Taub Institute: Genomics Core
AN NIA-FUNDED ALZHEIMER'S DISEASE RESEARCH CENTER

 

Columbia University
Medical Center
Neurological Institute

710 West 168th Street, 3rd floor
(212) 305-1818


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Patient Care

Memory Disorder Centers

Scott A. Small, M.DScott A. Small, M.D

Assistant Professor, Neurology

Phone:(212) 305-9194

Email: sas68@columbia.edu


Scott Small, MD is using a new functional magnetic resonance imaging (fMRI) analysis to identify which sub-regions of the hippocampus correlate with memory decline. His technique measures subtle changes in oxyhemoglobin levels, allowing him to see smaller structures in the brain. He has also used fMRI to examine multiple sites across the long axis of the hippocampal formation while subjects performed different phases of an associative memory task, learning to associate faces with names. The analysis revealed hippocampal circuit mechanisms that underlie memory encoding and retrieval.

Selected Recent Publications:

  • Small SA, Tsai WY, DeLaPaz R, Mayeux R, Stern Y. Imaging hippocampal function across the human life span: Is memory decline normal or not? Annals of Neurology. 51:290-295, 2002
  • Small SA. The longitudinal axis of the hippocampal formation: Its anatomy, circuitry and role in cognitive function. Review in the Neurosciences. 2002; 13: 183-194.
  • Small SA. Microscopic Measurements of Brain Metabolism with MRI; An effective approach for diagnosing Alzheimer's disease and mapping its course. Alzheimer's disease and Associated Disorders. 2003, in press.


 

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