice: implication of oral bacteria in preterm birth. Infect. Immun. 72: 2272-2279.

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