Researchers at the Taub Institute are examining the role of heredity in Alzheimer's disease by identifying patients with a family history of memory problems. We are gathering detailed clinical information and blood samples to identify specific DNA markers that will help to assess risk for Alzheimer's disease.

In one of the most comprehensive genetic epidemiological studies of Alzheimer's disease ever attempted, Taub scientists are studying Hispanic families living in the Washington Heights area of Manhattan, as well as their close relatives in the Dominican Republic. We are also following a large number of African-American patients and their families, who are seen at our Harlem Hospital Satellite site as well as our main facilities.

Research Laboratory:

Our molecular genetics research laboratory has completed more than 4,000 APOE genotypes using both peripheral blood and autopsy tissue. In addition, they have generated several hundred lymphoblastoid lines from our patients. The Institute maintains a collection of DNA samples from Alzheimer's disease patients and controls, as well as from patients with other neurodegenerative diseases associated with aging. The DNA bank is a current and future resource for testing associations of genetic markers with susceptibility to Alzheimer's disease.

Recent Developments:

Current research indicates that known polymorphisms (or variations) nearby the APOE gene are associated with Alzheimer's disease. Studies are now underway to search for additional genes that increase susceptibility to Alzheimer's disease. Most recently, using this genetic resource, Taub investigators have identified a specific mutation in the presenilin-1 gene that appears to be a recurrent cause of early-to-mid-onset Alzheimer's disease uniquely in Hispanics.

To learn more about specific genetic research projects at the Taub Institute, please browse our faculty pages.