Faculty & Staff
Doctoral Training and Teaching Faculty
Harry R. Kissileff, Ph.D.
Associate Professor of Clinical Psychology (in Psychiatry and Medicine)
B.A. 1962, University of Pennsylvania
Ph.D. 1966, University of Pennsylvania
The main focus of the Kissileff laboratory is to develop an understanding of the various controls of food intake in humans. Currently, his laboratory is investigating: (1) The role of the gut in the development of satiety. They have shown that some hormones, such as cholecystokinin (CCK), but not others, such as insulin, reduce food intake when these are given intravenously before and during a meal. They have shown that a full stomach increases one's sensitivity to the intake-reducing effect of CCK. They also have demonstrated differences between men and women in the effects of CCK and fullness of the stomach on reduction of food intake. (2) Disturbances in eating behavior in patients with eating disorders and their physiological basis. In collaboration with B. T. Walsh studies are being conducted on rates of eating and rate of change in feelings associated with eating. Patients with eating disorders are both more and less sensitive than controls to the satiating effects of foods, depending on how much has been eaten and the instructions and rate of eating. Levels of CCK are lower in patients with bulimia and their gastric emptying is slower. The reduced level of CCK appears not be secondary to reduced gastric emptying. (3) Controls of food intake in pre-school children. Analog scaling devices similar to those in adults are being developed to test the hypothesis that overweight preschool children are less sensitive to the satiating effects and more sensitive to the intake enhancing effects of foods. (4) Effects of leptin and weight loss in obese patients. In collaboration with Rudy Leibel, studies are being done on eating rates and amounts eaten in ad libitum meals as well as ratings of fullness and other sensations during fixed sized meals in patients after weight loss and following treatment with leptin.
Recent Publications - Pubmed
Walsh BT. Zimmerli E. Devlin MJ. Guss J. Kissileff HR. A disturbance of gastric function in bulimia nervosa. Biological Psychiatry 54:929-33, 2003.
Kissileff HR. Carretta JC. Geliebter A. Pi-Sunyer FX. Cholecystokinin and stomach distension combine to reduce food intake in humans. American Journal of Physiology - Regulatory Integrative & Comparative Physiology 285:R992-8, 2003.
Nolan LJ, Guss JL, Liddle RA, Pi-Sunyer FX, Kissileff HR. Elevated plasma cholecystokinin and appetitive ratings after consumption of a liquid meal in humans. Nutrition 19:553-557, 2003.