The Tycko laboratory studies human genetics and epigenetics, with a current emphasis on cancer, Alzheimer's disease, and Down syndrome (trisomy 21).

Selected Recent Publications:

• Kerkel K, Spadola A, Yuan E, Kosek J, Jiang L, Hod E, Li K, Murty V, Schupf N, Vilain E, Morris M, Haghighi F, Tycko B (2008) Genomic surveys by methylation-sensitive SNP analysis identify sequence dependent allele-specific DNA methylation. Nature Genetics, in press.
  
  
• Li CM, Guo M, Salas M, Schupf N, Silverman W, Zigman WB, Husain S, Warburton D, Thaker H, Tycko B. (2006) Cell type-specific over-expression of chromosome 21 genes in fibroblasts and fetal hearts with trisomy 21. BMC Med Genet 7:24.
  
  
• Athan, E.S., Lee, J.H., Arriaga, A., Mayeux, R.P., and Tycko, B. (2002). "Polymorphisms in the promoter of the human APP gene: functional evaluation and allele frequencies in Alzheimer disease." Arch Neurol 59: 1793-9.
  
  
• Mayeux, R., Lee, J.H., Romas, S.N., Mayo, D., Santana, V., Williamson, J., Ciappa, A., Rondon, H.Z., Estevez, P., Lantigua, R., Medrano, M., Torres, M., Stern, Y., Tycko, B., and Knowles, J.A. (2002). "Chromosome-12 mapping of late-onset Alzheimer disease among Caribbean Hispanics." Am J Hum Genetics 70: 237-43.