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Columbia University
Irving Medical Center
Neurological Institute

710 West 168th Street, 3rd floor
(212) 305-1818

Patient Care

Memory Disorder Centers

Lawrence S. Honig, M.D., Ph.D.

Professor, Clinical Neurology

Phone: (212) 305-9194
Fax: (212) 305-2526
Email: lh456@columbia.edu

Dr. Lawrence Honig's principal medical and scientific interests are in aging and neurodegenerative diseases of the brain. These latter include Alzheimer's disease, Lewy Body dementia, vascular cognitive impairment, and Creutzfeldt-Jakob disease, and also include the frontotemporal degeneration disease family including corticobasal degeneration, ALS-dementia, and progressive aphasia. His laboratory efforts are concentrated on molecular processes that occur in aging and degenerative brain diseases, including changes in chromosomal telomeres, and changes involved in protein processing and in the losses of nerve cells and their connections, the synapses. His research involves analysis of changes in human blood, fluid, and tissues, as well as the use of model systems including mice and cell culture. In addition to his laboratory investigations, he carries out clinical research on diagnosis, imaging, and drug treatment trials of patients with Alzheimer's disease and other degenerative brain conditions.

Selected Recent Publications:

• Lawrence S. Honig, M.-X. Tang, S. Albert, R. Costa, J. Luchsinger, J. J. Manly, Y. Stern, & R. Mayeux. Stroke and the Risk of Alzheimer's disease. 2003. Arch Neurol 60: 1707-1712.
• Lawrence S. Honig, Karen Bell, and Steven S. Chin. Frontotemporal Dementia. 2003. Science: Sci Aging Knowl Environ 2003(13): dn1 URL: http://sageke.sciencemag.org/cgi/content/full/sageke;2003/13/dn1
• Nikolaos Scarmeas and Lawrence S. Honig. Frontotemporal Degenerative Dementias. 2004. Clin Neurosci Res 3: 449-460.
• Lawrence S. Honig, Walter Kukull, Richard Mayeux. Atherosclerosis and AD: Analysis of Data from the US National Alzheimer's Coordinating Center. 2005. Neurology 64: 494-500.
• James McC. Noble, Peter Canoll, and Lawrence S. Honig. Brain tumor-associated dementia. 2005. Science: Sci Aging Knowl Environ 2005(34): dn2. URL: http://sageke.sciencemag.org/cgi/content/full/2005/34/dn2
• Jose A. Luchsinger, Christiane Reitz, Lawrence S. Honig, Ming-Xin Tang, Steven Shea, Richard Mayeux. Aggregation of Vascular Risk Factors and Risk of Incident Alzheimer's Disease. 2005. Neurology 65:545-551.
• Scott A. Small, Kelly Kent, Aimee Pierce, Conrad Leung, Min Suk Kang, Hirokazu Okada, Lawrence Honig, Jean-Paul Vonsattel, Tae-Wan Kim. Model-guided Microarray Implicates Retromer Complex in Alzheimer's Disease. 2005. Ann Neurol 58: 909-919.
• Clinton B. Wright, Jean Paul G. Vonsattel, Karen Bell, and Lawrence S. Honig. Dementia with Cerebrovascular Disease. 2006. Science: Sci Aging Knowl Environ 2006(10):dn1. URL: http://sageke.sciencemag.org/cgi/content/full/2006/10/dn1.
• Lawrence S. Honig, Nicole Schupf, Joseph H. Lee, Ming X. Tang, and Richard Mayeux. Short Telomere Length is Associated with Mortality and Dementia. 2006. Ann Neurol 60: 181-187.