The Innovation in Biological and Medical Sciences Distinguished Lecture was established in 2013 to highlight and profile creative and exciting work from leaders in science. This new lectureship is part of the College of Physicians & Surgeons Dean's Lecture Series.
"Toward Precision Medicine in Neurodevelopmental Diseases"
David Goldstein, PhD
Director, Center for Human Genome Variation
The Richard and Pat Johnson Distinguished University Professor
Friday, May 16, 2014
Hammer Health Sciences Center
701 West 168th Street
Dr. Goldstein was trained in theoretical population genetics and has studied many aspects of human genetic variation over the past 20 years with a particular focus on the genetics of disease and treatment response. His early work focused primarily on genetic anthropology, while his more recent work has focused primarily on medical genetics and pharmacogenetics. Dr. Goldstein was professor of genetics at University College London from 1999 to 2005, when he moved to Duke University as a professor in the Departments of Molecular Genetics and Microbiology and Biology and became director of the Center for Human Genome Variation (CHGV.) In 2010 he was appointed the Richard and Pat Johnson Distinguished University Professor.
Under Dr. Goldstein's leadership, the CHGV has emerged as a leading human genetics research center with a number of seminal discoveries, including de novo mutations in ATP1A3, the gene responsible for alternating hemiplegia of childhood, and the role of IL28B in treatment response to hepatitis C infection. The center also has been a leader in the field of demonstrating the potential of next generation sequencing in diagnosing rare genetic and neurological conditions. Dr. Goldstein is a principal investigator of Epi4K, the NINDS epilepsy genetics center without walls, and he directs its genome sequencing and bioinformatic core. Epi4K is currently the largest epilepsy genetics project in the world and is in the process of generating whole exome and whole genome sequence data on no less than 4,000 patients with epilepsy.
Dr. Goldstein has authored more than 200 scholarly publications in the areas of population and medical genetics. He received the Royal Society/Wolfson research merit awards in the UK for work in human population genetics, the Triangle Business Journal Health Care Heroes Award: Innovator/Researcher Award (2008), and the University of North Carolina Clinical Services Award (2012). He chaired the Gordon Research Conference in Human Genetics & Genomics (2013) and currently serves on the NIH-NINDS Advisory Council. He was selected a fellow of AAAS in 2013.