The Institute Of Human Nutrition

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PhD Dissertations

Congratulations to Ryo Higuchi-Sanabria, seen at right with PhD Program Director Debra Wolgemuth, PhD, who presented his thesis defense 'Regulation of mitochondrial quality control and its contribution to lifespan in S. cervisiae" on October 7, 2015.  

Mechanisms by which aldose reductase mediates cardiac ischemia-reperfusion injury by Mariane Abdillahi; Sponsor: Ravichandran Ramasamy, PhD

The role of LpL in the delivery of fatty acids to the heart by Ayanna Augustus; Sponsor: Ira Goldberg, MD

Functional analysis of cyclin A1 in hematopoiesis by Leah Batkiewicz; Sponsor: Debra Wolgemuth, PhD

Metabolic inflexibility in African American women by Evan Berk; Sponsor: F. Xavier Pi-Sunyer, MD, MPH

Effects of maternal insulin resistance on offspring metabolic and hypothalamic phenotypes by Jill Carmody; Sponsor: Rudolph Leibel, MD

Role of Hairless in epidermal proliferation by Alex Casta; Sponsor: Angela Christiano, PhD

Lipoprotein lipase in the arterial wall: regulation by dietary fatty acids by ChuChun Chang; Sponsor: Richard Deckelbaum, MD

The Regulators of Adipose Tissue Development and Lipolysis by Hye Rim Chang; Sponsor: Anthony W. Ferrante, Jr., PhD

The role of hypothalamic insulin and leptin signaling in regulating energy balance and stress by Chi Nok Chong; Sponsor: Lori M. Zeltser, PhD

Positional cloning of genes modifying susceptibility to type 2 diabetes in obese mice by Marija Chouinard; Sponsor: Rudolph Leibel, MD

The role of Blimp-1 in T-lymphocyte homeostasis and function by Luisa Cimmino; Sponsor: Kathryn Calame, PhD

Inhibition of VLDL assembly by apolipoprotein B antisense oligonucleotides stimulates autophagy of ER, preventing steatosis by Donna M. Conlon; Sponsor: Henry N. Ginsberg, MD

Contributions of activated hepatic stallate cells to hepatocarcinogenesis by Dianne Helerie Dapito; Sponsor. Robert Schwabe, PhD

Hypothalamic leptin signaling and energy homeostasis: A study in transgenic manipulation of murine models of obesity by Carl De Luca; Sponsor: Streamson Chua, MD, PhD

Physiology and pathophysiology of retinoid and lipid storage in hepatic stellate cell lipid droplets by Diana D’Ambrosio; Sponsor: William Blaner, PhD

Hypothalamic melanocortin regulation of energy balance and metabolism by Roxanne Dutia; Sponsor: Sharon Wardlaw, PhD

The tumor microenvironmental in gastric carcinogenesis: The players and their recruitment, modulators and side effects by Russell Ericksen; Sponsor: Timothy Wang, MD

Distinct roles of retinoid signaling in lower urinary tract by Devangini Gandhi; Sponsor: Cathy Mendelsohn, PhD

The consequences of neutral lipid deficiency in Saccharomyces cerevisiae by Jeanne Garbarino; Sponsor: Stephen Sturley, PhD

Smoking and high-fat diet: Risk factors regulating emphysema formation by Polina Golovatch; Sponsor: Jeanine D’Armiento, MD, PhD

Understanding the function and differentiation of adipose tissue macrophage by Ambar Grijalva; Sponsor. Anthony W. Ferrante, Jr., PhD

Characterizing energy-dependent transport of sterols across membranes by Sonia Gulati; Sponsor: Stephen Sturley, PhD

Models of nutrient-mediated effects on energy homeostasis in mice and humans by Solveig Halldorsdottir; Sponsor: Rudolph Leibel, MD

The role of Notch in neuroblastoma angiogenesis by Sonia Hernandez; Sponsor: Darrell Yamashiro, PhD

Lipoprotein lipase: Metabolic role in adipose tissue, arteries and muscle by Yaeko Hiyama; Sponsor: Ira Goldberg, MD

Regulation of mitochondrial quality control and its contribution to lifespan in S. cervisiae by Ryo Higuchi-Sanabria; Sponsor: Liza A. Pon, PhD

The interplay of free fatty acids and cholesterol through membranes and SREBP: A study of physical and cellular systems by Rebecca Juliano; Sponsor: Richard Deckelbaum, MD

