Mark G. Frattini, M.D., Ph.D.

Mark G. Frattini, M.D., Ph.D.

New Patients Tel - 212 305-5098
New Patient Email -
Fax - 212-305-8111

Outpatient Office Location
Herbert Irving Pavilion, Garden
161 Fort Washington Ave at W. 165th St.
New York, NY

Physician Summary

Dr. Mark G. Frattini is an Associate Professor of Clinical Medicine and Director of Research for the Hematologic Malignancies Section in the Hematology/Oncology Division at the Columbia University Medical Center. Previously, Dr. Frattini was a member of the Leukemia Service and Experimental Therapeutics Center at Memorial Sloan-Kettering for almost 11 years. He is a medical oncologist who specializes in the treatment of adult patients with acute and chronic leukemias, myelodysplastic syndromes, and myeloproliferative disorders. Dr. Frattini’s laboratory research focuses on new drug development for acute and chronic leukemias with a special interest in small molecule inhibitors of cell cycle regulated kinases as therapeutic targets. He has discovered a small molecule inhibitor of the cdc7 kinase that is currently in clinical development with a plan for Phase I clinical studies for patients with relapsed and/or chemotherapy-refractory leukemia in 2013. In addition, Dr. Frattini’s research also involves the development of methods to more precisely determine patient-specific response to various chemotherapeutic agents with a plan to translate this technology into the clinical setting and provide a more personalized approach to therapy for patients with these malignant diseases. Dr. Frattini has lectured at national and international meetings and has published in various scientific journals, including Blood, Cell, EMBO, JNCCN, Journal of Biological Chemistry, Science, and Proceedings of the National Academy of Sciences USA. He received his M.D. and Ph.D. in Biochemistry and Molecular Biology from The University of Chicago and completed his fellowship training in Medical Oncology at The Johns Hopkins Hospital.

Clinical Expertise

  • Acute Myeloid Leukemia
  • Chronic Lymphocytic Leukemia
  • Acute Lymphoblastic Leukemia
  • Myelodysplastic Syndromes
  • Chronic Myelogenous Leukemia
  • Chronic Myelomonocytic Leukemia
  • Myeloproliferative Disease
  • Polycythemia Vera
  • Essential Thrombocythemia
  • Myelofibrosis
  • Leukemia
  • Hematologic Malignancy

Board Certifications

  • Internal Medicine
  • Medical Oncology


  • Associate Professor of Clinical Medicine, Columbia University Medical Center
  • Director of Research, Hematologic Malignancies Section, Division of Hematology/Oncology


  • M.D., 1997 The University of Chicago - Pritzker School of Medicine, Chicago, IL
  • Ph.D., 1994 Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL

Internship and Residency

  • 1997-1999, Osler Medical Service, Department of Medicine, The Johns Hopkins Hospital, Baltimore, MD


  • 1999-2002, Department of Oncology, The Johns Hopkins Hospital, Baltimore, MD