Taub Institute: Genomics Core


Columbia University
Medical Center
Neurological Institute

710 West 168th Street, 3rd floor
(212) 305-1818

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About Us

Taub Faculty

Hongjun Fu, PhD

Hongjun Fu, PhD

Assistant Professor of Pathology and Cell Biology

Email: hf2296@cumc.columbia.edu

Tel: 201-446-3290

Research Summary:

Selective neuronal vulnerability in early Alzheimer’s disease and other tauopathies

One of the fundamental questions common to all of the neurodegenerative diseases is why a particular disease targets specific neuronal populations? In early Alzheimer's disease (AD), distinct subgroups of neurons in layer II of the entorhinal cortex (EC) and the CA1 region of the hippocampus are particularly vulnerable to degeneration, while other cortical and hippocampal cell populations do not show pathological signs at this disease stage. Dr. Fu’s research focuses on understanding which subtypes of neurons are vulnerable to tau pathology in early AD and other tauopathies as well as the molecular and cellular mechanisms underlying the selective neuronal vulnerability. In particular, He is interested in investigating the role of cell-autonomous (neurons) versus cell non-autonomous (microglia and/or astrocytes) effects as well as aging in selective vulnerability to proteinopathies in neurodegenerative diseases, specifically focusing on the ER proteostasis.

Education and Training:

PhD: Hong Kong University of Science and Technology (HKUST), Hong Kong, 2007

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