Faculty and Staff
Nutritional and Metabolic Doctoral Training Faculty
Angela M. Christiano, Ph.D.
Associate Professor, Departments of Dermatology and Genetics & Development
Director of Basic Science Research, Department of Dermatology
B.A. 1987, Douglas College, New Brunswick
M.S. 1990, Rutgers University
Ph.D. 1991, Rutgers University
The major focus of Dr. Christiano's lab is the study inherited skin and hair disorders in humans, through a broad-based approach including genetic linkage, gene discovery and mutation analysis, and most recently, functional studies relating these findings back to basic questions in epidermal biology. Molecular aspects of the cutaneous basement membrane zone, adhesion junctions including hemidesmosomes and desmosomes, and epidermal appendages such as hair and teeth, are strong basic science interests in the laboratory. One long-range goal of the lab's research is to develop rationally designed genetic therapies for skin and hair diseases through understanding the underlying pathogenetic mechanisms. Dr. Christiano's group is also exploring the role of retinoid signaling during epidermal development and differentiation using mouse models. In particular, she is studying the potential interactions of the RXR-alpha gene with hairless and is identifying targets of retinoic acid and its receptors in the skin, using microarray profiling.
Recent Publications - Pubmed
Christiano AM. Epithelial stem cells: stepping out of their niche. Cell 118:530-2, 2004.
Jahoda CA, Kljuic A, O'Shaughnessy R, Crossley N, Whitehouse CJ, Robinson M, Reynolds AJ, Demarchez M, Porter RM, Shapiro L, Christiano AM. The lanceolate hair rat phenotype results from a missense mutation in a calcium coordinating site of the desmoglein 4 gene. Genomics 83:747-56, 2004.
Kljuic A, Bazzi H, Sundberg JP, Martinez-Mir A, O'Shaughnessy R, Mahoney MG, Levy M, Montagutelli X, Ahmad W, Aita VM, Gordon D, Uitto J, Whiting D, Ott J, Fischer S, Gilliam TC, Jahoda CA, Morris RJ, Panteleyev AA, Nguyen VT, Christiano AM. Desmoglein 4 in hair follicle differentiation and epidermal adhesion. Evidence from inherited hypotrichosis and acquired pemphigus vulgaris. Cell 113:249-260, 2003.