The Institute Of Human Nutrition

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Faculty and Staff

Nutritional and Metabolic Biology Doctoral Training Faculty


Wellington V. Cardoso, MD, PhD
Professor of Medicine and Genetics & Development
Director, Columbia Center for Human Development

Education and Training

MD 1981, University of Brasilia, Brazil
PhD 1984, University of Sao Paulo, Brazil

Research Interests

Research in the Cardoso’s lab focuses on the mechanisms that regulate lung progenitor cell fate during lung development and on the contribution of developmental mechanisms to disease pathogenesis and regeneration-repair of the adult lung. We are investigating how progenitor cells generate the wide diversity of cell types of the mature respiratory system. In this context, we have been identifying early markers of cell fate and characterizing the genetic programs associated with acquisition of the various airway epithelial cell phenotypes as the lung forms. These studies have provided insights into the role of specific pathways, including retinoids, Fgf, Tgf beta and Notch in controlling the specification and expansion of lung progenitors, airway branching and differentiation of the various lung epithelial cell lineages. Over these years our studies have evolved to continue exploring basic mechanisms of lung development, using this knowledge to understand the role of stem/progenitor cells in lung regeneration-repair and the impact of prenatal fetal exposures in adult lung structure and function and susceptibility to disease.

Publications - PubMed

1 Chen F, Cao Y, Qian J, Shao F, Niederreither K, Cardoso WV. A retinoic acid-dependent network in the foregut controls formation of the mouse lung primordium. J. Clin. Invest.120:2040-8. 2010 PMID: 20484817
2 Tsao PN, Vasconcelos M, Izvolsky KI, Qian J, Lu J, Cardoso WV. Notch signaling controls the balance of ciliated and secretory cell fates in developing airways. Development 136: 2297-2307, 2009. PMID: 19502490
3 Shi W, Chen F, Cardoso WV. Mechanisms of lung development: contribution to adult lung disease and relevance to chronic obstructive pulmonary disease. Proc. Am. Thor. Soc. , 6:558-63. 2009. PMID: 19934349
4 Izvolsky KI, Lu J, Martin G, Albrecht K, and Cardoso WV. Systemic inactivation of Hs6st1 in mice is associated with late postnatal mortality without major defects in organogenesis. Genesis 46:8-18, 2008. PMID: 18196599
5 Chen F., Desai T., Qian J., Niederreither K., Lu J, and Cardoso WV. Inhibition of Tgf beta signalling by endogenous retinoic acid is essential for primary lung bud induction Development 134: 2969-2979, 2007. PMID: 17634193
6 Lü J, Qian J, Keppler D, Cardoso WV. Cathespin H is an FGF10 Target Involved in BMP4 Degradation during Mouse Lung Branching Morphogenesis J. Biol Chem 282:22176–22184, 2007. PMID: 17500053
7 Desai T, Chen F., Lu J, Qian J, Niederreither K., Dollé, P., Chambon, P., and Cardoso WV. Distinct roles for retinoic acid receptors alpha and beta in early lung morphogenesis. Dev. Biol., 291:12-24, 2006.
8 Cardoso, WV and Lu, J. Regulation of early lung development: questions, facts and controversies. Development 133: 1161-1624, 2006. PMID: 16613830
9 Cardoso WV, Kotton DN. Specification and patterning of the respiratory system. StemBook, ed. The Stem Cell Research Community, StemBook, doi/10.3824/stembook.1.10.1 2008. PMID: 20614584.


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