Director, Gertrude H. Sergievsky Center
Chair & Neurologist-in-Chief, Department of Neurology
Co-director, Taub Institute for Research on Alzheimer's Disease and the Aging Brain
Richard Mayeux is the Gertrude H. Sergievsky Professor of Neurology, Psychiatry, and Epidemiology at Columbia University. He is the director of the Gertrude H. Sergievsky Center and the co-director of the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Chairman Department of Neurology and Neurologist-in-Chief at New York Presbyterian Hospital. Born in New Orleans, Louisiana, he is a graduate of Oklahoma State University and the University of Oklahoma Health Sciences, School of Medicine. He also holds a masters degree in Epidemiology from Columbia University. He completed residencies in both Internal Medicine (Boston City Hospital, Boston University) and Neurology (Columbia Presbyterian Medical Center, Columbia College of Physicians and Surgeons). He also completed post-doctoral training fellowship in Behavioral Neurology at the Boston Veterans Administration Medical Center (at Boston University) with D. Frank Benson, funded by the National Institute of Health.
In 1992, Dr. Mayeux received the Leadership and Excellence in Alzheimer disease Award from the National Institute of Aging for his investigation of genetic and environmental interaction in the etiology and pathogenesis of Alzheimer disease and related forms of dementia. He has been elected to the Association of American Physicians, the American Epidemiological Society and The Institute of Medicine of the National Academies. He is also the 2007 recipient of the American Academy of Neurology's Potamkin Award for his research on Alzheimer's disease.
Since 1989, he has led a multidisciplinary, population-based, epidemiological investigation of Alzheimer disease and related conditions known as the Washington Heights-Inwood Community Aging Project. This body of work spanning a period of 18 years constitutes most of our current knowledge of the on the rates and risk factors for Alzheimer' disease among elderly from African-American and Caribbean Hispanic. This study has provided information on the relationship between Alzheimer disease and numerous risk factors; genotypic variability of apolipoprotein-e4 risk in different ethnic groups; and the relationship of alterations in lipid metabolism and risk of dementia.
He also directs a genetic linkage study of Alzheimer's disease in Caribbean Hispanic families. We have completed two full genome-wide scans in these families and are working to fine map regions of interest. We recently identified genetic variants in the sortilin-related receptor, SORL1 related to Alzheimer's disease.
Mayeux is the coordinating investigator for the National Institute on Aging - Late Onset Alzheimer's Disease Family Study. This study began in 2002 with the goal of identifying 1,000 families multiply affected by Alzheimer' disease.
Most recently, he is the lead investigator in a collaborative study of families that display exceptional survival and longevity.
Rippon GA, Tang MX, Lee JH, Lantigua R, Medrano M, Mayeux R. Familial Alzheimer disease in Latinos: interaction between APOE, stroke, and estrogen replacement. Neurology. 2006; 66:35-40.
Green NS, Mayeux R. The long and short of it: telomeres and the brain. Lancet Neurol 2006;5:999-1000.
Honig LS, Schupf N, Lee JH, Tang MX, Mayeux R. Shorter telomeres are associated with mortality in those with APOE-e4 and dementia. Ann Neurol 2006; 60:181-7.
Mayeux R. Genetic epidemiology of Alzheimer disease. Alzheimer Dis Assoc Disord. 2006; 20 (3 Suppl 2):S58-62.
Lee JH, Cheng R, Santana V, Williamson J, Lantigua R, Medrano M, Arriaga A, Stern Y, Tycko B, Rogaeva E, Wakutani Y, Kawarai T, St George-Hyslop P, Mayeux R. Expanded genome-wide scan implicates a novel locus at 3q28 among Caribbean Hispanics with familial Alzheimer disease. Arch Neurol 2006; 63:1591-8.
Luchsinger JA, Patel B, Tang MX, Schupf N, Mayeux R. Measures of adiposity and dementia risk in elderly persons. Arch Neurol 2007; 64:392-8.
Luchsinger JA, Tang MX, Miller J, Green R, Mayeux R. Relation of higher folate intake to lower risk of Alzheimer disease in the elderly. Arch Neurol 2007; 64:86-92.
Devanand DP, Pradhaban G, Liu X, Khandji A, De Santi S, Segal S, Rusinek H, Pelton GH, Honig LS, Mayeux R, Stern Y, Tabert MH, de Leon MJ. Hippocampal and entorhinal atrophy in mild cognitive impairment: prediction of Alzheimer disease. Neurology 2007; 68:828-36.
Luchsinger JA, Tang MX, Miller J, Green R, Mehta PD, Mayeux R. Relation of Plasma Homocysteine to Plasma Amyloid Beta Levels. Neurochem Res 2007; 32:775-781.
Rogaeva E, Meng Y, Lee JH, Gu Y, Kawarai T, Zou F, Katayama T, Baldwin CT, Cheng R, Hasegawa H, Chen F, Shibata N, Lunetta KL, Pardossi-Piquard R, Bohm C, Wakutani Y, Cupples LA, Cuenco KT, Green RC, Pinessi L, Rainero I, Sorbi S, Bruni A, Duara R, Friedland RP, Inzelberg R, Hampe W, Bujo H, Song YQ, Andersen OM, Willnow TE, Graff-Radford N, Petersen RC, Dickson D, Der SD, Fraser PE, Schmitt-Ulms G, Younkin S, Mayeux R, Farrer LA, St George-Hyslop P. The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease. Nat Genet 2007; 39:168-177.