The Institute Of Human Nutrition
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Faculty & Staff

Doctoral Training and Teaching Faculty

        Alan R. Tall, M.D.

        Tilden Weger Bieler Professor of Medicine

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P & S Room 8-401
630 West 168th St.
New York, NY 10032
Phone: 212-305-4899

 

Degrees

M.D. 1970, University of Sydney, Sydney, Australia

 

Research Interests

The laboratory is carrying out research on the molecular mechanisms responsible for human diseases. The approach is to use molecular, genomic and cellular approaches to investigate basic aspects of the pathogenesis of atherosclerosis. A major focus is on molecular mechanisms of cellular cholesterol efflux, mediated by the interaction of extracellular apoA-I with the lipid transporter ABCA1. We are carrying out studies on the transcriptional regulation of ABCA1 gene expression, and regulation of the degradation of ABCA1 protein. This has led to the elucidation of a class of transcription factors (LXRs) that co-ordinately regulate cellular cholesterol efflux and reverse cholesterol transport.

Recent Publications - Pubmed

Association of antibody responses to the conserved Plasmodium falciparum merozoite surface protein 5 with protection against clinical malaria.
Perraut R, Joos C, Sokhna C, Polson HE, Trape JF, Tall A, Marrama L, Mercereau-Puijalon O, Richard V, Longacre S. PLoS One. 2014 Jul 21;9(7):e101737. doi: 10.1371/journal.pone.0101737.  

The rise and fall of malaria in a West African rural community, Dielmo, Senegal, from 1990 to 2012: a 22 year longitudinal study.
Trape JF, Tall A, Sokhna C, Ly AB, Diagne N, Ndiath O, Mazenot C, Richard V, Badiane A, Dieye-Ba F, Faye J, Ndiaye G, Diene Sarr F, Roucher C, Bouganali C, Bassène H, Touré-Baldé A, Roussilhon C, Perraut R, Spiegel A, Sarthou JL, da Silva LP, Mercereau-Puijalon O, Druilhe P, Rogier C.  Lancet Infect Dis. 2014 Jun;14(6):476-88. doi: 10.1016/S1473-3099(14)70712-1.

Adipose tissue macrophages promote myelopoiesis and monocytosis in obesity.
Nagareddy PR, Kraakman M, Masters SL, Stirzaker RA, Gorman DJ, Grant RW, Dragoljevic D, Hong ES, Abdel-Latif A, Smyth SS, Choi SH, Korner J, Bornfeldt KE, Fisher EA, Dixit VD, Tall AR, Goldberg IJ, Murphy AJ.  Cell Metab. 2014 May 6;19(5):821-35. doi: 10.1016/j.cmet.2014.03.029.

Raltegravir for the treatment of patients co-infected with HIV and tuberculosis (ANRS 12 180 Reflate TB): a multicentre, phase 2, non-comparative, open-label, randomised trial.
Grinsztejn B, De Castro N, Arnold V, Veloso VG, Morgado M, Pilotto JH, Brites C, Madruga JV, Barcellos NT, Santos BR, Vorsatz C, Fagard C, Santini-Oliveira M, Patey O, Delaugerre C, Chêne G, Molina JM; ANRS 12 180 Reflate TB study group.  Lancet Infect Dis. 2014 Jun;14(6):459-67. doi: 10.1016/S1473-3099(14)70711-X.

Disruption of mammalian target of rapamycin complex 1 in macrophages decreases chemokine gene expression and atherosclerosis.
Ai D, Jiang H, Westerterp M, Murphy AJ, Wang M, Ganda A, Abramowicz S, Welch C, Almazan F, Zhu Y, Miller YI, Tall AR.  Circ Res. 2014 May 9;114(10):1576-84. doi: 10.1161/CIRCRESAHA.114.302313.

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Contact Us

630 West 168th Street
Presbyterian Hospital,
Suite 1512
New York, NY 10032
Tel: 212 305-4808
Fax: 212 305-3079
Email: nutrition@cumc.columbia.edu

IHN

Ph.D. Faculty Research

M.S. Faculty Research