Faculty and Staff
Nutritional and Metabolic Doctoral Training Faculty
Michael D. Gershon, M.D.
Professor of Pathology and Cell Biology
B.A. 1958, Cornell University
M.D. 1963, Cornell University
Organization and development of the enteric nervous system.
Our research is focused on the enteric nervous system (ENS), the intrinsic innervation of the bowel. This is the only part of the peripheral nervous system that is capable of mediating reflex behavior in the absence of input from the brain or spinal cord. Our goals are to understand the organization of the two neural plexuses that comprise the ENS, and to determine how enteric microcircuits and the activity of individual neurons within these circuits control the primitive motile, secretory, and absorptive behaviors of the gut. We have devised novel techniques to study enteric microcircuits. In addition to electrophysiology, these include optical imaging techniques with probes that permit neuronal activity to be assessed and neuronal connections to be identified. We also study the cellular biology and function of serotonin in initiating enteric reflexes and signaling to the brain. These studies include the analysis of the behavior of the gut in transgenic mice that lack individual subtypes of serotonin receptor and/or the transporter molecule that is primarily responsible for the inactivation of serotonin within the bowel.
In additon to studies of the adult ENS, we are investigating its development. The ENS is known to be derived from precursors that migrate to the gut from the neural crest. We are currently identifying the molecular signals (guidance molecules and growth factors) utilized by to migrate correctly from their neural crest origin to their final destinations in the bowel, to stop migrating when they reach these destinations, and what microenvironmental cues help to influence the phenotypic expression of neural and glial precursors within the ENS. This work involves tissue and organ culture, the construction of chick-quail interspecies chimeras, and work on the molecular basis of a defect in a mutant strain of mouse that causes a segment of bowel not to be colonized by crest-derived precursors.
Recent Publications - Pubmed
Gershon MD. Enteric serotonergic neurones ... finally! J Physiol. 2009 Feb 1;587(Pt 3):507
Bischoff SC, Mailer R, Pabst O, Weier G, Sedlik W, Li Z, Chen JJ, Murphy DL, Gershon MD. Role of serotonin in intestinal inflammation: knockout of serotonin reuptake transporter exacerbates 2,4,6-trinitrobenzene sulfonic acid colitis in mice.
Am J Physiol Gastrointest Liver Physiol. 2009 Mar;296(3):G685-95. Epub 2008 Dec 18.
Welch MG, Tamir H, Gross KJ, Chen J, Anwar M, Gershon MD. Expression and developmental regulation of oxytocin (OT) and oxytocin receptors (OTR) in the enteric nervous system (ENS) and intestinal epithelium. J Comp Neurol. 2009 Jan 10;512(2):256-70.
Chalazonitis A, Pham TD, Li Z, Roman D, Guha U, Gomes W, Kan L, Kessler JA, Gershon MD. Bone morphogenetic protein regulation of enteric neuronal phenotypic diversity: relationship to timing of cell cycle exit. J Comp Neurol. 2008 Aug 10;509(5):474-92.