Faculty & Staff
Doctoral Training and Teaching Faculty
Ravichandran Ramasamy, Ph.D.
Associate Professor of Medicine, NYU
B.S. 1985, Loyola College, Madras, India
Ph.D. 1989, Loyola University of Chicago, Illinois
The primary focus of Dr. Ramasamy's research effort has been to understand the metabolic basis of ischemic injury and heart failure. This has led to a novel finding that the glucose metabolizing enzyme aldose reductase, a rate limiting enzyme in the polyol pathway, assumes a critical role in the pathogenesis of myocardial ischemic injury. To further understand the role of aldose reductase in ischemic injury and in heart failure, the Ramasamy laboratory has initiated studies with transgenic mice overexpressing human aldose reductase. Therapeutic agents that inhibit aldose reductase are being investigated for protection of ischemic myocardium. Furthermore, research projects addressing the role of aldose reductase and its inhibition on the outcome of the balloon injury model of restenosis and diabetic heart disease are in progress. Another area of research addresses the role of aldose reductase and sorbitol dehydrogenase in generating advanced glycation end-products (AGEs) in diabetic hearts. They have demonstrated that a precursor of AGEs, 3-deoxyglucosone (3-DG), is generated by aldose reductase pathways and that superimposition of ischemia on diabetics leads to exaggerated changes in AGEs and its receptor (RAGE) expression, leading to increased mortality. Studies have been initiated in transgenic mice to determine the role of aldose reductase and RAGE in mediating increased cardiac complications and mortality due to diabetes.
Recent Publications - Pubmed
L. G. Bucciarelli, R. Ananthakrishnan, Y. C. Hwang, M. Kaneko, F. Song, D. R. Sell, C. Strauch, V. M. Monnier, S. F. Yan, A. M. Schmidt, R. Ramasamy. RAGE & Modulation of Ischemic Injury In The Diabetic Myocardium. Diabetes 2008, 57: 1941-1951.
Q. Li, Y.C. Hwang, R. Ananthakrishnan, P.J. Oates, D. Guberski, R. Ramasamy. Polyol pathway and modulation of ischemia-reperfusion injury in Type 2 diabetic BBZ rat hearts. Cardiovascular Diabetology 2008, 7 : 33.
R. Ananthakrishnan, M. Kaneko, Y.C. Hwang, Gomes T., Caspersen C., Ramasamy R. Aldose Reductase Mediates Myocardial Ischemia-Reperfusion Injury in Part By Opening Mitochondrial Permeability Transition Pore. American Journal of Physiology: Heart & Circulatory Physiology 2009; 296 : H333-H341.