Faculty and Staff
Nutritional and Metabolic Biology Doctoral Training Faculty
Domenico Accili, M.D.
Professor of Medicine
Russ Berrie Pavilion
1150 St.Nicholas Avenue
New York, NY 10032
M.D. 1983, University of Rome, Italy
The Accili laboratory studies the mechanism of insulin action and the pathogenesis of diabetes, with a focus on pancreatic beta cell failure
Dr. Domenico Accili is Professor of Medicine at Columbia University and Director of the Columbia University Diabetes and Endocrinology Research Center in New York City. A graduate of the University of Rome, his training in Internal Medicine was served at the University Hospital Gemelli, also in Rome. Following a Fogarty Fellowship in the Diabetes Branch of the National Institute of Diabetes and Digestive Kidney Diseases, he became Chief of the Section on Genetics and Hormone action of the National Institute of Child Health at the National Institutes of Health in Bethesda, Maryland. Since 1999, he has served on the faculty at Columbia University College of Physicians & Surgeons and as an Attending Physician at Columbia-Presbyterian Hospital.
Dr. Accili’s research has delved into the pathogenesis of diabetes, the integrated physiology of insulin action and mechanisms of pancreatic beta dysfunction. He is best known for the identification of a family of DNA-binding proteins that collectively regulate diverse pathophysiological processes, including liver glucose and lipid production, food intake, insulin production and adipogenesis. He has received numerous awards, including the 2003 Lilly Award for Outstanding Scientific Achievement by the American Diabetes Association. His work has been published in leading medical research journals. He has served on several editorial boards, including the Journal of Clinical Investigation and Diabetes. He is a member of numerous advisory panels for academia, government and industry. He is an elected member of the Association of American Physicians and the American Society for Clinical Investigation. His work is supported by the National Institutes of Health, the American Diabetes Association, the Russ Berrie Foundation, and the Brehm Coalition.
Publications - PubMed
1. L. Plum, H.V. Lin, R. Dutia, J. Tanaka, K.S. Aizawa, M. Matsumoto, A.J. Kim, N.X. Cawley, J-H. Paik, Y.P. Loh, R.A. DePinho, S.L. Wardlaw and D. Accili. (2009) The obesity susceptibility gene Carboxypeptidase E links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake. Nature Medicine 15:1195-1201
2. A.S. Banks, N. Kon, C. Knight, M. Matsumoto, R. Gutiérrez-Juárez, L. Rossetti, W. Gu and D. Accili. (2008) SirT1 gain-of-function increases energy efficiency and prevents diabetes in mice. Cell Metabolism 8:333-241
3. M. Matsumoto, A.Pocai, L. Rossetti, R.A. DePinho and D. Accili. (2007) Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver. Cell Metabolism 6:208-216
4. T. Kitamura, Y. Ido-Kitamura, Y. Funahashi, C.L. Shawber, D.H. Castrillon, R. Kollipara, R.A. DePinho, J. Kitajewski and D. Accili. (2007) A Foxo/Notch pathway controls myogenic differentiation and fiber type specification. Journal of Clinical Investigation 117:2477-2485
5. T. Kitamura, Y. Feng, Y. Ido-Kitamura, S.C. Chua, A.W. Xu, G.S. Barsh, L. Rossetti and D. Accili. (2006) Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake. Nature Medicine 12:534-540
6. M. Matsumoto, S. Han, T. Kitamura and D. Accili. (2006) Dual role of the transcription factor Foxo1 to regulate insulin sensitivity and lipid metabolism. Journal of Clinical Investigation 116:2464-2472