Regulation of apolipoprotein B secretion by genetics, dietary n-3 fatty acids and a PPAR-gamma agonist by Chang Sook Kim; Sponsor: Li-Shin Huang, PhD

Studies examining the function of adipose tissue macrophages by Aliki Kosteli; Sponsor: Anthony W. Ferrante, PhD\Characterization of a murine atherosclerosis modifier locus by Chao-Ling Kuo; Sponsor: Alan Tall, MD

Transcriptional control of the gene for cyclin A1 and kinetic analysis of mutant cyclin A1/CDK complexes associated with infertility by Karen Lele; Sponsor: Debra Wolgemuth, PhD

The roles of protein kinase C beta and the novel gene HINT1 in breast cancer by Haiyang Li; Sponsor: I. Bernard Weinstein, MD, DSci (Hon)

 Human ARV1: A new modulator of lipid homeostasis by Ying Liu; Sponsor: Stephen Sturley, PhD

 Identification of genetic modifiers of diabetes by Na Luo; Sponsor: Streamson Chua, MD, PhD

Regulated expression of the interstitial collagenase matrix metalloproteinase-1 (MMP-1) in the lung by MAP kinase and Wnt signaling by Becky Mercer; Sponsor: Jeanine D’Armiento, MD, PhD

 Functional analysis of BARD1 mitotic phosphorylation by Ami Modi; Sponsor: Richard Baer, PhD

 Metabolic and pathological role of retinyl esters: The role of lecithin:retinol acyl transferase (LRAT) by Sheila O’Byrne; Sponsor: William Blaner, PhD

 Genetic studies of insulin resistance by Haruka Okamoto; Sponsor: Domenico Accili, MD

 Molecular basis for the functional consequences of the mouse mutation Mahoganoid (Mgrn1) by John Overton; Sponsor: Rudolph Leibel, MD

 Growing up POMC: Pro-opionmelanocortin in the developing brain by Stephanie Padilla; Sponsors: Lori Zeltser, PhD and Rudolph Leibel, MD

Structure/function analysis of the essential islet regulatory factor Nkx2.2 by James Papizan; Mentor: Lori Sussel, PhD

NTBI pathways in the kidney: NGAL scavenges iron to defend the urinary system from infection by Neal Paragas; Sponsor: Jonathan Barasch, PhD. * Awarded Dean’s prize for excellence in research

The positional cloning and physiological characterization of the mouse Mahoganoid (Mgm1(md)) mutation by Loan Phan; Sponsor: Rudy Leibel, MD

The Role of CtIP in BRCA1- mediated Tumor Suppression by Colleen Renee Reczek; Sponsor: Richard Baer; PhD

Cellular Fatty AcidToxicity: Extrapolating Yeast Screens into Mammalian Models by Kelly Ruggles; Sponsors: Stephen Sturley; PhD and Henry N. Ginsberg, MD

Survival and death mechanisms identified from gene expression analysis of a cellular model of Parkinson’s disease by Elizabeth Ryu; Sponsor: Lloyd Greene, PhD

Genetic analysis of murine atherosclerosis by Sara Seidelmann; Sponsor: Alan Tall, MD

Genetic analysis of in vivo function of mouse Brd2 and Brdt, two members of the Brd subfamily of bromodomain-containing genes by Enyuan Shang; Sponsor: Debra Wolgemuth, PhD

Ubiquitination regulates distinct cellular pathways in tumorigenesis by Jing Shan; Sponsor: Wei Gu, PhD

Characterization of ARV1-medicated endoplasmic reticulum to plasma membrane sterol transport in yeast and mammalian systems by Caryn Shechtman; Sponsor: Stephen Sturley, PhD

Keeping the fate: Fox2O, diabetes, and regenerative medicine by Chutima P. Talchai; Sponsor: Domenico Accili, MD

Fat in hearts: Uptake, storage, and turnover by Chad Michael Trent; Sponsor: Ira Goldberg

Understanding the neuro-molecular physiology of human obesity using iPSC-derived hypothalamic neurons by Liheng Wang; Sponsor. Rudolph L. Leibel, M.D.

Long-term gene therapy in a pre-clinical model of retinitis pigmentosa by Katherine Jean Wert; Sponsor: Stephen Tsang, MD, PhD

Omega 3 fatty acids are neuroprotective after cerebral hypoxia - ischemia in rodent models by Jill Johanna Williams; Sponsor: Richard J. Deckelbaum, MD

Novel insights into retinoid metabolism and actions: A genetic dissection by Nuttaporn Wongsririroj; Sponsor: William Blaner, PhD

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